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Autologous Bone Marrow Transplant in Multiple Myeloma Patient With Bone Marrow Hematopoietic Stem Cell

ACTA MEDICA INDONESIANA · Vol. 52 No. 4 (2020)

ISSN
2338-2732, 0125-9326
Published
2020-12-28
Publisher
The Indonesian Society of Internal Medicine
Language
eng

Abstract

Multiple myeloma (MM) is a malignancy with multiple complications such as recurrent bacterial infections, anemia, osteolytic lesions, bone marrow failure and decreased kidney function. In developed transplant center, the bone marrow transplant procedure is performed by the source of peripheral blood stem cells. Apheresis machine which is not always available in all Haematology and Oncology Centre in Indonesia, is required for harvesting stem cell from PBSC (peripheral blood stem cell). There are only a few reports on marrow-derived stem cells transplant from BM with a 24-hour storage in multiple myeloma cases. We report two cases with non-secretory myeloma stage III and IgG myeloma stage II (International Staging System). Both patients were treated with induction regimens CyBord until a complete remission. Once remission was achieved, an autologous bone marrow transplant procedures were performed. The source of haematopietic stem cells (HSCs) were harvested from bone marrow and stored for 24 hours at a temperature of 4◦ C. The complications were neutropenia, anemia, thrombocytopenia, mucositis, diarrhea, hair loss, and skin darkness. The HSCs grew well on day 12 and 23. After treatment in the isolation room, the patient’s condition improved and the patients were discharged.

Keywords

Collaboration network of the authors

40 authors · 147 co-authorship links · showing the 40 most connected

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  • Kementerian Kesehatan Republik Indonesia
  • Affiliation unknown
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  • Same organisation
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Co-authorOrganisationJoint articles
Sarjadi SarjadiAffiliation unknown2
Nuzirwan AcangAffiliation unknown1
Lugyanti SukrismanAffiliation unknown1
Karmel L TambunanAffiliation unknown1
Trinugroho Heri FadjariAffiliation unknown1
Johan KurniandaAffiliation unknown1
Shinta O. WardhaniAffiliation unknown1
Noorwati SoetandyoAffiliation unknown1
Ni Made R.A. RenaAffiliation unknown1
Andi F. BenyaminAffiliation unknown1
Muhammad Darwin PrenggonoAffiliation unknown1
Dairon GatotAffiliation unknown1
Jacub PandelakiAffiliation unknown1
Budi SetiawanAffiliation unknown1
Eko Adhi PangarsaAffiliation unknown1
Damai SantosaAffiliation unknown1
Ridho M NaibahoAffiliation unknown1
Rahajuningsih Dharma SetiabudyAffiliation unknown1
Suharyo HadisaputroAffiliation unknown1
Ignatius RiwantoAffiliation unknown1
Ai Sri KosnayaniAffiliation unknown1
Rebriarina HapsariAffiliation unknown1
Dionisius DenisAffiliation unknown1
R. Tedjo SasmonoAffiliation unknown1
Benediktus YohanAffiliation unknown1
Sotianingsih HaryantoAffiliation unknown1
Jonathan Alvin Nugraha HalimAffiliation unknown1
Stefanie Natalia HalimAffiliation unknown1
Neni SusilaningsihAffiliation unknown1
Sri SusilowatiAffiliation unknown1
Maria Dyah KurniasariAffiliation unknown1
Hussein GasemAffiliation unknown1
Novita NirmalasariAffiliation unknown1
Mardiyono MardiyonoKementerian Kesehatan Republik Indonesia1
Thohar ArifinAffiliation unknown1
Agus SantosoAffiliation unknown1
Vera FitrianaAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Autologous Bone Marrow Transplant in Multiple Myeloma Patient With Bone Marrow Hematopoietic Stem Cell</dc:title>
	<dc:creator>Santosa, D</dc:creator>
	<dc:creator>Suharti, Catharina</dc:creator>
	<dc:creator>Dharmana, Edi</dc:creator>
	<dc:subject xml:lang="en-US">myeloma</dc:subject>
	<dc:subject xml:lang="en-US">haematopoetic stem cells</dc:subject>
	<dc:subject xml:lang="en-US">bone marrow</dc:subject>
	<dc:subject xml:lang="en-US">autologous transplants</dc:subject>
	<dc:description xml:lang="en-US">Multiple myeloma (MM) is a malignancy with multiple complications such as recurrent bacterial infections, anemia, osteolytic lesions, bone marrow failure and decreased kidney function. In developed transplant center, the bone marrow transplant procedure is performed by the source of peripheral blood stem cells. Apheresis machine which is not always available in all Haematology and Oncology Centre in Indonesia, is required for harvesting stem cell from PBSC (peripheral blood stem cell). There are only a few reports on marrow-derived stem cells transplant from BM with a 24-hour storage in multiple myeloma cases. We report two cases with non-secretory myeloma stage III and IgG myeloma stage II (International Staging System). Both patients were treated with induction regimens CyBord until a complete remission. Once remission was achieved, an autologous bone marrow transplant procedures were performed. The source of haematopietic stem cells (HSCs) were harvested from bone marrow and stored for 24 hours at a temperature of 4◦ C. The complications were neutropenia, anemia, thrombocytopenia, mucositis, diarrhea, hair loss, and skin darkness. The HSCs grew well on day 12 and 23. After treatment in the isolation room, the patient’s condition improved and the patients were discharged.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2020-12-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/512</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 52 No. 4 (2020): Acta Medica Indonesiana; 383</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/512/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>