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Relationship between serum matrix Metalloproteinase-9 levels and severity of multibacillary leprosy in patients aged 30 years and under

Proceedings Academic Universitas Jambi · Vol. 1 No. 2 (2025) · hlm. 1041–1049

DOI
10.22437/proca.v1i2.50520
Terbit
2025-11-30
Penerbit
LPPM Universitas Jambi
Bahasa
en
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Background: Leprosy presents a spectrum of immunological responses linked to pathological and clinical manifestations. Matrix Metalloproteinase-9 (MMP-9), an enzyme involved in extracellular matrix degradation and inflammation, has been implicated in cellular immunity. However, the relationship between MMP-9 levels and bacterial load in multibacillary (MB) leprosy remains incompletely understood, particularly across different age groups. Objective: To analyze the relationship between serum MMP-9 levels and Bacterial Index (BI) severity in MB leprosy patients, stratified by age groups. Methods: A cross-sectional comparative study was conducted from October 2017 to September 2018 at Dr. Rivai Abdullah Leprosy Hospital and Sukajadi Community Health Center, South Sumatra, Indonesia. Thirty-two newly diagnosed or recurrent MB leprosy patients were enrolled via consecutive sampling. Serum MMP-9 levels were measured using ELISA, and disease severity was classified by BI ( 0.05). Conclusion: Lower serum MMP-9 levels in severe MB leprosy may reflect diminished cell-mediated immunity. The significant inverse relationship between MMP-9 and BI in younger patients suggests age-dependent immunological variations. These findings support MMP-9 as a potential biomarker for disease severity assessment in MB leprosy.

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Erny KusdiyahAfiliasi tidak diketahui14
Armaidi DarmawanAfiliasi tidak diketahui10
Anggelia PuspasariAfiliasi tidak diketahui6
Rina Nofri EnisAfiliasi tidak diketahui6
Citra MaharaniAfiliasi tidak diketahui5
Amelia Dwi FitriAfiliasi tidak diketahui5
Huntari HarahapAfiliasi tidak diketahui5
Ahmad SyauqyAfiliasi tidak diketahui4
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Andika SulistiawanAfiliasi tidak diketahui4
Nyimas Natasha Ayu ShafiraAfiliasi tidak diketahui4
Afifah AmatullahAfiliasi tidak diketahui3
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HafizahAfiliasi tidak diketahui3
Mirna Marhami IskandarAfiliasi tidak diketahui3
FairuzAfiliasi tidak diketahui3
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Annissa DelfiraAfiliasi tidak diketahui2
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Rita HalimUniversitas Jambi2
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Herlambang HerlambangUniversitas Jambi2
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Sumber metadata: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/PROCA/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Relationship between serum matrix Metalloproteinase-9 levels and severity of multibacillary leprosy in patients aged 30 years and under</dc:title>
	<dc:creator xml:lang="en">Fitriyanti</dc:creator>
	<dc:creator xml:lang="en">Perkasa, Tengku Arief Buana</dc:creator>
	<dc:creator xml:lang="en">Aurora, Wahyu Indah Dewi</dc:creator>
	<dc:creator xml:lang="en">Nastiti, Niken Irfa</dc:creator>
	<dc:creator xml:lang="en">Ekaputri, Tia Wida</dc:creator>
	<dc:creator xml:lang="en">Pratiwi, Rini</dc:creator>
	<dc:creator xml:lang="en">Istarini, Attiya</dc:creator>
	<dc:subject xml:lang="en">Leprosy, multibacillary; matrix metalloproteinase 9; bacterial load; cell-mediated immunity; biomarkers; age factors</dc:subject>
	<dc:description xml:lang="en">Background: Leprosy presents a spectrum of immunological responses linked to pathological and clinical manifestations. Matrix Metalloproteinase-9 (MMP-9), an enzyme involved in extracellular matrix degradation and inflammation, has been implicated in cellular immunity. However, the relationship between MMP-9 levels and bacterial load in multibacillary (MB) leprosy remains incompletely understood, particularly across different age groups. Objective: To analyze the relationship between serum MMP-9 levels and Bacterial Index (BI) severity in MB leprosy patients, stratified by age groups. Methods: A cross-sectional comparative study was conducted from October 2017 to September 2018 at Dr. Rivai Abdullah Leprosy Hospital and Sukajadi Community Health Center, South Sumatra, Indonesia. Thirty-two newly diagnosed or recurrent MB leprosy patients were enrolled via consecutive sampling. Serum MMP-9 levels were measured using ELISA, and disease severity was classified by BI (&amp;lt;3 vs ≥3) using Slit Skin Smear. Data were analyzed using unpaired t-tests and Kruskal-Wallis tests, with significance set at P&amp;lt;0.05. Results: Age group and marital status significantly influenced BI severity (P&amp;lt;0.05). Among patients aged &amp;lt;30 years, those with BI≥3 had significantly lower serum MMP-9 levels (2101.44±430.02 ng/L) compared to BI&amp;lt;3 (2621.57±469.37 ng/L; P=0.044). In patients aged ≥30 years, MMP-9 levels were lower in BI≥3 group (1770.19±477.21 ng/L vs 2068.67±550.58 ng/L), but this difference was not statistically significant (P&amp;gt;0.05). Conclusion: Lower serum MMP-9 levels in severe MB leprosy may reflect diminished cell-mediated immunity. The significant inverse relationship between MMP-9 and BI in younger patients suggests age-dependent immunological variations. These findings support MMP-9 as a potential biomarker for disease severity assessment in MB leprosy.</dc:description>
	<dc:publisher xml:lang="en">LPPM Universitas Jambi</dc:publisher>
	<dc:date>2025-11-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/PROCA/article/view/50520</dc:identifier>
	<dc:identifier>10.22437/proca.v1i2.50520</dc:identifier>
	<dc:source xml:lang="en">Proceedings Academic Universitas Jambi; Vol. 1 No. 2 (2025): The 6th Jambi Medicine and Health Science International Conference (JAMHESIC); 1041-1049</dc:source>
	<dc:source>10.22437/proca.v1i2</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/PROCA/article/view/50520/22730</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Fitriyanti, Tengku Arief Buana Perkasa, Wahyu Indah Dewi Aurora, Annissa Delfira, Zahra Frizki Asty, Niken Irfa Nastiti, Tia Wida Ekaputri, Attiya Istarini</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>