Melola Discovery

← Melola Discovery

Journal SINTA 1

Revisiting the Overlooked Infection: Rickettsioses

ACTA MEDICA INDONESIANA · Vol. 54 No. 4 (2023)

ISSN
2338-2732, 0125-9326
Published
2023-01-10
Publisher
The Indonesian Society of Internal Medicine
Language
eng

Abstract

The prevalence of human Rickettsioses cases in Indonesia is unknown and could probably be underestimated. The high prevalence of seropositive Rickettsia sp. was reported in small mammals (as vectors) and humans. In Indonesia, a recent study in patients with acute fever revealed that the prevalence of Rickettsioses is 10%. Many cases of Rickettsioses were often misdiagnosed with dengue fever, enteric fever, or leptospirosis due to their overlapping clinical manifestation. The limitation of point of care testing in Indonesia hindered the adequacy of diagnosis confirmation. Appropriate empirical or definitive treatment with macrolide, mainly doxycycline, is preferable compared to other broad-spectrum antibiotics, such as cephalosporin or quinolones. Moreover, when left untreated, Rickettsioses may deteriorate progressively to fatal outcomes, such as meningitis, sepsis, and even death. The awareness of health care practitioners, the availability of confirmatory rapid diagnostic tests and adequate treatment choices are important in eradicating this disease.

Keywords

Collaboration network of the authors

40 authors · 154 co-authorship links · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Cleopas Martin RumendeAffiliation unknown11
Ikhwan RinaldiAffiliation unknown9
Randy AdiwinataAffiliation unknown7
Hamzah ShatriAffiliation unknown6
Erni J NelwanAffiliation unknown4
Suryo Anggoro Kusumo WibowoAffiliation unknown4
Rahajeng N TunjungputriAffiliation unknown3
Adeline Intan PasaribuAffiliation unknown3
Djoko WidodoAffiliation unknown3
Irsan HasanAffiliation unknown3
Murdani AbdullahAffiliation unknown3
Suhendro SuhendroAffiliation unknown2
Mulya Rahma KaryantiAffiliation unknown2
Noto DwimartutieAffiliation unknown2
Adityo SusiloAffiliation unknown2
Yulia Rosa SaharmanAffiliation unknown2
Cleopas M RumendeAffiliation unknown1
Eppy EppyAffiliation unknown1
Evi IndrasantiAffiliation unknown1
Farida NurchaidaAffiliation unknown1
Rustadi SosrosumihardjoAffiliation unknown1
Andi KristantoAffiliation unknown1
Silvia SumintoAffiliation unknown1
Benny N KurniawanAffiliation unknown1
Finna ChristiantyAffiliation unknown1
Suhendro SuwartoAffiliation unknown1
Esthika DewiastyAffiliation unknown1
Candra WigunaAffiliation unknown1
Iqbal Zein AssyidiqieAffiliation unknown1
Hindra Irawan SatariAffiliation unknown1
Sri Rezeki HadinegoroAffiliation unknown1
Narottama TunjungAffiliation unknown1
Helio GuterresAffiliation unknown1
Ralalicia LimatoAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Revisiting the Overlooked Infection: Rickettsioses</dc:title>
	<dc:creator>Lie, Khie Chen</dc:creator>
	<dc:creator>Nelwan, Erni Juwita</dc:creator>
	<dc:creator>Pasaribu, Adeline</dc:creator>
	<dc:creator>Shakinah, Sharifah</dc:creator>
	<dc:creator>Sinto, Robert</dc:creator>
	<dc:creator>Nainggolan, Leonard</dc:creator>
	<dc:subject xml:lang="en-US">internal medicine</dc:subject>
	<dc:subject xml:lang="en-US">tropical disease</dc:subject>
	<dc:subject xml:lang="en-US">infection</dc:subject>
	<dc:subject xml:lang="en-US">rickettsioses</dc:subject>
	<dc:subject xml:lang="en-US">tropical infectious disease</dc:subject>
	<dc:description xml:lang="en-US">The prevalence of human Rickettsioses cases in Indonesia is unknown and could probably be underestimated. The high prevalence of seropositive Rickettsia sp. was reported in small mammals (as vectors) and humans. In Indonesia, a recent study in patients with acute fever revealed that the prevalence of Rickettsioses is 10%. Many cases of Rickettsioses were often misdiagnosed with dengue fever, enteric fever, or leptospirosis due to their overlapping clinical manifestation. The limitation of point of care testing in Indonesia hindered the adequacy of diagnosis confirmation. Appropriate empirical or definitive treatment with macrolide, mainly doxycycline, is preferable compared to other broad-spectrum antibiotics, such as cephalosporin or quinolones. Moreover, when left untreated, Rickettsioses may deteriorate progressively to fatal outcomes, such as meningitis, sepsis, and even death. The awareness of health care practitioners, the availability of confirmatory rapid diagnostic tests and adequate treatment choices are important in eradicating this disease.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2023-01-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2068</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 54 No. 4 (2022): Acta Medica Indonesiana; 647</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2068/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Khie Chen Lie, Erni Juwita Nelwan, Adeline Pasaribu, Sharifah Shakinah, Robert Sinto, Leonard Nainggolan</dc:rights>
</oai_dc:dc>