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NEPHROPROTECTIVE OF ETHANOL EXTRACT OF Annona muricata L. BARK ON PARACETAMOL-INDUCED NEPHROTOXICITY IN RATS

BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan · Vol. 11 No. 1 (2023) · hlm. 66–75

DOI
10.22373/biotik.v11i1.15635
ISSN
2549-1768, 2337-9812
Terbit
2023-05-09
Penerbit
Universitas Islam Negeri Ar-Raniry
Bahasa
eng

Abstrak

Kidneys are organs that have the potential for damage caused by toxic substances. The use of paracetamol in high doses or long-term therapeutic doses can cause adverse effects in the form of damage to the kidneys. Plants that have the potential to become medicinal raw materials against kidney damage are Annona muricata L. The purpose of this study was to determine the potential protection of ethanolic extract of soursop bark (EESB) against histopathological rat kidney induced by toxic doses of paracetamol. This study used an experimental method using a completely randomized design (CRD). The normal control group (K0) and negative control (K-) were given distilled water, while in the treatment group the doses of EESB were 150, 300 and 600 mg/kgBW dissolved in 1 ml of distilled water for 14 days. On the 7th day, all groups of rats were given paracetamol at a dose of 1350 mg/kgBW except for the K0 group. Each group was 5 repetitions, so that in this study used 25 rats (Rattus norvegicus L.). Samples of kidney organs were taken on the 14th day to observe the histopathological structure of the tubular cells undergoing necrosis. The results showed that at a dose of 300 mg/kgBW EESB had the potential for protection against kidney histopathology by suppressing the occurrence of cell death (necrosis).Keywords: Soursop bark, kidney, paracetamol, necrosis

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  • Universitas Syiah Kuala
  • State University of Semarang
  • Sunan Gunung Djati State Islamic University Bandung
  • Universitas Islam Negeri Raden Fatah Palembang
  • Universitas Islam Negeri Ar-Raniry
  • Akademi Kebidanan Bunga Husada
  • Universitas Ahmad Dahlan
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Rekan penulisOrganisasiArtikel bersama
Novi Yana SariUniversitas Syiah Kuala2
Kartono KartonoState University of Semarang1
Endang Retno WinartiState University of Semarang1
Syafrizal SyafrizalUniversitas Islam Negeri Ar-Raniry1
Zuriana SiregarUniversitas Syiah Kuala1
Novia D AstariUniversitas Syiah Kuala1
Tatiana TatianaUniversitas Syiah Kuala1
Muhammad Ali SarongUniversitas Syiah Kuala1
Fauziah FauziahAkademi Kebidanan Bunga Husada1
Eka SafitriUniversitas Syiah Kuala1
Fajar DiniUniversitas Syiah Kuala1
Nanda KhirnaUniversitas Syiah Kuala1
ULIL HASRI DESFIANAUniversitas Syiah Kuala1
SunartiAfiliasi tidak diketahui1
Mufidah Eka PutriUniversitas Syiah Kuala1
Intan Wulan OkaviaUniversitas Syiah Kuala1
Ria CerianaUniversitas Syiah Kuala1
Sunarti SunartiUniversitas Ahmad Dahlan1
Amiripana AmiripanaAfiliasi tidak diketahui1
Retno RiyaningtyasAfiliasi tidak diketahui1
Iwan Caca GunawanSunan Gunung Djati State Islamic University Bandung1
Asep FuadSunan Gunung Djati State Islamic University Bandung1
Abdul Basir MohamadNational University of Malaysia1
Abdul Haq SyawqiUniversitas Islam Negeri Madura1
Muhamad Farhin HarunUniversitas Islam Negeri Raden Fatah Palembang1
Muhamad Sadi IsUniversitas Islam Negeri Raden Fatah Palembang1
Awatiful AzzaUniversitas Muhammadiyah Jember1
Trias SetyowatiAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ar-raniry.ac.id/index.php/biotik/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">NEPHROPROTECTIVE OF ETHANOL EXTRACT OF Annona muricata L. BARK ON PARACETAMOL-INDUCED NEPHROTOXICITY IN RATS</dc:title>
	<dc:creator xml:lang="en">Sari, Widya</dc:creator>
	<dc:creator xml:lang="en">Masykur, Masykur</dc:creator>
	<dc:creator xml:lang="en">Adhilla, Farah</dc:creator>
	<dc:creator xml:lang="en">Maisarah, Rojatul</dc:creator>
	<dc:creator xml:lang="en">Fauziah, Fauziah</dc:creator>
	<dc:subject xml:lang="en">Soursop bark</dc:subject>
	<dc:subject xml:lang="en">kidney</dc:subject>
	<dc:subject xml:lang="en">paracetamol</dc:subject>
	<dc:subject xml:lang="en">necrosis</dc:subject>
	<dc:description xml:lang="en">Kidneys are organs that have the potential for damage caused by toxic substances. The use of paracetamol in high doses or long-term therapeutic doses can cause adverse effects in the form of damage to the kidneys. Plants that have the potential to become medicinal raw materials against kidney damage are Annona muricata L. The purpose of this study was to determine the potential protection of ethanolic extract of soursop bark (EESB) against histopathological rat kidney induced by toxic doses of paracetamol. This study used an experimental method using a completely randomized design (CRD). The normal control group (K0) and negative control (K-) were given distilled water, while in the treatment group the doses of EESB were 150, 300 and 600 mg/kgBW dissolved in 1 ml of distilled water for 14 days. On the 7th day, all groups of rats were given paracetamol at a dose of 1350 mg/kgBW except for the K0 group. Each group was 5 repetitions, so that in this study used 25 rats (Rattus norvegicus L.). Samples of kidney organs were taken on the 14th day to observe the histopathological structure of the tubular cells undergoing necrosis. The results showed that at a dose of 300 mg/kgBW EESB had the potential for protection against kidney histopathology by suppressing the occurrence of cell death (necrosis).Keywords: Soursop bark, kidney, paracetamol, necrosis</dc:description>
	<dc:publisher xml:lang="en">Universitas Islam Negeri Ar-Raniry</dc:publisher>
	<dc:date>2023-05-09</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jurnal.ar-raniry.ac.id/index.php/biotik/article/view/15635</dc:identifier>
	<dc:identifier>10.22373/biotik.v11i1.15635</dc:identifier>
	<dc:source xml:lang="en">BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan; Vol. 11 No. 1 (2023): JURNAL BIOTIK; 66-75</dc:source>
	<dc:source xml:lang="id">Biotik; Vol 11 No 1 (2023): JURNAL BIOTIK; 66-75</dc:source>
	<dc:source>2549-1768</dc:source>
	<dc:source>2337-9812</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jurnal.ar-raniry.ac.id/index.php/biotik/article/view/15635/pdf</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2023 Widya - Sari</dc:rights>
</oai_dc:dc>