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Anticancer Potency of Dimethyl 2-(2-Hydroxy-2-Methoxypropilidine) Malonate in Kombucha

Jurnal Biodjati · Vol. 7 No. 1 (2022) · pp. 86–94

DOI
10.15575/biodjati.v7i1.14634
ISSN
2541-4208, 2548-1606
Published
2022-05-30
Publisher
UIN Sunan Gunung Djati Bandung
Language
eng

Abstract

Kombucha has an anticancer potency because it has dimethyl 2-(2-hydroxy-2-methoxypropilidine) malonate compound. The research aimed to verify the compound dimethyl 2-(2-hydroxy-2-methoxypropilidine) malonate as an anticancer with the in-silico method, namely the molecular docking approach, drug likeness profile, and ADMET test. The tools used were the PyRx, Discovery Studio Visualizer, Sanjeevini, and pkCSM. The research material consisted of 3D Dimethyl 2-(2-Hydroxy-2-Methoxypropilidine) Malonate and Epidermal Growth Factor Receptor (EGFR). The analysis showed Dimethyl 2-(2-Hydroxy-2-Methoxypropilidine) Malonate is safe for consumption and can suppress cancer cells.Â

Keywords

Collaboration network of the authors

40 authors · 115 co-authorship links · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • Padjadjaran University
  • Universitas Islam Nahdlatul Ulama Jepara
  • Universitas Halu Oleo
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Hari HariadiAffiliation unknown3
Iman HernamanPadjadjaran University3
Astuti KusumoriniAffiliation unknown3
Muhammad AndryAffiliation unknown2
M. Fariz FadillahAffiliation unknown2
Tri CahyantoAffiliation unknown2
Ateng SupriyatnaAffiliation unknown2
sumiyati Sa’adahAffiliation unknown2
Musa'adah Musa'adahAffiliation unknown1
Adisty Virakawugi DarniwaAffiliation unknown1
Muna MumtazahAffiliation unknown1
Muhammad Wisnu BurhanuddinAffiliation unknown1
Ahmad Zaenal EpendiAffiliation unknown1
Anita AfrianingsihUniversitas Islam Nahdlatul Ulama Jepara1
Yushinta Eka FaridaAffiliation unknown1
Chee Chew SimAffiliation unknown1
Shams U Rehman KhanAffiliation unknown1
Boima SitumeangAffiliation unknown1
Muhammad Mutfi Amin ShidqiAffiliation unknown1
Barolym Tri PamungkasAffiliation unknown1
Lucky Dita AgustiansyahAffiliation unknown1
Fajar HidayantoAffiliation unknown1
Ayu SafitriUniversitas Halu Oleo1
Maharani MaharaniAffiliation unknown1
Ucu Wandi SomantriAffiliation unknown1
Isti Dwi PruschiaAffiliation unknown1
Dwiyarina MargarisaAffiliation unknown1
Khairani FitriAffiliation unknown1
Tetty Noverita KhairaniAffiliation unknown1
Muhammad Amin NasutionAffiliation unknown1
Muhammad Fauzan LubisAffiliation unknown1
Jashima UkhtiaAffiliation unknown1
Asysyifa RianaAffiliation unknown1
Yuliati WidiastutiAffiliation unknown1
Iriyanti HarunAffiliation unknown1
Galuh Chandra IrawanAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.uinsgd.ac.id/index.php/biodjati/oai, first harvested 7 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Anticancer Potency of Dimethyl 2-(2-Hydroxy-2-Methoxypropilidine) Malonate in Kombucha</dc:title>
	<dc:creator>Taupiqurrohman, Opik</dc:creator>
	<dc:creator>Rezaldi, Firman</dc:creator>
	<dc:creator>Amalia, Dina</dc:creator>
	<dc:creator>Suryani, Yani</dc:creator>
	<dc:subject xml:lang="en-US">dimethyl 2- (2-Hydroxy-2-Methoxypropilidine) malonate</dc:subject>
	<dc:subject xml:lang="en-US">EGFR</dc:subject>
	<dc:subject xml:lang="en-US">in silico</dc:subject>
	<dc:subject xml:lang="en-US">Kombucha</dc:subject>
	<dc:description xml:lang="en-US">Kombucha has an anticancer potency because it has dimethyl 2-(2-hydroxy-2-methoxypropilidine) malonate compound. The research aimed to verify the compound dimethyl 2-(2-hydroxy-2-methoxypropilidine) malonate as an anticancer with the in-silico method, namely the molecular docking approach, drug likeness profile, and ADMET test. The tools used were the PyRx, Discovery Studio Visualizer, Sanjeevini, and pkCSM. The research material consisted of 3D Dimethyl 2-(2-Hydroxy-2-Methoxypropilidine) Malonate and Epidermal Growth Factor Receptor (EGFR). The analysis showed Dimethyl 2-(2-Hydroxy-2-Methoxypropilidine) Malonate is safe for consumption and can suppress cancer cells. </dc:description>
	<dc:publisher xml:lang="en-US">UIN Sunan Gunung Djati Bandung</dc:publisher>
	<dc:date>2022-05-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.uinsgd.ac.id/index.php/biodjati/article/view/14634</dc:identifier>
	<dc:identifier>10.15575/biodjati.v7i1.14634</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Biodjati; Vol. 7 No. 1 (2022): May; 86-94</dc:source>
	<dc:source xml:lang="id-ID">Jurnal Biodjati; Vol 7 No 1 (2022): May; 86-94</dc:source>
	<dc:source>2541-4208</dc:source>
	<dc:source>2548-1606</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.uinsgd.ac.id/index.php/biodjati/article/view/14634/7168</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 J</dc:rights>
</oai_dc:dc>