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Tranexamic Acid in the Management of Upper Gastrointestinal Bleeding: an Evidence-based Case Report

ACTA MEDICA INDONESIANA · Vol. 47 No. 2 (2015)

ISSN
2338-2732, 0125-9326
Published
2015-04-01
Publisher
The Indonesian Society of Internal Medicine
Language
eng

Abstract

Aim: to review the effectiveness of tranexamic acid therapy which has been proposed to reduce bleeding and in turn lower mortality rate. Methods: following literature searching based on our clinical question on Cochrane Library, PubMed, Clinical Key, EBSCO, Science Direct and Proquest, one systematic review that includes seven randomized controlled trials is obtained. The article meets validity and relevance criteria. Results: the systematic review found that there is no any clear evidence between intervention and control groups in term of mortality. Conclusion: the use of tranexamic acid to reduce mortality in patients with upper gastrointestinal bleeding is not recommended. Key words: tranexamic acid, mortality, upper gastrointestinal bleeding.

Collaboration network of the authors

40 authors · 179 co-authorship links · showing the 40 most connected

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Co-authorOrganisationJoint articles
Kaka RenaldiAffiliation unknown4
Achmad FauziAffiliation unknown3
Dadang MakmunAffiliation unknown3
Cosphiadi IrawanAffiliation unknown3
Murdani AbdullahAffiliation unknown3
Hamzah ShatriAffiliation unknown3
Marcellus SimadibrataAffiliation unknown2
Lisnawati LisnawatiAffiliation unknown2
Eric Daniel TendaAffiliation unknown2
Mira YuliantiAffiliation unknown2
I Putu Eka Krisnha WijayaAffiliation unknown2
Christian JohanAffiliation unknown2
Herikurniawan HerikurniawanAffiliation unknown2
Muchtaruddin MansyurAffiliation unknown2
Achmad Fauzi KamalAffiliation unknown2
Marlinda AdhamAffiliation unknown2
Mardiah Suci HardiantiAffiliation unknown2
Thariqah SalamahAffiliation unknown2
Cleopas Martin RumendeAffiliation unknown2
Sukamto SukamtoAffiliation unknown2
Juferdy KurniawanAffiliation unknown2
Ceva W PitoyoAffiliation unknown1
Wuryantoro WuryantoroAffiliation unknown1
Zulkifli AminAffiliation unknown1
Valy WulaniAffiliation unknown1
Cleopas M RumendeAffiliation unknown1
Rabbinu R PribadiAffiliation unknown1
Ari F SyamAffiliation unknown1
Amanda P UtariAffiliation unknown1
Reyhan Eddy YunusAffiliation unknown1
Ari Fahrial SyamAffiliation unknown1
Muhammad Begawan BestariAffiliation unknown1
Roy SutiknoAffiliation unknown1
Wulyo RajabtoAffiliation unknown1
Calvin Kurnia MulyadiAffiliation unknown1
Vitya ChandikaAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Tranexamic Acid in the Management of Upper Gastrointestinal Bleeding: an Evidence-based Case Report</dc:title>
	<dc:creator>Atikah, Nur</dc:creator>
	<dc:creator>Singh, Gurmeet</dc:creator>
	<dc:creator>Maulahela, Hasan</dc:creator>
	<dc:creator>Cahyanur, Rahmat</dc:creator>
	<dc:description xml:lang="en-US">Aim: to review the effectiveness of tranexamic acid therapy which has been proposed to reduce bleeding and in turn lower mortality rate. Methods: following literature searching based on our clinical question on Cochrane Library, PubMed, Clinical Key, EBSCO, Science Direct and Proquest, one systematic review that includes seven randomized controlled trials is obtained. The article meets validity and relevance criteria. Results: the systematic review found that there is no any clear evidence between intervention and control groups in term of mortality. Conclusion: the use of tranexamic acid to reduce mortality in patients with upper gastrointestinal bleeding is not recommended. Key words: tranexamic acid, mortality, upper gastrointestinal bleeding.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2015-04-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/54</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 47 No. 2 (2015)</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/54/50</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2016 Indonesian Journal of internal Medicine</dc:rights>
</oai_dc:dc>