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Comparison of CISNE and MASCC Score in Predicting Complications on Post Chemotherapy Febrile Neutropenia

ACTA MEDICA INDONESIANA · Vol. 56 No. 3 (2024)

ISSN
2338-2732, 0125-9326
Published
2024-10-25
Publisher
The Indonesian Society of Internal Medicine
Language
eng

Abstract

Background: Febrile neutropenia (FN) is an oncologic emergency which commonly occurrs in patients who undergo chemotherapy, with a mortality rate of 12.5%. Risk stratification in FN plays an important role in increasing the accuracy of therapy. This study aims to compare the performance between CISNE score and MASCC score in predicting complications on post-chemotherapy FN in solid and hematologic malignancy. Methods: This is a retrospective cohort study on FN patients undergoing inpatient treatment at Cipto Mangunkusumo Hospital between July 2015 and December 2019. Basic demographic and clinical data were collected from medical records. Subjects were grouped based on the CISNE and MASCC score, and complications during hospitalization were recorded. Predictive performance of each score was analyzed and compared using area of under curve. Results: CISNE score showed a better performance both in solid malignancy with AUC of CISNE score (0.80 CI 95% 0.73-0.88, p = 0.00) compared to AUC of MASCC score (0.68; 95% CI 0.59 – 0,78, p = 0.00) and in hematologic malignancy with AUC of CISNE score (0.85; 95% CI 0.77 - 0.93, p = 0.00) and AUC MASCC score (0.65; 95% CI 0.54 - 0.76, p = 0.007). Conclusion: CISNE score showed a better performance compared to MASCC score in predicting in-hospital complication in both solid and hematologic malignancy with cut-off point of 2.

Keywords

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40 authors · 160 co-authorship links · showing the 40 most connected

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Co-authorOrganisationJoint articles
Leonard NainggolanAffiliation unknown25
Adeline PasaribuAffiliation unknown15
Cleopas Martin RumendeAffiliation unknown9
Ikhwan RinaldiAffiliation unknown8
Randy AdiwinataAffiliation unknown6
Hamzah ShatriAffiliation unknown4
Erni J NelwanAffiliation unknown3
Adeline Intan PasaribuAffiliation unknown3
Suryo Anggoro Kusumo WibowoAffiliation unknown3
Djoko WidodoAffiliation unknown3
Mulya Rahma KaryantiAffiliation unknown2
Rahajeng N TunjungputriAffiliation unknown2
Noto DwimartutieAffiliation unknown2
Samuel Theodorus SutantoAffiliation unknown2
Murdani AbdullahAffiliation unknown2
Irsan HasanAffiliation unknown2
Yulia Rosa SaharmanAffiliation unknown2
Evi IndrasantiAffiliation unknown1
Farida NurchaidaAffiliation unknown1
Rustadi SosrosumihardjoAffiliation unknown1
Andi KristantoAffiliation unknown1
Silvia SumintoAffiliation unknown1
Benny N KurniawanAffiliation unknown1
Finna ChristiantyAffiliation unknown1
Suhendro SuwartoAffiliation unknown1
Iqbal Zein AssyidiqieAffiliation unknown1
Hindra Irawan SatariAffiliation unknown1
Sri Rezeki HadinegoroAffiliation unknown1
Narottama TunjungAffiliation unknown1
Helio GuterresAffiliation unknown1
Ralalicia LimatoAffiliation unknown1
Aulia RizkaAffiliation unknown1
Soekamto KoesnoeAffiliation unknown1
Rohayat Bilmahdi SimanjuntakAffiliation unknown1
Haryanto SuryaAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Comparison of CISNE and MASCC Score in Predicting Complications on Post Chemotherapy Febrile Neutropenia</dc:title>
	<dc:creator>Shakinah, Sharifah</dc:creator>
	<dc:creator>Nelwan, Erni Juwita</dc:creator>
	<dc:creator>Lubis, Anna Mira</dc:creator>
	<dc:creator>Sinto, Robert</dc:creator>
	<dc:creator>Lie, Khie Chen</dc:creator>
	<dc:subject xml:lang="en-US">infectious disease</dc:subject>
	<dc:subject xml:lang="en-US">medical oncology</dc:subject>
	<dc:subject xml:lang="en-US">infectious disease</dc:subject>
	<dc:subject xml:lang="en-US">medical oncology</dc:subject>
	<dc:description xml:lang="en-US">Background: Febrile neutropenia (FN) is an oncologic emergency which commonly occurrs in patients who undergo chemotherapy, with a mortality rate of 12.5%. Risk stratification in FN plays an important role in increasing the accuracy of therapy. This study aims to compare the performance between CISNE score and MASCC score in predicting complications on post-chemotherapy FN in solid and hematologic malignancy.  Methods: This is a retrospective cohort study on FN patients undergoing inpatient treatment at Cipto Mangunkusumo Hospital between July 2015 and December 2019. Basic demographic and clinical data were collected from medical records. Subjects were grouped based on the CISNE and MASCC score, and complications during hospitalization were recorded. Predictive performance of each score was analyzed and compared using area of under curve.  Results: CISNE score showed a better performance both in solid malignancy with AUC of CISNE score (0.80 CI 95% 0.73-0.88, p = 0.00) compared to AUC of MASCC score (0.68; 95% CI 0.59 – 0,78, p = 0.00) and in hematologic malignancy with AUC of CISNE score (0.85; 95% CI 0.77 - 0.93, p = 0.00) and AUC MASCC score (0.65 ; 95% CI 0.54 - 0.76, p = 0.007). Conclusion: CISNE score showed a better performance compared to MASCC score in predicting in-hospital complication in both solid and hematologic malignancy with cut-off point of 2. </dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2024-10-25</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">retrospective cohort</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2772</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 56 No. 3 (2024): Acta Medica Indonesiana; 341</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2772/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 Sharifah Shakinah, Khie Chen Lie, Erni Juwita Nelwan, Anna Mira Lubis, Robert Sinto</dc:rights>
</oai_dc:dc>