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The Effect of Ethanol Extract of Senggani Leaves (Melastoma malabathricum) on Reducing Paw Edema in Rats Induced By Carrageenan

Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan · Vol. 13 No. 1 (2025) · hlm. 103–109

DOI
10.22437/jmj.v13i1.38925
ISSN
2580-6874, 2339-269X
Terbit
2025-06-01
Penerbit
FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI
Bahasa
en

Abstrak

Background: The extract of senggani leaves (Melastoma malabathricum) has attracted attention as a potential anti-inflammatory agent due to its diverse phytochemical content, including flavonoids, tannins, and other polyphenols, which have been shown to possess antioxidant and anti-inflammatory activities in several previous studies. This study aims to determine the difference in the percentage of inflammation inhibition of paw edema in rats induced by carrageenan through the administration of senggani leaves extract. Methods: In this study, 24 rats were divided into 4 groups. Negative control group was given Na-CMC 0.5%, Positive control group was given Na-diclofenac 50 mg/kg BW. Two dosage groups were given senggani extract solution at 250 and 500 mg/kg BW. Carrageenan is used to induce local inflammation by injecting a 2% carrageenan solution in physiological NaCl subcutaneously into the subplantar region of all test animal groups to elicit an edema response. Paw thickness is measured using calipers at hour 0 before inflammation induction, followed by measurements at hours 1, 2, 3, 4, and 5. Results: The peak inhibitory effect (62.10% and 60.41%) for both doses of senggani extract was observed at the 3rd hour, suggesting a rapid onset of action. At the higher dose (500 mg/kg BW), senggani extract exhibited comparable or even slightly superior inhibitory effects to Na-diclofenac. Conclusion: Senggani extract has potential as a natural anti-edema agent. Further research is needed to explore its mechanism of action and optimize its therapeutic use.

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Rekan penulisOrganisasiArtikel bersama
Susan TarawifaUniversitas Jambi11
Nyimas Natasha Ayu ShafiraUniversitas Jambi10
Anggelia PuspasariUniversitas Jambi9
Erny KusdiyahUniversitas Jambi6
Huntari HarahapUniversitas Jambi4
Citra MaharaniAfiliasi tidak diketahui4
Citra MaharaniUniversitas Jambi4
Wahyu Indah Dewi AuroraUniversitas Jambi4
Esa Indah AyudiaUniversitas Jambi3
Herlambang HerlambangUniversitas Jambi3
Rita HalimUniversitas Jambi3
Hanina HaninaUniversitas Jambi3
Lipinwati LipinwatiUniversitas Jambi3
Attiya IstariniUniversitas Jambi3
Herlambang HerlambangUniversitas Jambi2
Amelia Dwi FitriUniversitas Jambi2
Tia Wida Ekaputri HzUniversitas Jambi2
Tengku Arief Buana PerkasaUniversitas Jambi2
Sri Astuti SiregarUniversitas Jambi1
Puspita SariUniversitas Jambi1
Adek AdrianUniversitas Jambi1
Ave Olivia RahmanUniversitas Jambi1
amadea rizkiyani noorAfiliasi tidak diketahui1
NuriyahAfiliasi tidak diketahui1
Mhd Habib Dwi MahendraAfiliasi tidak diketahui1
HaninaAfiliasi tidak diketahui1
Zahra Frizki AstyUniversitas Jambi1
Intan OktariAfiliasi tidak diketahui1
Ismi Nurwaqiah IbnuUniversitas Jambi1
Hendra Dhermawan SitanggangUniversitas Jambi1
Hanina HaninaAfiliasi tidak diketahui1
Tia Wida Ekaputri HzAfiliasi tidak diketahui1
Muhammad FadliAfiliasi tidak diketahui1
Rita HalimUniversitas Jambi1
Dhea AssyifaAfiliasi tidak diketahui1
Tia Wida Ekaputri HzAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/kedokteran/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">The Effect of Ethanol Extract of Senggani Leaves (Melastoma malabathricum) on Reducing Paw Edema in Rats Induced By Carrageenan</dc:title>
	<dc:creator xml:lang="en">Ekaputri, Tia Wida</dc:creator>
	<dc:creator xml:lang="en">Dewi, Hasna</dc:creator>
	<dc:creator xml:lang="en">Wulandari, Putri Sari</dc:creator>
	<dc:creator xml:lang="en">Enis, Rina Nofri</dc:creator>
	<dc:subject xml:lang="en">Senggani Leaves</dc:subject>
	<dc:subject xml:lang="en">Melastoma Malabathricum</dc:subject>
	<dc:subject xml:lang="en">Edema</dc:subject>
	<dc:subject xml:lang="en">Local inflammation</dc:subject>
	<dc:subject xml:lang="en">carrageenan</dc:subject>
	<dc:description xml:lang="en">Background: The extract of senggani leaves (Melastoma malabathricum) has attracted attention as a potential anti-inflammatory agent due to its diverse phytochemical content, including flavonoids, tannins, and other polyphenols, which have been shown to possess antioxidant and anti-inflammatory activities in several previous studies. This study aims to determine the difference in the percentage of inflammation inhibition of paw edema in rats induced by carrageenan through the administration of senggani leaves extract.
Methods: In this study, 24 rats were divided into 4 groups. Negative control group was given Na-CMC 0.5%, Positive control group was given Na-diclofenac 50 mg/kg BW. Two dosage groups were given senggani extract solution at 250 and 500 mg/kg BW. Carrageenan is used to induce local inflammation by injecting a 2% carrageenan solution in physiological NaCl subcutaneously into the subplantar region of all test animal groups to elicit an edema response. Paw thickness is measured using calipers at hour 0 before inflammation induction, followed by measurements at hours 1, 2, 3, 4, and 5.
Results: The peak inhibitory effect (62.10% and 60.41%) for both doses of senggani extract was observed at the 3rd hour, suggesting a rapid onset of action. At the higher dose (500 mg/kg BW), senggani extract exhibited comparable or even slightly superior inhibitory effects to Na-diclofenac.
Conclusion: Senggani extract has potential as a natural anti-edema agent. Further research is needed to explore its mechanism of action and optimize its therapeutic use.</dc:description>
	<dc:publisher xml:lang="en">FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI</dc:publisher>
	<dc:date>2025-06-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/kedokteran/article/view/38925</dc:identifier>
	<dc:identifier>10.22437/jmj.v13i1.38925</dc:identifier>
	<dc:source xml:lang="en">Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan; Vol. 13 No. 1 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan; 103-109</dc:source>
	<dc:source>2580-6874</dc:source>
	<dc:source>2339-269X</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/kedokteran/article/view/38925/20993</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan</dc:rights>
</oai_dc:dc>