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A Comprehensive Analysis of Metabolite Profile and Phytochemical Composition of Ulva lactuca Macroalgae From The Coast of Banda Aceh, Indonesia

Elkawnie · Vol. 11 No. 2 (2025) · pp. 1–15

DOI
10.22373/ekw.v11i2.25403
ISSN
2460-8912, 2460-8920
Published
2025-12-10
Publisher
Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry
Language
eng
License
creativecommons.org/licenses/by-nc-sa/4.0

Abstract

Abstract: Marine macroalgae are known for their rich bioactive compounds, offering various pharmacological benefits. This research was conducted to analyze the phytochemical composition and metabolite profiles of Ulva lactuca, a marine macroalgae, along the coastal region of Banda Aceh, Indonesia. The research methodology encompassed three primary phases: assessment of antioxidant scavenging activity, determination of phytochemical composition, and in vivo metabolite profiling. The extract exhibited notable antioxidant activity, evidenced by its 47.22% inhibition rate. Spectral analysis via FTIR revealed prominent peaks at 1019 cm−1, 1654 cm−1, and 3352 cm−1, indicative of the presence of ethers, carbonyls, and hydroxyl groups, respectively. GC-MS analysis, coupled with a literature review, identified a total of 30 phytochemical compounds within Ulva lactuca, several of which possess significant bioactive properties with potential applications as antibacterial agents in both human and animal contexts. Consequently, Ulva lactuca demonstrates promising prospects as a source of antibacterial agents. The implications of this study suggest that Ulva lactuca could be developed as a natural alternative for antibacterial treatments, potentially reducing dependence on synthetic antibiotics in both healthcare and aquaculture industries. Abstrak: Makroalga dikenal karena kandungan senyawa bioaktifnya yang kaya, yang menawarkan berbagai manfaat farmakologis. Penelitian ini dilakukan untuk menganalisis komposisi fitokimia dan profil metabolit dari Ulva lactuca di sepanjang wilayah pesisir Banda Aceh, Indonesia. Metodologi penelitian mencakup tiga fase utama: penilaian aktivitas antioksidan, penentuan komposisi fitokimia, dan profil metabolit in vivo. Ekstrak menunjukkan aktivitas antioksidan yang signifikan, dibuktikan dengan tingkat inhibisi sebesar 47,22%. Analisis spektral menggunakan FTIR mengungkapkan puncak pada 1019 cm−1, 1654 cm−1, dan 3352 cm−1, yang menunjukkan adanya gugus eter, karbonil, dan hidroksi. Analisis GC-MS, yang dipadukan dengan tinjauan literatur, mengidentifikasi total 30 senyawa fitokimia dalam Ulva lactuca, beberapa di antaranya memiliki sifat bioaktif signifikan dengan potensi aplikasi sebagai agen antibakteri dalam konteks manusia dan hewan. Dengan demikian, Ulva lactuca menunjukkan prospek yang menjanjikan sebagai sumber agen antibakteri. Implikasi dari penelitian ini menunjukkan bahwa Ulva lactuca dapat dikembangkan sebagai alternatif alami untuk pengobatan antibakteri, yang berpotensi mengurangi ketergantungan pada antibiotik sintetis dalam industri kesehatan dan akuakultur.

Keywords

Collaboration network of the authors

40 authors · 105 co-authorship links · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • University of Brawijaya
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Yusrizal AkmalAffiliation unknown6
Mustari MustariAffiliation unknown2
Arif SardiAffiliation unknown2
Muliari MuliariAffiliation unknown2
Hasby HasbyAffiliation unknown2
Epa PaujiahAffiliation unknown2
Riana MulthazamAffiliation unknown1
Marhawati MarhawatiAffiliation unknown1
Muh. Ihsan SaidAffiliation unknown1
Syamsu RijalAffiliation unknown1
Nur AnaAffiliation unknown1
Muhammad DinarAffiliation unknown1
Fatmawati SaifuddinAffiliation unknown1
Rhindira HumairaniAffiliation unknown1
R Nurlian R NurlianAffiliation unknown1
Baihaqi BaihaqiAffiliation unknown1
Muslich HidayatAffiliation unknown1
Mujibul RahmanAffiliation unknown1
Fitriya NandaAffiliation unknown1
Nispi MawaddahAffiliation unknown1
Mima YuriatiAffiliation unknown1
Nurhafidhah NurhafidhahAffiliation unknown1
Mahyana MahyanaAffiliation unknown1
Yunina RahmiAffiliation unknown1
Rumondang RumondangAffiliation unknown1
Latifah HanumUniversity of Brawijaya1
Rahmad Rizki FazliAffiliation unknown1
Mieke AlvionitaAffiliation unknown1
Hanis Kusumawati RahayuAffiliation unknown1
Fitria Nelda FautamaAffiliation unknown1
Adian Aristia AnasAffiliation unknown1
Muhammad RezaAffiliation unknown1
Muammar YulianAffiliation unknown1
Nofa RamadaniAffiliation unknown1
Rosi HamamaAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://jurnal.ar-raniry.ac.id/index.php/elkawnie/oai, first harvested 7 Nov 2026, last seen 7 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">A Comprehensive Analysis of Metabolite Profile and Phytochemical Composition of Ulva lactuca Macroalgae From The Coast of Banda Aceh, Indonesia</dc:title>
	<dc:creator xml:lang="en">Akbar, Said Ali</dc:creator>
	<dc:creator xml:lang="en">Hasan, Muhammad</dc:creator>
	<dc:creator xml:lang="en">Afriani, Sari</dc:creator>
	<dc:creator xml:lang="en">Nuzlia, Cut</dc:creator>
	<dc:creator xml:lang="en">Zulfahmi, Ilham</dc:creator>
	<dc:subject xml:lang="en">antibacterial</dc:subject>
	<dc:subject xml:lang="en">antioxidant activity</dc:subject>
	<dc:subject xml:lang="en">macroalgae</dc:subject>
	<dc:subject xml:lang="en">phytochemical profiling</dc:subject>
	<dc:subject xml:lang="en">Ulva lactuca</dc:subject>
	<dc:description xml:lang="en">Abstract: Marine macroalgae are known for their rich bioactive compounds, offering various pharmacological benefits. This research was conducted to analyze the phytochemical composition and metabolite profiles of Ulva lactuca, a marine macroalgae, along the coastal region of Banda Aceh, Indonesia. The research methodology encompassed three primary phases: assessment of antioxidant scavenging activity, determination of phytochemical composition, and in vivo metabolite profiling. The extract exhibited notable antioxidant activity, evidenced by its 47.22% inhibition rate. Spectral analysis via FTIR revealed prominent peaks at 1019 cm−1, 1654 cm−1, and 3352 cm−1, indicative of the presence of ethers, carbonyls, and hydroxyl groups, respectively. GC-MS analysis, coupled with a literature review, identified a total of 30 phytochemical compounds within Ulva lactuca, several of which possess significant bioactive properties with potential applications as antibacterial agents in both human and animal contexts. Consequently, Ulva lactuca demonstrates promising prospects as a source of antibacterial agents. The implications of this study suggest that Ulva lactuca could be developed as a natural alternative for antibacterial treatments, potentially reducing dependence on synthetic antibiotics in both healthcare and aquaculture industries.
Abstrak: Makroalga dikenal karena kandungan senyawa bioaktifnya yang kaya, yang menawarkan berbagai manfaat farmakologis. Penelitian ini dilakukan untuk menganalisis komposisi fitokimia dan profil metabolit dari Ulva lactuca di sepanjang wilayah pesisir Banda Aceh, Indonesia. Metodologi penelitian mencakup tiga fase utama: penilaian aktivitas antioksidan, penentuan komposisi fitokimia, dan profil metabolit in vivo. Ekstrak menunjukkan aktivitas antioksidan yang signifikan, dibuktikan dengan tingkat inhibisi sebesar 47,22%. Analisis spektral menggunakan FTIR mengungkapkan puncak pada 1019 cm−1, 1654 cm−1, dan 3352 cm−1, yang menunjukkan adanya gugus eter, karbonil, dan hidroksi. Analisis GC-MS, yang dipadukan dengan tinjauan literatur, mengidentifikasi total 30 senyawa fitokimia dalam Ulva lactuca, beberapa di antaranya memiliki sifat bioaktif signifikan dengan potensi aplikasi sebagai agen antibakteri dalam konteks manusia dan hewan. Dengan demikian, Ulva lactuca menunjukkan prospek yang menjanjikan sebagai sumber agen antibakteri. Implikasi dari penelitian ini menunjukkan bahwa Ulva lactuca dapat dikembangkan sebagai alternatif alami untuk pengobatan antibakteri, yang berpotensi mengurangi ketergantungan pada antibiotik sintetis dalam industri kesehatan dan akuakultur.
 </dc:description>
	<dc:publisher xml:lang="en">Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry</dc:publisher>
	<dc:date>2025-12-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jurnal.ar-raniry.ac.id/index.php/elkawnie/article/view/25403</dc:identifier>
	<dc:identifier>10.22373/ekw.v11i2.25403</dc:identifier>
	<dc:source xml:lang="en">Elkawnie; Vol. 11 No. 2 (2025); 1-15</dc:source>
	<dc:source>2460-8912</dc:source>
	<dc:source>2460-8920</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jurnal.ar-raniry.ac.id/index.php/elkawnie/article/view/25403/12193</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Said Ali Akbar, Muhammad Hasan, Sari Afriani, Cut Nuzlia, Ilham Zulfahmi</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
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