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Pengaruh Ekstrak Rebusan Daun Tithonia diversifolia (Hemsl.) A. Gray Terhadap Kadar Glukosa Darah

BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan · Vol. 7 No. 1 (2019) · hlm. 41–48

DOI
10.22373/biotik.v7i1.5470
ISSN
2549-1768, 2337-9812
Terbit
2019-11-28
Penerbit
Universitas Islam Negeri Ar-Raniry
Bahasa
eng

Abstrak

Tithonia diversifolia is a plant that has the potential to reduce blood glucose levels that is crucial in Diabetes Mellitus therapy. This study aims to determine the active compounds contained in the extract of T. diversifolia leaves decoction, the effect of decoction extract on the reduction of blood glucose, and the most effective decoction extract to reduce blood glucose levels as well. The study used a Completely Randomized Design (CRD) with the research treatment groups, namely: Kn = normal control (normal mice and not given leaves decoction extract), Ka = STZ control (DM mice, which are normal mice induced by 65mg/Kg of STZ), Kp = treatment control (normal mice given leaf decoction extract), P1 = DM + mice were given young leaf decoction extract, P2 = DM + mice were given a mixture of young leaf and adult leaf decoction extract, P3 = DM + mice were given adult leaf decoction extract. The leaves used for decoction were 1-6 leaves from the shoots. The analysis of T. diversifolia leaves decoction compounds is using the visible spectrophotometers for tannins, phenols and flavonoids and GC-MS for terpenoid analysis. The result found that Tithonia diversifolia leaves decoction extracts contain tannins, flavonoids and phenols, while terpenoids are not detected. The leaves decoction extracts of T. diversifolia influenced the decreases in blood glucose levels of DM mice, especially the decoction extract of adult leaves which reduced blood glucose levels to 71.16%.

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  • Universitas Gadjah Mada
  • Universitas Teuku Umar
  • National Institute of Technology and Evaluation
  • Justus-Liebig-Universität Gießen
  • Jenderal Soedirman University
  • Universitas Islam Negeri Raden Fatah Palembang
  • Universitas Islam Negeri Ar-Raniry
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Rekan penulisOrganisasiArtikel bersama
Aris Tri HaryantoUniversitas Gadjah Mada7
Tri WibawaUniversitas Gadjah Mada4
Michael KannJustus-Liebig-Universität Gießen3
Jaka WidadaUniversitas Gadjah Mada2
Hevi WihadmadyatamiUniversitas Gadjah Mada2
Diani MentariJenderal Soedirman University1
Rinawati RinawatiUniversitas Teuku Umar1
Sri Wahyuni MuhsinUniversitas Teuku Umar1
Siti Maisyaroh Fitri SiregarUniversitas Teuku Umar1
Ade OktasariUniversitas Islam Negeri Raden Fatah Palembang1
Muhammad AdnanUniversitas Islam Negeri Ar-Raniry1
Matin NuhamunadaUniversitas Gadjah Mada1
Lisna HidayatiUniversitas Gadjah Mada1
Hera NirwatiUniversitas Gadjah Mada1
Sp.A SutaryoUniversitas Gadjah Mada1
Nenny Sri MulyaniAfiliasi tidak diketahui1
Titis Budi WidowatiAfiliasi tidak diketahui1
Purnomo HadiAfiliasi tidak diketahui1
Abdul Rahman SiregarUniversitas Gadjah Mada1
Shinta HartantoUniversitas Gadjah Mada1
Sofia MubarikaUniversitas Gadjah Mada1
Camelia HerdiniUniversitas Gadjah Mada1
Bambang HariwiyantoUniversitas Gadjah Mada1
Akira HosoyamaNational Institute of Technology and Evaluation1
Atsushi YamazoeNational Institute of Technology and Evaluation1
Hideaki NojiriThe University of Tokyo1
M. MurwantokoAfiliasi tidak diketahui1
Ch. Retna HandayaniAfiliasi tidak diketahui1
Rarastoeti PratiwiUniversitas Gadjah Mada1
T. TrijokoUniversitas Gadjah Mada1
Aushia Tanzih Al HaqUniversitas Gadjah Mada1
Subagus WahyuonoUniversitas Gadjah Mada1
Tri Rini NuringtyasUniversitas Gadjah Mada1
Dian Ayuning TyasUniversitas Gadjah Mada1
Dewi Kartikawati ParamitaUniversitas Gadjah Mada1
Dyah WidiastutiNational Research and Innovation Agency1
Retno MurwantiUniversitas Gadjah Mada1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ar-raniry.ac.id/index.php/biotik/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Pengaruh Ekstrak Rebusan Daun Tithonia diversifolia  (Hemsl.) A. Gray Terhadap Kadar Glukosa Darah</dc:title>
	<dc:creator xml:lang="en">Rinawati, Rinawati</dc:creator>
	<dc:creator xml:lang="en">Suharyanto, E</dc:creator>
	<dc:creator xml:lang="en">Wijayanti, Nastiti</dc:creator>
	<dc:subject xml:lang="en">Tithonia diversifolia</dc:subject>
	<dc:subject xml:lang="en">leaves decoction extracts</dc:subject>
	<dc:subject xml:lang="en">Diabetes Mellitus.</dc:subject>
	<dc:description xml:lang="en">Tithonia diversifolia is a plant that has the potential to reduce blood glucose levels that is crucial in Diabetes Mellitus therapy. This study aims to determine the active compounds contained in the extract of T. diversifolia leaves decoction, the effect of decoction extract on the reduction of blood glucose, and the most effective decoction extract to reduce blood glucose levels as well. The study used a Completely Randomized Design (CRD) with the research treatment groups, namely: Kn = normal control (normal mice and not given leaves decoction extract), Ka = STZ control (DM mice, which are normal mice induced by 65mg/Kg of STZ), Kp = treatment control (normal mice given leaf decoction extract) , P1 = DM + mice were given young leaf decoction extract, P2 = DM + mice were given a mixture of young leaf and adult leaf decoction extract, P3 = DM + mice were given adult leaf decoction extract. The leaves used for decoction were 1-6 leaves from the shoots. The analysis of T. diversifolia leaves decoction compounds is using the visible spectrophotometers for tannins, phenols and flavonoids and GC-MS for terpenoid analysis. The result found that Tithonia diversifolia leaves decoction extracts contain tannins, flavonoids and phenols, while terpenoids are not detected. The leaves decoction extracts of T. diversifolia influenced the decreases in blood glucose levels of DM mice, especially the decoction extract of adult leaves which reduced blood glucose levels to 71.16%.</dc:description>
	<dc:publisher xml:lang="en">Universitas Islam Negeri Ar-Raniry</dc:publisher>
	<dc:date>2019-11-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jurnal.ar-raniry.ac.id/index.php/biotik/article/view/5470</dc:identifier>
	<dc:identifier>10.22373/biotik.v7i1.5470</dc:identifier>
	<dc:source xml:lang="en">BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan; Vol. 7 No. 1 (2019): JURNAL BIOTIK; 41-48</dc:source>
	<dc:source xml:lang="id">Biotik; Vol 7 No 1 (2019): JURNAL BIOTIK; 41-48</dc:source>
	<dc:source>2549-1768</dc:source>
	<dc:source>2337-9812</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jurnal.ar-raniry.ac.id/index.php/biotik/article/view/5470/3530</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2019 BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan</dc:rights>
</oai_dc:dc>