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Cytotoxic Activity of Aporphine Alkaloids from Alseodaphne Peduncularis (Wall. Ex. Ness) Meissn against Hela Cell Line

Circuit: Jurnal Ilmiah Pendidikan Teknik Elektro · Vol. 1 No. 2 (2016)

DOI
10.22373/crc.v1i2.769
ISSN
2549-3701, 2549-3698
Terbit
2016-01-02
Penerbit
PTE FTK UIN Ar-Raniry
Bahasa
eng

Abstrak

Genus of Alseodaphne has been known as a source of apoprhine alkaloid that displayed potent cytotoxic activities against selected cell lines. Two aporphine alkaloids, Corydine 1 and norlirioferine 2 were isolated from leaves of Alseodaphne peduncularis (Wall. Ex. Ness) Meissn. (Lauraceae). Phytochemical study involved extraction, separation and purification by using various chromatography methods and structural elucidation by using spectoscopic techniques such as UV, IR LC-MS and 1D and 2D NMR. These compounds were then assayed for cytotoxicity against human uteric cervical tumor (heLa) and compare for safety with normal mouse fibroblast (NIH/3T3) cell lines by using the MTT assay. Compound 2 displayed potent cytotoxic activities against heLa cell, but compound 1 showed as inactive. Both compounds have no significant effect against NIH/3T3 cell lines indicated good for cancer agent treatment.

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16 penulis · 44 tautan kepenulisan bersama · 19 lintas organisasi

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  • Sultan Idris Education University
  • Samudra University
  • Mulawarman University
  • Tunku Abdul Rahman University of Management and Technology
  • Universitas Mathla'ul Anwar Banten
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Rekan penulisOrganisasiArtikel bersama
Supriatno SalamSultan Idris Education University2
Puji WahyuningsihSamudra University1
Halimatussakdiah HalimatussakdiahSamudra University1
Furqan Nur IhsanSamudra University1
Baso Didik HikmawanAfiliasi tidak diketahui1
Islamudin AhmadMulawarman University1
Laode RijaiMulawarman University1
Erwin SamsulMulawarman University1
Herman HermanMulawarman University1
Tarso RudianaUniversitas Mathla'ul Anwar Banten1
Noor Hazlina IbrahımSultan Idris Education University1
Muhammad Hafiz Husna HasnanSultan Idris Education University1
Siow-Ping TanTunku Abdul Rahman University of Management and Technology1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ar-raniry.ac.id/index.php/circuit/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Cytotoxic Activity of Aporphine Alkaloids from Alseodaphne Peduncularis (Wall. Ex. Ness) Meissn against Hela Cell Line</dc:title>
	<dc:creator xml:lang="en">Amna, Ulil</dc:creator>
	<dc:creator xml:lang="en">Ahmad, Kartini</dc:creator>
	<dc:creator xml:lang="en">Nafiah, Mohd Azlan</dc:creator>
	<dc:subject xml:lang="en">Lauraceae</dc:subject>
	<dc:subject xml:lang="en">Alseodaphne peduncularis</dc:subject>
	<dc:subject xml:lang="en">Aporphinoid</dc:subject>
	<dc:subject xml:lang="en">Cytotoxic</dc:subject>
	<dc:description xml:lang="en">Genus of Alseodaphne has been known as a source of apoprhine alkaloid that displayed potent cytotoxic activities against selected cell lines. Two aporphine alkaloids, Corydine 1 and norlirioferine 2 were isolated from leaves of Alseodaphne peduncularis (Wall. Ex. Ness) Meissn. (Lauraceae). Phytochemical study involved extraction, separation and purification by using various chromatography methods and structural elucidation by using spectoscopic techniques such as UV, IR LC-MS and 1D and 2D NMR. These compounds were then assayed for cytotoxicity against human uteric cervical tumor (heLa) and compare for safety with normal mouse fibroblast (NIH/3T3) cell lines by using the MTT assay. Compound 2 displayed potent cytotoxic activities against heLa cell, but compound 1 showed as inactive. Both compounds have no significant effect against NIH/3T3 cell lines indicated good for cancer agent treatment.</dc:description>
	<dc:publisher xml:lang="en">PTE FTK UIN Ar-Raniry</dc:publisher>
	<dc:date>2016-01-02</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jurnal.ar-raniry.ac.id/index.php/circuit/article/view/769</dc:identifier>
	<dc:identifier>10.22373/crc.v1i2.769</dc:identifier>
	<dc:source xml:lang="en">Circuit: Jurnal Ilmiah Pendidikan Teknik Elektro; Vol. 1 No. 2 (2015)</dc:source>
	<dc:source>2549-3701</dc:source>
	<dc:source>2549-3698</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jurnal.ar-raniry.ac.id/index.php/circuit/article/view/769/601</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2016 CIRCUIT</dc:rights>
</oai_dc:dc>