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The Association of b2-Microglobulin and Fibroblast Growth Factor 23 with Major Adverse Cardiac Event in Acute Coronary Syndrome Patients with Chronic Kidney Disease

ACTA MEDICA INDONESIANA · Vol. 53 No. 1 (2021)

ISSN
2338-2732, 0125-9326
Published
2021-03-31
Publisher
The Indonesian Society of Internal Medicine
Language
eng

Abstract

Background: chronic kidney disease (CKD) increases the severity and risk of mortality in acute coronary syndrome (ACS) patients. The role of β2-M as a filtration and inflammation marker and FGF23 as a CKD-MBD process marker might be significant in the pathophysiology in ACS with CKD patients. This study aims to determine the association of β2-M and FGF23 with major adverse cardiac event (MACE) in ACS patients with CKD. Methods: we used cross sectional and retrospective cohort analysis for MACE. We collected ACS patients with CKD consecutively from January until October 2018 at Dr. Cipto Mangunkusumo General Hospital. Data were analyzed using logistic regression and Cox’s Proportional Hazard Regression. Results: a total of 117 patients were selected according to the study criteria. In bivariate analysis, β2-M, FGF23, and stage of CKD had significant association with MACE (p = 0.014, p = 0.026, p = 0.014, respectively). In multivariate analysis, β2-M - but not FGF 23- was significantly associated with MACE (adjusted HR 2.16; CI95% 1.15–4.05; p = 0.017). Conclusion: β2-M was significantly associated with MACE, while FGF23 was not so. This finding supports the role of inflammation in cardiovascular outcomes in ACS with CKD patient through acute on chronic effect.

Keywords

Collaboration network of the authors

40 authors · 292 co-authorship links · showing the 40 most connected

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  • University of Indonesia
  • Affiliation unknown
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  • Same organisation
  • Affiliation unknown
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Co-authorOrganisationJoint articles
Siti SetiatiAffiliation unknown21
Simon SalimAffiliation unknown11
Rudi PutrantoAffiliation unknown10
Hamzah ShatriAffiliation unknown10
Arif MansjoerAffiliation unknown10
Sally Aman NasutionAffiliation unknown8
Suhendro SuwartoAffiliation unknown7
Noto DwimartutieAffiliation unknown6
Evy YunihastutiAffiliation unknown6
Andhika RachmanAffiliation unknown6
Imam SubektiAffiliation unknown6
Birry KarimAffiliation unknown5
Em YunirUniversity of Indonesia5
Pringgodigdo NugrohoAffiliation unknown5
Annisa Puspitasari NachrowiAffiliation unknown5
Roza MulyanaAffiliation unknown4
Eka Dian SafitriAffiliation unknown4
Rahmi IstantiAffiliation unknown4
Ika P WijayaAffiliation unknown4
Cosphiadi IrawanAffiliation unknown4
Iris RengganisAffiliation unknown4
Lies Dina LiastutiAffiliation unknown4
Yulianto YuliantoAffiliation unknown3
Respati W RanakusumaAffiliation unknown3
Siti Rizny F SaldiAffiliation unknown3
Jessica MarsigitAffiliation unknown3
Sri SunartiAffiliation unknown3
Fatichati BudiningsihAffiliation unknown3
Lazuardhi DwipaAffiliation unknown3
Cleopas Martin RumendeAffiliation unknown3
Ceva Wicaksono PitoyoAffiliation unknown3
Aulia RizkaAffiliation unknown3
Adityo SusiloAffiliation unknown3

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">The Association of b2-Microglobulin and Fibroblast Growth Factor 23 with Major Adverse Cardiac Event in Acute Coronary Syndrome Patients with Chronic Kidney Disease</dc:title>
	<dc:creator>Ginanjar, Eka</dc:creator>
	<dc:creator>Alwi, Idrus</dc:creator>
	<dc:creator>Lydia, Aida</dc:creator>
	<dc:creator>Immanuel, Suzanna</dc:creator>
	<dc:creator>Yamin, Muhammad</dc:creator>
	<dc:creator>Indrajaya, Taufik</dc:creator>
	<dc:creator>Harimurti, Kuntjoro</dc:creator>
	<dc:subject xml:lang="en-US">Beta2-Microglobulin</dc:subject>
	<dc:subject xml:lang="en-US">Fibrioblast Growth Factor 23</dc:subject>
	<dc:subject xml:lang="en-US">Acute Coronary Syndrome</dc:subject>
	<dc:subject xml:lang="en-US">Major Adverse Cardiac Event</dc:subject>
	<dc:subject xml:lang="en-US">Internal Medicine</dc:subject>
	<dc:subject xml:lang="en-US">Cardiology</dc:subject>
	<dc:description xml:lang="en-US">Background: chronic kidney disease (CKD) increases the severity and risk of mortality in acute coronary syndrome (ACS) patients. The role of β2-M as a filtration and inflammation marker and FGF23 as a CKD-MBD process marker might be significant in the pathophysiology in ACS with CKD patients. This study aims to determine the association of β2-M and FGF23 with major adverse cardiac event (MACE) in ACS patients with CKD. Methods: we used cross sectional and retrospective cohort analysis for MACE. We collected ACS patients with CKD consecutively from January until October 2018 at Dr. Cipto Mangunkusumo General Hospital. Data were analyzed using logistic regression and Cox’s Proportional Hazard Regression. Results: a total of 117 patients were selected according to the study criteria. In bivariate analysis, β2-M, FGF23, and stage of CKD had significant association with MACE (p = 0.014, p = 0.026, p = 0.014, respectively). In multivariate analysis, β2-M - but not FGF 23- was significantly associated with MACE (adjusted HR 2.16; CI95% 1.15–4.05; p = 0.017). Conclusion: β2-M was significantly associated with MACE, while FGF23 was not so. This finding supports the role of inflammation in cardiovascular outcomes in ACS with CKD patient through acute on chronic effect.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2021-03-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Cross sectional and Prospective Cohort</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/999</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 53 No. 1 (2021): Acta Medica Indonesiana; 5</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/999/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2021 Acta Medica Indonesiana</dc:rights>
</oai_dc:dc>