Journal SINTA 1
Polymorphisms of SLCO1B1 Gene in Sundanese Ethnic Population of Tuberculosis Patients in Indonesia
ACTA MEDICA INDONESIANA · Vol. 54 No. 4 (2023)
- ISSN
- 2338-2732, 0125-9326
- Published
- 2023-01-10
- Publisher
- The Indonesian Society of Internal Medicine
- Language
- eng
Abstract
Background: The blood level of rifampicin, one of the tuberculosis (TB) drugs, depends on the organic anion transporting polypeptide 1B1 (OATP1B1) in hepatocytes. This protein is encoded by the solute carrier organic anion 1B1 (SLCO1B1) gene. Its genetic variation has been reported to have an impact on clinical outcomes and drug efficacy. However, the polymorphism in the SLCO1B1 gene has not been examined in Indonesia yet. We aimed to identify the frequency of polymorphism in SLCO1B1 gene among pulmonary TB patients in Bandung, Indonesia. Methods: Cross-sectional study was conducted in West Java. 145 pulmonary TB patients who were treated with first-line drugs treatment (including rifampicin 450 mg daily) were analyzed for polymorphism in SLCO1B1 gene. Patients aged between 18–64 years old and mainly came from Sundanese ethnic group (92.4%). Genetic variants were detected using Polymerase Chain Reaction (PCR) and Sanger sequencing. Results: Polymorphism of c.463C>A(rs11045819) was not identified, while heterozygous and homozygous polymorphism of c.85-7793C>T(rs4149032) were identified in 74 (51.0%) and 56 (38.6%) patients, respectively. The minor allele frequency (MAF) of T (mutant) allele of c.85-7793C>T(rs4149032) was 64.13% (186/209), higher than in the general population, which the MAF of rs4149032 is 53.6% based on 1000 genome database. Conclusion: This study highlights the presence of different allele frequencies of polymorphisms within the population, which might affect treatment outcomes.
Keywords
Collaboration network of the authors
40 authors · 140 co-authorship links · showing the 40 most connected
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- Tadulako University
- Affiliation unknown
- Different organisations
- Same organisation
- Affiliation unknown
- Thicker line = more joint articles · bigger circle = more articles
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| Co-author | Organisation | Joint articles |
|---|---|---|
| Hikmat Permana | Affiliation unknown | 3 |
| Edhyana Sahiratmadja | Affiliation unknown | 2 |
| Ida Parwati | Affiliation unknown | 2 |
| Yovita Hartantri | Affiliation unknown | 2 |
| Zulkarnain Dahlan | Affiliation unknown | 1 |
| Cissy B Kartasasmita | Affiliation unknown | 1 |
| Guntur Darmawan | Affiliation unknown | 1 |
| Trinugroho Heri Fadjari | Affiliation unknown | 1 |
| R.N. Yasmin Kusumawardhani | Affiliation unknown | 1 |
| Rianita Juniati | Affiliation unknown | 1 |
| Rudi Wisaksana | Affiliation unknown | 1 |
| Arto Y Soeroto | Affiliation unknown | 1 |
| Bachti Alisjabana | Affiliation unknown | 1 |
| Heda M Nataprawira | Affiliation unknown | 1 |
| Jipi E Perkusi | Affiliation unknown | 1 |
| Ferdy Ferdian | Affiliation unknown | 1 |
| Undang Rehimat | Affiliation unknown | 1 |
| Hendarsyah Suryadinata | Affiliation unknown | 1 |
| Dewi Kartika | Affiliation unknown | 1 |
| Aluisha Saboe | Affiliation unknown | 1 |
| Nanny NM Soetedjo | Affiliation unknown | 1 |
| Indra Wijaya | Affiliation unknown | 1 |
| Laniyati Hamijoyo | Affiliation unknown | 1 |
| Dimmy Prasetya | Affiliation unknown | 1 |
| M Lucky Nurdiansyah Prameswara | Affiliation unknown | 1 |
| Andri Reza Rahmadi | Affiliation unknown | 1 |
| Ahmad Rizal | Affiliation unknown | 1 |
| Juni Wijayanti Puspita | Tadulako University | 1 |
| Suryani Gunadharma | Affiliation unknown | 1 |
| Tri Hanggono Achmad | Affiliation unknown | 1 |
| See Siew Ju | Affiliation unknown | 1 |
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