Factors Associated with Mortality Among Patients with Drug-Resistant Pulmonary Tuberculosis in Sumatera, Indonesia, 2020–2024

Wahyuni, Fajriani Dwi; Widoyo, Ratno; Syafrawati, Syafrawati

doi:10.22437/jkmj.v10i1.55369

Akses terbuka Jurnal

Factors Associated with Mortality Among Patients with Drug-Resistant Pulmonary Tuberculosis in Sumatera, Indonesia, 2020–2024

Jurnal Kesmas Jambi · Vol. 10 No. 1 (2026) · hlm. 147–158

DOI: 10.22437/jkmj.v10i1.55369
ISSN: 2580-5894, 2549-8053
Terbit: 2026-03-31
Penerbit: Program Studi Ilmu Kesehatan Masyarakat, Universitas Jambi
Bahasa: en
Lisensi: creativecommons.org/licenses/by/4.0

Abstrak

Drug-resistant tuberculosis (DR-TB) remains a major public health problem due to its high mortality and low treatment success rates. Sumatra is one of the regions in Indonesia with a high burden of DR-TB mortality. This study aimed to analyze factors associated with mortality among patients with drug-resistant pulmonary tuberculosis in Sumatra during 2020–2024. This study used a quantitative analytical observational design with a retrospective cohort approach utilizing secondary data from the Tuberculosis Information System (SITB) of the Ministry of Health of Indonesia. A total sampling technique was applied to all eligible DR-TB patients. The dependent variable was mortality during treatment, while independent variables included age, sex, employment status, HIV status, type of health facility, residential area, and treatment history. Data were analyzed using univariate, bivariable, and multivariable analyses. Multivariable analysis was performed to identify factors associated with mortality after adjustment for confounding factors. The results showed that age and treatment history were significantly associated with mortality (p<0.05). Patients aged ≥45 years had a 1.60 times higher risk of death compared to younger patients, while previously treated patients had a 1.32 times higher risk of mortality compared to new cases. Other variables were not significantly associated with mortality. These findings highlight the importance of closer monitoring among older and previously treated DR-TB patients.

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Andalas University

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Rekan penulis	Organisasi	Artikel bersama
Defriman Djafri	Andalas University	3
Dien Gusta Anggraini Nursal	Andalas University	2
Yunita Diastanti	Andalas University	1
Masrizal Masrizal	Andalas University	1
Yeffi Masnarivan	Andalas University	1
Pujatul Hasanah	Andalas University	1
Vivi Triana	Andalas University	1
Anisa Salsabila	Andalas University	1
Aulia Putri	Andalas University	1
Azzahra Iwan Gusmana	Andalas University	1
Dwilly Novia	Andalas University	1

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Sumber metadata: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/jkmj/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.

Metadata asli (oai_dc)

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	<dc:title xml:lang="en">Factors Associated with Mortality Among Patients with Drug-Resistant Pulmonary Tuberculosis in Sumatera, Indonesia, 2020–2024</dc:title>
	<dc:creator xml:lang="en">Wahyuni, Fajriani Dwi</dc:creator>
	<dc:creator xml:lang="en">Widoyo, Ratno</dc:creator>
	<dc:creator xml:lang="en">Syafrawati, Syafrawati</dc:creator>
	<dc:subject xml:lang="en">Drug-resistant tuberculosis</dc:subject>
	<dc:subject xml:lang="en">Mortality</dc:subject>
	<dc:subject xml:lang="en">Risk factors</dc:subject>
	<dc:subject xml:lang="en">Retrospective cohort</dc:subject>
	<dc:subject xml:lang="en">Indonesia</dc:subject>
	<dc:description xml:lang="en">Drug-resistant tuberculosis (DR-TB) remains a major public health problem due to its high mortality and low treatment success rates. Sumatra is one of the regions in Indonesia with a high burden of DR-TB mortality. This study aimed to analyze factors associated with mortality among patients with drug-resistant pulmonary tuberculosis in Sumatra during 2020–2024. This study used a quantitative analytical observational design with a retrospective cohort approach utilizing secondary data from the Tuberculosis Information System (SITB) of the Ministry of Health of Indonesia. A total sampling technique was applied to all eligible DR-TB patients. The dependent variable was mortality during treatment, while independent variables included age, sex, employment status, HIV status, type of health facility, residential area, and treatment history. Data were analyzed using univariate, bivariable, and multivariable analyses. Multivariable analysis was performed to identify factors associated with mortality after adjustment for confounding factors. The results showed that age and treatment history were significantly associated with mortality (p&amp;lt;0.05). Patients aged ≥45 years had a 1.60 times higher risk of death compared to younger patients, while previously treated patients had a 1.32 times higher risk of mortality compared to new cases. Other variables were not significantly associated with mortality. These findings highlight the importance of closer monitoring among older and previously treated DR-TB patients.</dc:description>
	<dc:publisher xml:lang="en">Program Studi Ilmu Kesehatan Masyarakat, Universitas Jambi</dc:publisher>
	<dc:date>2026-03-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/jkmj/article/view/55369</dc:identifier>
	<dc:identifier>10.22437/jkmj.v10i1.55369</dc:identifier>
	<dc:source xml:lang="en">Jurnal Kesmas Jambi; Vol. 10 No. 1 (2026): VOLUME 10 - NUMBER 1 (DECEMBER 2025 - MARCH 2026); 147-158</dc:source>
	<dc:source>2580-5894</dc:source>
	<dc:source>2549-8053</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/jkmj/article/view/55369/24741</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Fajriani Dwi Wahyuni, Ratno Widoyo, Syafrawati Syafrawati (Author)</dc:rights>
	<dc:rights xml:lang="en">http://creativecommons.org/licenses/by/4.0</dc:rights>
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