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CXCL8, MMP1, MMP2, and FN1 Gene Expression and Tumor Extension in Nasopharyngeal Cancer Patients: A Cross-sectional Study

ACTA MEDICA INDONESIANA · Vol. 55 No. 3 (2023)

ISSN
2338-2732, 0125-9326
Published
2023-11-01
Publisher
The Indonesian Society of Internal Medicine
Language
eng

Abstract

Background: There are correlations between tumor staging, lymph node involvement, and patient survival in Nasopharyngeal cancer (NPC) which is one of the most common types of cancer in Indonesia. The inflammation process plays a role in tumor progression over the long term and this marked by increased proinflammatory cytokine and gene overexpression. This study aims to identify differentially expressed genes (DEGs) in NPC using T and N staging. Methods: This is a cross-sectional study of NPC patients in Cipto Mangunkusumo, Jakarta, between 2018 and 2022. DEGs were identified based on the amount of mRNA detected on paraffin blocks with a 1.5- to -1.5-fold change and an adjusted p-value of <0.05. Results: We included 48 subjects. The mean age of subjects was 47.75 (10.48) years, and most were male (77.1%). Non-keratinized squamous cell carcinoma was the most common histopathology type. Differences in the tumor size of the T4 and non-T4 in metastatic (33.3%) group when compared to the non-metastatic (37.5%) group were insignificant (p = 0.763). The proportion of N3 subjects in the metastatic vs non-metastatic group was different significantly (83.3% vs. 50%, p = 0.030). Gene expression analysis showed that C-X-C motif ligand 8 (CXCL8), matrix metalloproteinase-1 (MMP1), matrix metalloproteinase-1 (MMP2), and fibronectin-1 (FN1) genes of the T4 and non-T4 group to be different significantly. Conclusion: There was significant finding in the N3 subjects of the metastatic and non-metastatic groups. The DEGs of CXCL8, MMP1, MMP2, and FN1 were statistically significant in the T4 when compared to the non-T4 group.

Keywords

Collaboration network of the authors

40 authors · 140 co-authorship links · showing the 40 most connected

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  • University of Indonesia
  • Universitas Halu Oleo
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
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Co-authorOrganisationJoint articles
Em YunirUniversity of Indonesia4
Hamzah ShatriAffiliation unknown3
Rudi PutrantoAffiliation unknown3
Djumhana AtmakusumahAffiliation unknown3
Abdulmuthalib AbdulmuthalibAffiliation unknown3
Tri Juli Edi TariganUniversity of Indonesia3
Imam SubektiAffiliation unknown3
Sabarudin AhmadAffiliation unknown2
Aru W SudoyoAffiliation unknown2
Idrus AlwiAffiliation unknown2
Mizanul AdliAffiliation unknown2
Dina ElitaAffiliation unknown2
Ratih Arianita AgungAffiliation unknown2
Czeresna Heriawan SoejonoAffiliation unknown2
Andhika RachmanAffiliation unknown2
Aria KekalihAffiliation unknown2
Aulia RizkaAffiliation unknown2
La Ode Muhammad Harjoni KilowasidAffiliation unknown1
Nurhaida NurhaidaAffiliation unknown1
Samsu AlamAffiliation unknown1
Sarawa SarawaAffiliation unknown1
Dodi Priyatmo SilondaeUniversitas Halu Oleo1
Sudarmi Suud BinasarAffiliation unknown1
SupriyonoAffiliation unknown1
Dadi Mulyadi NugrahaAffiliation unknown1
Judhiastuty FebruhartantyAffiliation unknown1
Fitya Safira BirahmatikaAffiliation unknown1
Khalida FauziaAffiliation unknown1
Indriya Laras PramesthiAffiliation unknown1
Helda KhusunAffiliation unknown1
Hera NurlitaAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">CXCL8, MMP1, MMP2, and FN1 Gene Expression and Tumor Extension in Nasopharyngeal Cancer Patients:  A Cross-sectional Study</dc:title>
	<dc:creator>Cahyanur, Rahmat</dc:creator>
	<dc:creator>Irawan, Cosphiadi</dc:creator>
	<dc:creator>Lisnawati, Lisnawati</dc:creator>
	<dc:creator>Adham, Marlinda</dc:creator>
	<dc:creator>Kamal, Achmad Fauzi</dc:creator>
	<dc:creator>Utomo, Ahmad R. Handoyo</dc:creator>
	<dc:creator>Hardianti, Mardiah Suci</dc:creator>
	<dc:creator>Mansyur, Muchtaruddin</dc:creator>
	<dc:creator>Salamah, Thariqah</dc:creator>
	<dc:subject xml:lang="en-US">nasopharyngeal cancer</dc:subject>
	<dc:subject xml:lang="en-US">C-X-C Ligand 8</dc:subject>
	<dc:subject xml:lang="en-US">matrix metalloproteinase-1</dc:subject>
	<dc:subject xml:lang="en-US">matrix metalloproteinase-2</dc:subject>
	<dc:subject xml:lang="en-US">fibronectin-1</dc:subject>
	<dc:description xml:lang="en-US">Background: There are correlations between tumor staging, lymph node involvement, and patient survival in Nasopharyngeal cancer (NPC) which is one of the most common types of cancer in Indonesia.  The inflammation process plays a role in tumor progression over the long term and this marked by increased proinflammatory cytokine and gene overexpression. This study aims to identify differentially expressed genes (DEGs) in NPC using T and N staging. Methods: This is a cross-sectional study of NPC patients in Cipto Mangunkusumo, Jakarta, between 2018 and 2022. DEGs were identified based on the amount of mRNA detected on paraffin blocks with a 1.5- to -1.5-fold change and an adjusted p-value of &amp;lt;0.05. Results: We included 48 subjects. The mean age of subjects was 47.75 (10.48) years, and most were male (77.1%). Non-keratinized squamous cell carcinoma was the most common histopathology type. Differences in the tumor size of the T4 and non-T4 in metastatic (33.3%) group when compared to the non-metastatic (37.5%) group were insignificant (p = 0.763). The proportion of N3 subjects in the metastatic vs non-metastatic group was different significantly (83.3% vs. 50%, p = 0.030). Gene expression analysis showed that C-X-C motif ligand 8 (CXCL8), matrix metalloproteinase-1 (MMP1), matrix metalloproteinase-1 (MMP2), and fibronectin-1 (FN1) genes of the T4 and non-T4 group to be different significantly. Conclusion: There was significant finding in the N3 subjects of the metastatic and non-metastatic groups. The DEGs of CXCL8, MMP1, MMP2, and FN1 were statistically significant in the T4 when compared to the non-T4 group.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2023-11-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">cross sectional</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2442</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 55 No. 3 (2023): Acta Medica Indonesiana; 261</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2442/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Rahmat Cahyanur</dc:rights>
</oai_dc:dc>