Melola Discovery

← Melola Discovery

Jurnal

The Genetic Variation of Ace Gene Rs4343 Has Lack Association With Pre-Eclampsia: Case-Control Study In Jambi Malay Population

Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan · Vol. 13 No. 1 (2025) · hlm. 60–66

DOI
10.22437/jmj.v13i1.41334
ISSN
2580-6874, 2339-269X
Terbit
2025-05-24
Penerbit
FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI
Bahasa
en

Abstrak

Background: The PE is leading cause of maternal and neonatal mortality and morbidity worldwide. The etiology of PE remains not yet clearly identified, genetics contributed 20-40% of PE. The variation of the rs4343 gene was significant as a risk factor for PE and the severity of PE with effect sizes varying between studies. To the best of our knowledge, the association of rs4343 in the ACE gene for PE risk has not been reported to the population of Indonesia, especially the Jambi Malays. Aims: This study aims to reveal the association of Genetic Variation of ACE gene rs4343 with preeclampsia. Methods: This recent study was case-control, 78 pregnant women matching based on age and pregnancy number participated in this study. The preeclampsia diagnosis is based on the criteria of the American College of Obstetricians and Gynecologists. The genotyping method was tetra ARMS-PCR. Bivariate statistical analysis was performed. Results: The proportion of the AA genotype and AG genotype was slightly different between the two groups, but all GG genotypes suffered preeclampsia. The recessive model reported the GG/AG genotype has a higher risk of PE than the AA genotype (p-value 0.784; OR 1.16, 95% CI (0.40-3.41)). The allele model reported that the G allele (p-value 0.338; OR 1.59, 95% CI (0.62-4.14)) had a higher risk than the A allele. However, all those differences do not reach statistically significant. Conclusion: Genetic Variation of ACE gene rs4343 Has Lack Association with Pre-eclampsia.

Kata kunci

Jaringan kolaborasi para penulis

40 penulis · 166 tautan kepenulisan bersama · 11 lintas organisasi · menampilkan 40 yang paling banyak terhubung

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • Universitas Jambi
  • Gunma University
  • Padjadjaran University
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Nyimas Natasha Ayu ShafiraUniversitas Jambi29
Amelia Dwi FitriUniversitas Jambi12
Erny KusdiyahUniversitas Jambi10
Tia Wida EkaputriUniversitas Jambi9
Citra MaharaniAfiliasi tidak diketahui8
Wahyu Indah Dewi AuroraUniversitas Jambi7
Rita HalimUniversitas Jambi7
Tia Wida Ekaputri HzUniversitas Jambi7
Herlambang HerlambangUniversitas Jambi6
Huntari HarahapUniversitas Jambi5
Esa Indah AyudiaUniversitas Jambi4
Erny KusdiyahAfiliasi tidak diketahui3
Amelia Dwi FitriAfiliasi tidak diketahui3
Anggelia PuspasariAfiliasi tidak diketahui3
Arnild Augina MekarisceUniversitas Jambi2
Wahyu Indah Dewi AuroraAfiliasi tidak diketahui2
Nyimas Natasha Ayu ShafiraAfiliasi tidak diketahui2
Asro Hayani HarahapAfiliasi tidak diketahui2
Hasna DewiUniversitas Jambi2
Budi HandonoPadjadjaran University1
Leri S. FariedGunma University1
Ahmad FarriedGunma University1
Hiroyuki KuwantoGunma University1
Firman Fuad WirakusumahPadjadjaran University1
Asrial AsrialUniversitas Jambi1
Muhammad Salsabeela RusdiUniversitas Jambi1
Titik HindriatiUniversitas Jambi1
Charles Apul SimanjuntakUniversitas Jambi1
Nys. Natasha Ayu SUniversitas Jambi1
Vinna Rahayu NingsihUniversitas Jambi1
Sri Astuti SiregarUniversitas Jambi1
Puspita SariUniversitas Jambi1
Marta Butar ButarUniversitas Jambi1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/kedokteran/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">The Genetic Variation of Ace Gene Rs4343 Has Lack Association With Pre-Eclampsia: Case-Control Study In Jambi Malay Population</dc:title>
	<dc:creator xml:lang="en">Puspasari, Anggelia</dc:creator>
	<dc:creator xml:lang="en">Herlambang, Herlambang</dc:creator>
	<dc:creator xml:lang="en">Maharani, Citra</dc:creator>
	<dc:creator xml:lang="en">Perkasa, Tengku Arief Buana</dc:creator>
	<dc:creator xml:lang="en">Enis, Rina Nofri</dc:creator>
	<dc:creator xml:lang="en">Tarawifa, Susan </dc:creator>
	<dc:creator xml:lang="en">Syukur, Astian Nathaniel</dc:creator>
	<dc:subject xml:lang="en">Preeclampsia</dc:subject>
	<dc:subject xml:lang="en">ACE</dc:subject>
	<dc:subject xml:lang="en">Malay</dc:subject>
	<dc:subject xml:lang="en">rs4343</dc:subject>
	<dc:subject xml:lang="en">Indonesia</dc:subject>
	<dc:description xml:lang="en">Background: The PE is leading cause of maternal and neonatal mortality and morbidity worldwide. The etiology of PE remains not yet clearly identified, genetics contributed 20-40% of PE. The variation of the rs4343 gene was significant as a risk factor for PE and the severity of PE with effect sizes varying between studies. To the best of our knowledge, the association of rs4343 in the ACE gene for PE risk has not been reported to the population of Indonesia, especially the Jambi Malays. Aims: This study aims to reveal the association of Genetic Variation of ACE gene rs4343 with preeclampsia.
Methods: This recent study was case-control, 78 pregnant women matching based on age and pregnancy number participated in this study. The preeclampsia diagnosis is based on the criteria of the American College of Obstetricians and Gynecologists. The genotyping method was tetra ARMS-PCR. Bivariate statistical analysis was performed.
Results: The proportion of the AA genotype and AG genotype was slightly different between the two groups, but all GG genotypes suffered preeclampsia. The recessive model reported the GG/AG genotype has a higher risk of PE than the AA genotype (p-value 0.784; OR 1.16, 95% CI (0.40-3.41)). The allele model reported that the G allele (p-value 0.338; OR 1.59, 95% CI (0.62-4.14)) had a higher risk than the A allele. However, all those differences do not reach statistically significant.
Conclusion: Genetic Variation of ACE gene rs4343 Has Lack Association with Pre-eclampsia.</dc:description>
	<dc:publisher xml:lang="en">FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI</dc:publisher>
	<dc:date>2025-05-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/kedokteran/article/view/41334</dc:identifier>
	<dc:identifier>10.22437/jmj.v13i1.41334</dc:identifier>
	<dc:source xml:lang="en">Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan; Vol. 13 No. 1 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan; 60-66</dc:source>
	<dc:source>2580-6874</dc:source>
	<dc:source>2339-269X</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/kedokteran/article/view/41334/20987</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan</dc:rights>
</oai_dc:dc>