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Low Plasma Atherogenic Index Associated with Poor Prognosis in Hospitalized Patients with Acute Myocardial Infarction

ACTA MEDICA INDONESIANA · Vol. 48 No. 2 (2016) · pp. 106–113

ISSN
2338-2732, 0125-9326
Published
2016-09-21
Publisher
The Indonesian Society of Internal Medicine
Language
eng

Abstract

Aim: the impact of atherogenic index of plasma (AIP), calculated as logarithmic of triglyceride:HDL ratio (log10.[TG:HDL]), on major adverse cardiovascular events (MACE) during acute myocardial infarction (AMI) has not been fully accepted. This study aims to investigate the role of AIP in predicting major adverse cardiovascular events following AMI during intensive care in the hospital. Methods: this was a prospective cohort study. We enrolled subjects with AMI hospitalized in intensive coronary care unit at Dr. Sardjito General Hospital, Yogyakarta. The AIP was measured in fasting blood within 24 hours of hospital admission. The total cholesterol, LDL, HDL, and triglyceride (TG), were measured and AIP value was determined as log10.[TG:HDL]). Based on AIP value, subjects were allocated into low AIP (<0.24) and high AIP (≥0.24). The outcome of the study was major adverse cardiovascular events during hospitalization, i.e. multipart of all cause mortality, acute heart failure, cardiogenic shock, reinfarction, and rescucitated VT/VF. Results: among 277 subjects, the high AIP group comprised 213 subjects (77%) and low AIP group comprised 64 subjects (33%). During intensive hospitalisation, 66 subjects (24%) developed MACE and 20 subjects (7%) developed fatal outcome (all cause mortality). The incidence of MACE tended to be higher in low AIP group, however its difference was not significant. The incidence of all cause mortality was significantly higher in low AIP group (14%) than in high AIP group (5%). Multivariable analysis showed that low AIP predicted all cause mortality independently with a risk ratio 3.71 (95% CI 1.26 – 10.97, p=0.02). Conclusion: low AIP value (<0.24) is an independent predictor for all cause mortality in patients with acute myocardial infarction undergoing intensive hospitalisation.

Keywords

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Lucida Kris DinartiAffiliation unknown1
Abdul S WahabAffiliation unknown1
Nahar TaufiqAffiliation unknown1
Heri HernawanAffiliation unknown1
Dyah Wulan AnggrahiniAffiliation unknown1
Muhammad Gahan SatwikoAffiliation unknown1
Arditya DamarkusumaAffiliation unknown1
Armalya PritazahraAffiliation unknown1
Muhammad Reyhan HadwionoAffiliation unknown1
Vera Christina DewantoAffiliation unknown1
Salvatore Di SommaAffiliation unknown1
Noriaki EmotoAffiliation unknown1
Lucia Kris DinartiAffiliation unknown1
Hermawan SusantoAffiliation unknown1
Hayatun NufusAffiliation unknown1
Darmadi DarmadiAffiliation unknown1
Andhika RachmanAffiliation unknown1
Nur SamsuAffiliation unknown1
Lugyanti SukrismanAffiliation unknown1
Rudy HidayatAffiliation unknown1
Evy YunihastutiAffiliation unknown1
Simon SalimAffiliation unknown1
Eka GinanjarAffiliation unknown1
Sally Aman NasutionAffiliation unknown1
Ervita RitongaAffiliation unknown1
Ceva Wicaksono PitoyoAffiliation unknown1
Andi Makbul AmanAffiliation unknown1
Cecilia hendrattaAffiliation unknown1
Adityo SusiloAffiliation unknown1
Hery Djagat PurnomoAffiliation unknown1
Radiyati Umi PartanAffiliation unknown1
Selfie SelfieAffiliation unknown1
Gede Wira MahaditaAffiliation unknown1
Azzaki AbubakarAffiliation unknown1
Wachid PutrantoAffiliation unknown1
Reinaldo AlexanderAffiliation unknown1
Dani RosdianaAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Low Plasma Atherogenic Index Associated with Poor Prognosis in Hospitalized Patients with Acute Myocardial Infarction</dc:title>
	<dc:creator>Hartopo, Anggoro Budi</dc:creator>
	<dc:creator>Arso, Irsad Andi</dc:creator>
	<dc:creator>Setianto, Budi Yuli</dc:creator>
	<dc:subject xml:lang="en-US">atherogenic lipids</dc:subject>
	<dc:subject xml:lang="en-US">atherogenic index of plasma</dc:subject>
	<dc:subject xml:lang="en-US">major adverse cardiovascular events</dc:subject>
	<dc:subject xml:lang="en-US">mortality</dc:subject>
	<dc:description xml:lang="en-US">Aim: the impact of atherogenic index of plasma (AIP), calculated as logarithmic of triglyceride:HDL ratio (log10.[TG:HDL]), on major adverse cardiovascular events (MACE) during acute myocardial infarction (AMI) has not been fully accepted. This study aims to investigate the role of AIP in predicting major adverse cardiovascular events following AMI during intensive care in the hospital. Methods: this was a prospective cohort study. We enrolled subjects with AMI hospitalized in intensive coronary care unit at Dr. Sardjito General Hospital, Yogyakarta. The AIP was measured in fasting blood within 24 hours of hospital admission. The total cholesterol, LDL, HDL, and triglyceride (TG), were measured and AIP value was determined as log10.[TG:HDL]). Based on AIP value, subjects were allocated into low AIP (&amp;lt;0.24) and high AIP (≥0.24). The outcome of the study was major adverse cardiovascular events during hospitalization, i.e. multipart of all cause mortality, acute heart failure, cardiogenic shock, reinfarction, and rescucitated VT/VF. Results: among 277 subjects, the high AIP group comprised 213 subjects (77%) and low AIP group comprised 64 subjects (33%). During intensive hospitalisation, 66 subjects (24%) developed MACE and 20 subjects (7%) developed fatal outcome (all cause mortality). The incidence of MACE tended to be higher in low AIP group, however its difference was not significant. The incidence of all cause mortality was significantly higher in low AIP group (14%) than in high AIP group (5%). Multivariable analysis showed that low AIP predicted all cause mortality independently with a risk ratio 3.71 (95% CI 1.26 – 10.97, p=0.02). Conclusion: low AIP value (&amp;lt;0.24) is an independent predictor for all cause mortality in patients with acute myocardial infarction undergoing intensive hospitalisation.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2016-09-21</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/147</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 48 No. 2 (2016): Acta Medica Indonesiana; 106-113</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/147/142</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2016 Acta Medica Indonesiana - The Indonesian Journal of Internal Medicine</dc:rights>
</oai_dc:dc>