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Exploration The Multifaceted Role Of Vitamins In Epigenetic Regulation: Insights Into DNA Methylation And Histone Modification

Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan · Vol. 13 No. 1 (2025) · hlm. 76–90

DOI
10.22437/jmj.v13i1.42536
ISSN
2580-6874, 2339-269X
Terbit
2025-05-28
Penerbit
FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI
Bahasa
en

Abstrak

Background: Recent research shows that vitamins actively regulate epigenetic mechanisms like DNA methylation and histone changes. Gene regulation, cellular differentiation, and disease development depend on these pathways. Aims: This review aims to synthesize current evidence on how vitamins A, B, C, D, E, and K influence epigenetic regulation, and to elucidate their potential roles in health maintenance and disease prevention. Methods: NCBI and ScienceDirect were used to search English-language literature from 2015 to 2024 for a narrative review. To capture vitamins' direct and indirect impacts on epigenetic pathways, selected peer-reviewed papers were qualitatively examined. Results: Vitamin A affects gene expression via receptor-mediated mechanisms which modify chromatin structure. B vitamins provide methyl donors for DNA methylation and histone changes. Vitamin C cofactors TET enzymes and histone demethylases, supporting active DNA demethylation and histone acetylation. The vitamin D receptor (VDR) affects DNA methyltransferases and histone-modifying enzymes, regulating gene transcription. Vitamins E and K modulate oxidative stress and histone changes to stabilize the epigenome, which may benefit cancer treatment and metabolic regulation. Conclusion: Vitamins' diverse and linked epigenetic regulatory activities are highlighted. These micronutrients may help prevent and treat cancer, metabolic problems, and developmental anomalies by maintaining genomic integrity and influencing gene expression. Keywords: Vitamins, Epigenetics, DNA Methylation, Histone Modification, Nutritional Epigenetics, Gene Expression.

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  • Universitas Jambi
  • Sultan Ageng Tirtayasa University
  • Duta Wacana Christian University
  • Afiliasi tidak diketahui
  • Organisasi berbeda
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  • Afiliasi tidak diketahui
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Rekan penulisOrganisasiArtikel bersama
Rina Nofri EnisUniversitas Jambi9
Nyimas Natasha Ayu ShafiraUniversitas Jambi8
Susan TarawifaUniversitas Jambi8
Amelia Dwi FitriUniversitas Jambi5
Citra MaharaniUniversitas Jambi5
Herlambang HerlambangUniversitas Jambi4
Herlambang HerlambangUniversitas Jambi3
Citra MaharaniAfiliasi tidak diketahui3
Rita HalimUniversitas Jambi2
Tia Wida Ekaputri HzUniversitas Jambi2
Tia Wida EkaputriUniversitas Jambi2
Erny KusdiyahUniversitas Jambi2
Wahyu Indah Dewi AuroraUniversitas Jambi2
Esa Indah AyudiaUniversitas Jambi2
Nabila Aulia TsaqifahSultan Ageng Tirtayasa University1
Rifdah HanifahSultan Ageng Tirtayasa University1
Firda Asma'ul HusnaSultan Ageng Tirtayasa University1
Mailani Dwi HidayatiSultan Ageng Tirtayasa University1
Ghea Farmaning Thias PutriSultan Ageng Tirtayasa University1
Ainina Al ShadrinaSultan Ageng Tirtayasa University1
Charles Apul SimanjuntakUniversitas Jambi1
Nys. Natasha Ayu SUniversitas Jambi1
Elfiani ElfianiUniversitas Jambi1
AuroraAfiliasi tidak diketahui1
Armaidi DarmawanUniversitas Jambi1
Patrick William GadingUniversitas Jambi1
Mara Imam Taufiq SiregarUniversitas Jambi1
Hafizah HafizahUniversitas Jambi1
Nindya AryantyUniversitas Jambi1
Anati PurwakanthiUniversitas Jambi1
HerlambangAfiliasi tidak diketahui1
Rita HalimUniversitas Jambi1
Dhea AssyifaAfiliasi tidak diketahui1
Ahmad SyauqyUniversitas Jambi1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/kedokteran/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Exploration The Multifaceted Role Of Vitamins In Epigenetic Regulation: Insights Into DNA Methylation And Histone Modification</dc:title>
	<dc:creator xml:lang="en">Perkasa, Tengku Arief Buana</dc:creator>
	<dc:creator xml:lang="en">Puspasari, Anggelia</dc:creator>
	<dc:creator xml:lang="en">Priskila, Loury</dc:creator>
	<dc:creator xml:lang="en">Tarigan, Nadir Putra Indra</dc:creator>
	<dc:creator xml:lang="en">Widyawati, Dwi</dc:creator>
	<dc:creator xml:lang="en">Neldi, Vina</dc:creator>
	<dc:subject xml:lang="en">Vitamins</dc:subject>
	<dc:subject xml:lang="en">Epigenetics</dc:subject>
	<dc:subject xml:lang="en">DNA Methylation</dc:subject>
	<dc:subject xml:lang="en">Histone Modification</dc:subject>
	<dc:subject xml:lang="en">Nutritional Epigenetics</dc:subject>
	<dc:subject xml:lang="en">Gene Expression</dc:subject>
	<dc:description xml:lang="en">Background: Recent research shows that vitamins actively regulate epigenetic mechanisms like DNA methylation and histone changes. Gene regulation, cellular differentiation, and disease development depend on these pathways. Aims: This review aims to synthesize current evidence on how vitamins A, B, C, D, E, and K influence epigenetic regulation, and to elucidate their potential roles in health maintenance and disease prevention.
Methods: NCBI and ScienceDirect were used to search English-language literature from 2015 to 2024 for a narrative review. To capture vitamins' direct and indirect impacts on epigenetic pathways, selected peer-reviewed papers were qualitatively examined.
Results: Vitamin A affects gene expression via receptor-mediated mechanisms which modify chromatin structure. B vitamins provide methyl donors for DNA methylation and histone changes. Vitamin C cofactors TET enzymes and histone demethylases, supporting active DNA demethylation and histone acetylation. The vitamin D receptor (VDR) affects DNA methyltransferases and histone-modifying enzymes, regulating gene transcription. Vitamins E and K modulate oxidative stress and histone changes to stabilize the epigenome, which may benefit cancer treatment and metabolic regulation.
Conclusion: Vitamins' diverse and linked epigenetic regulatory activities are highlighted.  These micronutrients may help prevent and treat cancer, metabolic problems, and developmental anomalies by maintaining genomic integrity and influencing gene expression.
Keywords: Vitamins, Epigenetics, DNA Methylation, Histone Modification, Nutritional Epigenetics, Gene Expression.</dc:description>
	<dc:publisher xml:lang="en">FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI</dc:publisher>
	<dc:date>2025-05-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/kedokteran/article/view/42536</dc:identifier>
	<dc:identifier>10.22437/jmj.v13i1.42536</dc:identifier>
	<dc:source xml:lang="en">Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan; Vol. 13 No. 1 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan; 76-90</dc:source>
	<dc:source>2580-6874</dc:source>
	<dc:source>2339-269X</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/kedokteran/article/view/42536/20989</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan</dc:rights>
</oai_dc:dc>