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Efficacy of Curcumin as Adjuvant Therapy to Induce or Maintain Remission in Ulcerative Colitis Patients: an Evidence-based Clinical Review

ACTA MEDICA INDONESIANA · Vol. 49 No. 4 (2018)

ISSN
2338-2732, 0125-9326
Published
2018-01-19
Publisher
The Indonesian Society of Internal Medicine
Language
eng

Abstract

Background: treatment guidelines for ulcerative colitis (UC) not yet established. Currently, mesalazine, corticosteroids, and immunomodulators are treatment options for UC. However, they are known to have unpleaseant side effects such as nausea, vomiting, headaches, hepatitis, and male infertility. Curcumin is found in Turmeric plants (Curcuma longa L.), which possesses both anti-inflammatory and antioxidant properties. This study aimed to determine whether curcumin as adjuvant therapy can induce or maintain remission in UC patients. Methods: structured search in three database (Cochrane, PubMed, Proquest) using “Curcumin”, “remission” and “Ulcerative Colitis” as keywords. Inclusion criteria is randomized controlled trials (RCTs), meta-analysis, or systematic review using curcumin as adjuvant therapy in adult UC patients.Results: we found 49 articles. After exclusion, three RCTs were reviewed; two examined curcumin efficacy to induce remission and one for remision maintenance in UC. Curcumin was significantly more effective than placebo in all RCTs. The efficacy of curcumin could be explained by its anti-inflammatory properties, which inhibit NF-kB pathway. Regulation of oxidant/anti-oxidant balance can modify the release of cytokines. However, methods varied between RCTs. Therefore, they cannot be compared objectively. Futhermore, the sample size were small (n= 50, 45, 89) therefore the statistical power was not enough to generate representative results in all UC patients.Conclusion: Available evidence showed that curcumin has the potential to induce and maintain remission in UC patients with no serious side effects. However, further studies with larger sample size are needed to recommend it as adjuvant therapy of ulcerative colitis.

Keywords

Collaboration network of the authors

40 authors · 192 co-authorship links · showing the 40 most connected

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Co-authorOrganisationJoint articles
Murdani AbdullahAffiliation unknown4
Dadang MakmunAffiliation unknown3
Kaka RenaldiAffiliation unknown3
Juferdy KurniawanAffiliation unknown2
Ari F SyamAffiliation unknown2
Randy AdiwinataAffiliation unknown2
Achmad FauziAffiliation unknown2
Hasan MaulahelaAffiliation unknown2
Rabbinu Rangga PribadiAffiliation unknown2
Saskia Aziza NursyirwanAffiliation unknown2
Irsan HasanAffiliation unknown1
Rino Alvani GaniAffiliation unknown1
Dewi FriskaAffiliation unknown1
Deriyan Sukma WidjajaAffiliation unknown1
Liana SrisawitriAffiliation unknown1
Siti SetiatiAffiliation unknown1
Laura A SiahaanAffiliation unknown1
Dyah PurnamasariAffiliation unknown1
Laras BudiyaniAffiliation unknown1
Amanda P UtariAffiliation unknown1
Ari Fahrial SyamAffiliation unknown1
Muhammad Begawan BestariAffiliation unknown1
Roy SutiknoAffiliation unknown1
Kresna Dharma SuryanaAffiliation unknown1
Andrea LivinaAffiliation unknown1
Bradley Jimmy WalelengAffiliation unknown1
Fandy GosalAffiliation unknown1
Luciana RottyAffiliation unknown1
Jeanne WinartaAffiliation unknown1
Andrew WalelengAffiliation unknown1
Harlinda HaroenAffiliation unknown1
Linda RottyAffiliation unknown1
Cecilia hendrattaAffiliation unknown1
Pearla LasutAffiliation unknown1
Angelica AbigaelAffiliation unknown1
Lidya TanjayaAffiliation unknown1
Andri Sanityoso SulaimanAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Efficacy of Curcumin as Adjuvant Therapy to Induce or Maintain Remission in Ulcerative Colitis Patients:  an Evidence-based Clinical Review</dc:title>
	<dc:creator>Simadibrata, Marcellus</dc:creator>
	<dc:creator>Halimkesuma, Christopher Christian</dc:creator>
	<dc:creator>Suwita, Benedicta Mutiara</dc:creator>
	<dc:subject xml:lang="en-US">curcumin</dc:subject>
	<dc:subject xml:lang="en-US">remission</dc:subject>
	<dc:subject xml:lang="en-US">maintenance</dc:subject>
	<dc:subject xml:lang="en-US">ulcerative colitis</dc:subject>
	<dc:subject xml:lang="en-US">gastroenterology</dc:subject>
	<dc:description xml:lang="en-US">Background: treatment guidelines for ulcerative colitis (UC) not yet established. Currently, mesalazine, corticosteroids, and immunomodulators are treatment options for UC. However, they are known to have unpleaseant side effects such as nausea, vomiting, headaches, hepatitis, and male infertility. Curcumin is found in Turmeric plants (Curcuma longa L.), which possesses both anti-inflammatory and antioxidant properties. This study aimed to determine whether curcumin as adjuvant therapy can induce or maintain remission in UC patients. Methods: structured search in three database (Cochrane, PubMed, Proquest) using “Curcumin”, “remission” and “Ulcerative Colitis” as keywords. Inclusion criteria is randomized controlled trials (RCTs), meta-analysis, or systematic review using curcumin as adjuvant therapy in adult UC patients.Results: we found 49 articles. After exclusion, three RCTs were reviewed; two examined curcumin efficacy to induce remission and one for remision maintenance in UC. Curcumin was significantly more effective than placebo in all RCTs. The efficacy of curcumin could be explained by its anti-inflammatory properties, which inhibit NF-kB pathway. Regulation of oxidant/anti-oxidant balance can modify the release of cytokines. However, methods varied between RCTs. Therefore, they cannot be compared objectively. Futhermore, the sample size were small (n= 50, 45, 89) therefore the statistical power was not enough to generate representative results in all UC patients.Conclusion: Available evidence showed that curcumin has the potential to induce and maintain remission in UC patients with no serious side effects. However, further studies with larger sample size are needed to recommend it as adjuvant therapy of ulcerative colitis.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2018-01-19</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/520</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 49 No. 4 (2017): Acta Medica Indonesiana; 363</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/520/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>