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Mortality-related Factors in Patients with Malignant Obstructive Jaundice

ACTA MEDICA INDONESIANA · Vol. 48 No. 4 (2017) · pp. 282–288

ISSN
2338-2732, 0125-9326
Published
2017-02-01
Publisher
The Indonesian Society of Internal Medicine
Language
eng

Abstract

Aim: to obtain survival rate and mortality-related factors of malignant obstructive jaundice patients. Methods: all medical records of obstructive jaundice inpatient at Cipto Mangunkusumo Hospital, Jakarta from January 2010 to December 2013 were reviewed retrospectively. The following factors were analyzed in terms of mortality: age, gender, sepsis, hypoalbumin, serum bilirubin level, serum CA 19-9 level, billiary drainage, non-ampulla Vateri carcinoma, and comorbid factors. Results: total 181 out of 402 patients were enrolled in this study with male proportion was 58.6%, and patients aged 50 years or above was 57.5%. Multivariate analysis showed that only sepsis, unsuccessful or no prior biliary drainage and Charlson comorbid score ≥4 were independent predictors of mortality. Patients with significant prognostic factors had median survival 14 days compared with overall median survival 26 days. Score ≥2 identified as the highest prognostic score threshold with sensitivity 68%, specificity 75%, and AUC on ROC curve 0.769. Conclusion: sepsis, unsuccessful or no prior bilirary drainage, and Charlson comorbid score ≥4 are factors significantly associated with shortened survival in malignant obstructive jaundice patients. Prognostic score ≥2 was determined to classify patients into high risk mortality group. Mortality of patients with those significant prognostic factors can be predicted in 76.9%.

Keywords

Collaboration network of the authors

40 authors · 285 co-authorship links · showing the 40 most connected

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Co-authorOrganisationJoint articles
Andri Sanityoso SulaimanAffiliation unknown13
Chyntia Olivia Maurine JasirwanAffiliation unknown11
Kemal Fariz KalistaAffiliation unknown10
Cosmas Rinaldi A LesmanaAffiliation unknown9
Ikhwan RinaldiAffiliation unknown7
Gita ApriliciaAffiliation unknown7
Murdani AbdullahAffiliation unknown6
Andri SanityosoAffiliation unknown6
Lutfie LutfieAffiliation unknown5
Kaka RenaldiAffiliation unknown5
Cosmas Rinaldi Adithya LesmanaAffiliation unknown5
Dadang MakmunAffiliation unknown4
Siti SetiatiAffiliation unknown4
Evy YunihastutiAffiliation unknown4
Hamzah ShatriAffiliation unknown4
Muhammad Begawan BestariAffiliation unknown4
Rino A GaniAffiliation unknown3
Achmad FauziAffiliation unknown3
Hasan MaulahelaAffiliation unknown3
Kuntjoro HarimurtiAffiliation unknown3
Sally Aman NasutionAffiliation unknown3
Cleopas Martin RumendeAffiliation unknown3
Dyah PurnamasariAffiliation unknown3
Fandy GosalAffiliation unknown3
Pringgodigdo NugrohoAffiliation unknown3
Ari F SyamAffiliation unknown2
Randy AdiwinataAffiliation unknown2
Rabbinu Rangga PribadiAffiliation unknown2
Saskia Aziza NursyirwanAffiliation unknown2
Dicky Levenus TahaparyAffiliation unknown2
Esthika DewiastyAffiliation unknown2
Leonard NainggolanAffiliation unknown2
Purwita Wijaya LaksmiAffiliation unknown2
Muhadi MuhadiAffiliation unknown2
Eka GinanjarAffiliation unknown2
Noto DwimartutieAffiliation unknown2

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Mortality-related Factors in Patients with Malignant Obstructive Jaundice</dc:title>
	<dc:creator>Kurniawan, Juferdy</dc:creator>
	<dc:creator>Hasan, Irsan</dc:creator>
	<dc:creator>Gani, Rino Alvani</dc:creator>
	<dc:creator>Simadibrata, Marcellus</dc:creator>
	<dc:subject xml:lang="en-US">malignant obstructive jaundice</dc:subject>
	<dc:subject xml:lang="en-US">survival</dc:subject>
	<dc:subject xml:lang="en-US">mortality</dc:subject>
	<dc:subject xml:lang="en-US">prognostic factors</dc:subject>
	<dc:subject xml:lang="en-US">prognostic score</dc:subject>
	<dc:description xml:lang="en-US">Aim: to obtain survival rate and mortality-related factors of malignant obstructive jaundice patients. Methods: all medical records of obstructive jaundice inpatient at Cipto Mangunkusumo Hospital, Jakarta from January 2010 to December 2013 were reviewed retrospectively. The following factors were analyzed in terms of mortality: age, gender, sepsis, hypoalbumin, serum bilirubin level, serum CA 19-9 level, billiary drainage, non-ampulla Vateri carcinoma, and comorbid factors. Results: total 181 out of 402 patients were enrolled in this study with male proportion was 58.6%, and patients aged 50 years or above was 57.5%. Multivariate analysis showed that only sepsis, unsuccessful or no prior biliary drainage and Charlson comorbid score ≥4 were independent predictors of mortality. Patients with significant prognostic factors had median survival 14 days compared with overall median survival 26 days. Score ≥2 identified as the highest prognostic score threshold with sensitivity 68%, specificity 75%, and AUC on ROC curve 0.769. Conclusion: sepsis, unsuccessful or no prior bilirary drainage, and Charlson comorbid score ≥4 are factors significantly associated with shortened survival in malignant obstructive jaundice patients. Prognostic score  ≥2 was determined to classify patients into high risk mortality group. Mortality of patients with those significant prognostic factors can be predicted in 76.9%.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2017-02-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/175</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 48 No. 4 (2016): Acta Medica Indonesiana; 282-288</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/175/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2017 Acta Medica Indonesiana - The Indonesian Journal of Internal Medicine</dc:rights>
</oai_dc:dc>