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Effects of Young Areca Nut (Areca catechu L.) Administration on the Splenic Histopathological Features of Adult Sprague–Dawley Rats (Rattus norvegicus)

Scientific Of Environmental Health and Diseases · Vol. 1 No. 1 (2021) · hlm. 35–43

DOI
10.22437/esehad.v1i1.10764
ISSN
2774-4337
Terbit
2021-06-17
Penerbit
LPPM Universitas Jambi
Bahasa
en

Abstrak

ABSTRACT Background: Areca’s seed is an herbal beverage that are widely consumed as a betel nut. Areca’s seed contains arecoline. High doses of arecoline can damage many organ include spleen. There has been no further histopathological research of the effects with lower doses of betel nut on spleen.Methods: Ten rats Sprague Dawley strain white rats, aged 2-3 months, with 150-200 of grams were divided into 2 groups, namely the control group given aquades and the treatment group given areca nut dose of 50mg/kgBB for 28 days by feeding tube. Histopathologi’s indicators with hematoxilin eosin staining were analyzed by light microscope with 40X for diameter white pulp, 100X for congestion, and 400X for hematopoiesis extrmedullery and necrosis. The assessment for hematopoiesis extramedullery and necrosis used 5 high power-field, congestion used 3 high power field, and changes of diameter whites pulp used 10 high power-field. The data were analyzed by T- Independent statistical test.Results: Average congestion and hematopoiesis extramedullery of treatment group greater than control with p value 0,05).Conclusion: Areca’ seed doses 50 mg/KgWB that given for 28 days showed congestion and extra medullary hematopoiesis on rat’s spleen tissue.

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  • Universitas Jambi
  • Gunma University
  • Padjadjaran University
  • Diponegoro University
  • Universitas Pembangunan Nasional Veteran Jakarta
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  • Organisasi berbeda
  • Organisasi sama
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Rekan penulisOrganisasiArtikel bersama
Erny KusdiyahAfiliasi tidak diketahui3
Amelia Dwi FitriAfiliasi tidak diketahui3
Anggelia PuspasariAfiliasi tidak diketahui3
Amelia Dwi FitriUniversitas Jambi3
Anggelia PuspasariUniversitas Jambi3
Susan TarawifaUniversitas Jambi3
Rina Nofri EnisUniversitas Jambi3
Wahyu Indah Dewi AuroraAfiliasi tidak diketahui2
Erny KusdiyahUniversitas Jambi2
Nyimas Natasha Ayu ShafiraUniversitas Jambi2
Anati PurwakanthiUniversitas Jambi2
Nyimas Natasha Ayu ShafiraAfiliasi tidak diketahui2
Asro Hayani HarahapAfiliasi tidak diketahui2
Putri Sari WulandariUniversitas Jambi2
Mirna Marhami IskandarUniversitas Jambi2
Wahyu Indah Dewi AuroraUniversitas Jambi2
Budi HandonoPadjadjaran University1
Leri S. FariedGunma University1
Ahmad FarriedGunma University1
Hiroyuki KuwantoGunma University1
Firman Fuad WirakusumahPadjadjaran University1
Asrial AsrialUniversitas Jambi1
Muhammad Salsabeela RusdiUniversitas Jambi1
Titik HindriatiUniversitas Jambi1
Andi SubandiAfiliasi tidak diketahui1
Asro Hayani HarahapAfiliasi tidak diketahui1
Jelica OctavianiUniversitas Jambi1
Esa Indah Ayudia TanAfiliasi tidak diketahui1
Patrick William GadingUniversitas Jambi1
Ahmad SyauqyDiponegoro University1
Miftahurrahma MiftahurrahmaUniversitas Jambi1
Ima MariaUniversitas Pembangunan Nasional Veteran Jakarta1
Raihanah SuzanUniversitas Jambi1
Humaryanto HumaryantoUniversitas Jambi1
Nuri Putri HarissaUniversitas Jambi1
Putri AkbiditaUniversitas Jambi1

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Sumber metadata: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/e-sehad/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Effects of Young Areca Nut (Areca catechu L.) Administration on the Splenic Histopathological Features of Adult Sprague–Dawley Rats (Rattus norvegicus)</dc:title>
	<dc:creator xml:lang="en">Adrian, Adek</dc:creator>
	<dc:creator xml:lang="en">Rahman, Ave Olivia</dc:creator>
	<dc:creator xml:lang="en">Herlambang, Herlambang</dc:creator>
	<dc:creator xml:lang="en">Dewi, Hasna</dc:creator>
	<dc:subject xml:lang="en">Areca catechu L</dc:subject>
	<dc:subject xml:lang="en">Betel nut</dc:subject>
	<dc:subject xml:lang="en">Toxicity</dc:subject>
	<dc:subject xml:lang="en">hematopoiesis extramedullery</dc:subject>
	<dc:description xml:lang="en">ABSTRACT
Background: Areca’s seed is an herbal beverage that are widely consumed as a betel nut. Areca’s seed contains arecoline. High doses of arecoline can damage many organ include spleen. There has been no further histopathological research of the effects with lower doses of betel nut on spleen.Methods: Ten rats Sprague Dawley strain white rats, aged 2-3 months, with 150-200 of grams were divided into 2 groups, namely the control group given aquades and the treatment group given areca nut dose of 50mg/kgBB for 28 days by feeding tube. Histopathologi’s indicators with hematoxilin eosin staining were analyzed by light microscope with 40X for diameter white pulp, 100X for congestion, and 400X for hematopoiesis extrmedullery and necrosis. The assessment for hematopoiesis extramedullery and necrosis used 5 high power-field, congestion used 3 high power field, and changes of diameter whites pulp used 10 high power-field. The data were analyzed by T- Independent statistical test.Results: Average congestion and hematopoiesis extramedullery of treatment group greater than control with p value &amp;lt;0,05. Average necrosis and changes of diameter white pulp of treatment group greater than control group, but there is no significant difference statistically (p value &amp;gt;0,05).Conclusion: Areca’ seed doses 50 mg/KgWB that given for 28 days showed congestion and extra medullary hematopoiesis on rat’s spleen tissue.</dc:description>
	<dc:publisher xml:lang="en">LPPM Universitas Jambi</dc:publisher>
	<dc:date>2021-06-17</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/e-sehad/article/view/10764</dc:identifier>
	<dc:identifier>10.22437/esehad.v1i1.10764</dc:identifier>
	<dc:source xml:lang="en">Scientific Of Environmental Health and Diseases; Vol. 1 No. 1 (2021): Scientific of Envitonmental Health And Diseases; 35-43</dc:source>
	<dc:source>2774-4337</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/e-sehad/article/view/10764/25304</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2020 Electronic Journal  Scientific of Environmental Health And Disease</dc:rights>
</oai_dc:dc>