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Correlation of IL-10 Levels with the Bacterial Index in Multibacillary Leprosy

Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan · Vol. 13 No. 2 (2025) · hlm. 239–245

DOI
10.22437/jmj.v13i2.48898
ISSN
2580-6874, 2339-269X
Terbit
2025-11-12
Penerbit
FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI
Bahasa
en

Abstrak

Background: Multibacillary (MB) leprosy is characterised by a high bacillary burden and a tolerogenic immune profile. Interleukin-10 (IL-10) is a key immunoregulatory cytokine that may reflect bacillary load. Objective: To compare bacillary burden and IL-10 between MB patients and controls and to examine the correlation between the Bacterial Index (BI) and IL-10 among MB patients. Methods: A comparative cross-sectional study included 68 participants (MB n=34; controls n=34). Categorical variables were analysed using Chi-square tests, and medians were used with Mann–Whitney U tests. Spearman’s rank correlation was used to assess the BI–IL-10 relationship in MB. Results: Age distribution was similar between groups (p=0.451), whereas occupation (p=0.040) and education (p=0.027) differed. BI was markedly higher in MB than in controls (median 2.5 [IQR 4] vs 0 [0]; p<0.001). IL-10 concentrations were also higher in MB (1.96 [4.03] pg/mL) than in controls (1.12 [1.94] pg/mL; p=0.029). Among MB patients, BI correlated positively with IL-10 (ρ = 0.358; p = 0.038). Conclusion: MB leprosy shows substantially greater bacillary burden and elevated IL-10 relative to controls. The positive association between BI and IL-10 supports the role of an immunoregulatory milieu linked to bacillary load. These findings highlight IL-10 as a potential biomarker for disease burden in MB leprosy and warrant validation in larger, adjusted cohorts.

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  • Universitas Jambi
  • Sriwijaya University
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
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Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Rina Nofri EnisUniversitas Jambi4
Fairuz FairuzUniversitas Jambi3
Wahyu Indah Dewi AuroraUniversitas Jambi3
Mirna Marhami IskandarUniversitas Jambi3
Hanina HaninaUniversitas Jambi3
Putri Sari WulandariUniversitas Jambi3
Hasna DewiUniversitas Jambi3
Anggelia PuspasariUniversitas Jambi2
Susan TarawifaUniversitas Jambi2
Esa Indah AyudiaUniversitas Jambi2
Armaidi DarmawanUniversitas Jambi2
Melly MirandaAfiliasi tidak diketahui2
Rianita JuniatiAfiliasi tidak diketahui2
Andika SulistiawanUniversitas Jambi2
Hasna DewiAfiliasi tidak diketahui1
Nuriyah NuriyahAfiliasi tidak diketahui1
Nur Afni LestariAfiliasi tidak diketahui1
Regina Natasia UlfaUniversitas Jambi1
Makruf EfendyUniversitas Jambi1
Samsirun HalimAfiliasi tidak diketahui1
Huntari HarahapUniversitas Jambi1
Amelia Dwi FitriUniversitas Jambi1
Jelpa PeriantaloUniversitas Jambi1
Maria Estela KarolinaUniversitas Jambi1
Jurnal JmjAfiliasi tidak diketahui1
Erni KusdiyahAfiliasi tidak diketahui1
MIftakhul BaitiUniversitas Jambi1
Solha ElfridaAfiliasi tidak diketahui1
hasna dewiAfiliasi tidak diketahui1
Hanina HaninaSriwijaya University1
Tia Wida Ekaputri HzAfiliasi tidak diketahui1
Nyimas Natasha Ayu ShafiraUniversitas Jambi1
Citra MaharaniUniversitas Jambi1
Willia Novita Eka RiniUniversitas Jambi1

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Sumber metadata: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/kedokteran/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Correlation of IL-10 Levels with the Bacterial Index in Multibacillary Leprosy</dc:title>
	<dc:creator xml:lang="en">Fitriyanti, Fitriyanti</dc:creator>
	<dc:creator xml:lang="en">Lipinwati, Lipinwati</dc:creator>
	<dc:creator xml:lang="en">Istarini, Attiya</dc:creator>
	<dc:creator xml:lang="en">Ekaputri, Tia Wida</dc:creator>
	<dc:creator xml:lang="en">Nastiti, Niken Irfa</dc:creator>
	<dc:creator xml:lang="en">Adnyana, I Made Dwi Mertha</dc:creator>
	<dc:subject xml:lang="en">multibacillary leprosy</dc:subject>
	<dc:subject xml:lang="en">bacterial index</dc:subject>
	<dc:subject xml:lang="en">IL-10</dc:subject>
	<dc:description xml:lang="en">Background: Multibacillary (MB) leprosy is characterised by a high bacillary burden and a tolerogenic immune profile. Interleukin-10 (IL-10) is a key immunoregulatory cytokine that may reflect bacillary load. Objective: To compare bacillary burden and IL-10 between MB patients and controls and to examine the correlation between the Bacterial Index (BI) and IL-10 among MB patients.
Methods: A comparative cross-sectional study included 68 participants (MB n=34; controls n=34). Categorical variables were analysed using Chi-square tests, and medians were used with Mann–Whitney U tests. Spearman’s rank correlation was used to assess the BI–IL-10 relationship in MB.
Results: Age distribution was similar between groups (p=0.451), whereas occupation (p=0.040) and education (p=0.027) differed. BI was markedly higher in MB than in controls (median 2.5 [IQR 4] vs 0 [0]; p&amp;lt;0.001). IL-10 concentrations were also higher in MB (1.96 [4.03] pg/mL) than in controls (1.12 [1.94] pg/mL; p=0.029). Among MB patients, BI correlated positively with IL-10 (ρ = 0.358; p = 0.038).
Conclusion: MB leprosy shows substantially greater bacillary burden and elevated IL-10 relative to controls. The positive association between BI and IL-10 supports the role of an immunoregulatory milieu linked to bacillary load. These findings highlight IL-10 as a potential biomarker for disease burden in MB leprosy and warrant validation in larger, adjusted cohorts.</dc:description>
	<dc:publisher xml:lang="en">FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI</dc:publisher>
	<dc:date>2025-11-12</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/kedokteran/article/view/48898</dc:identifier>
	<dc:identifier>10.22437/jmj.v13i2.48898</dc:identifier>
	<dc:source xml:lang="en">Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan; Vol. 13 No. 2 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan; 239-245</dc:source>
	<dc:source>2580-6874</dc:source>
	<dc:source>2339-269X</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/kedokteran/article/view/48898/22494</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan</dc:rights>
</oai_dc:dc>