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The crystal packing and slip plane analysis in mechanical properties improvement of mefenamic acid by cocrystallization with nicotinamide coformer

Communications in Science and Technology · Vol. 5 No. 2 (2020) · pp. 93–97

DOI
10.21924/cst.5.2.2020.213
ISSN
2502-9266, 2502-9258
Published
2020-12-26
Publisher
Komunitas Ilmuwan dan Profesional Muslim Indonesia
Language
eng

Abstract

Mefenamic acid is an analgesic non-steroidal anti-inflammatory drug (NSAID) that is categorized as Biopharmaceutical Classification System (BCS) class II drug. Cocrystallization of mefenamic acid (MFA) with nicotinamide (NIC) has been reported to enhance the solubility of MFA for about 2.56 times higher than pure MFA. As a part of MFA-NIC development in pharmaceutical dosage form, we reported the improvement of mechanical properties of MFA-NIC cocrystal based on the presence of slip planes in crystal structure. The research was initially by synthesizing and characterizing the cocrystal by using X-ray diffraction analysis, and was followed by the investigation of the mechanical properties of MFA and its cocrystal, i.e. tensile strength and deformation parameter. The correlation of crystal structure with mechanical properties was determined by crystal packing motif and slip plane analysis from single crystal data by using Mercury 3.6. The tensile strength of MFA was acceptance at 20.0 MPa, and dropped at more than 25.0 MPa. A better tableting performance was observed in MFA-NIC cocrystal which had the tensile strength 1.5 times higher than MFA at 12.5 MPa and gradually increased with an increasing pressure up to 2.5 times at 22.5 MPa. The flat slip plane of MFA-NIC cocrystal was predicted as the key factor in the improvement of its mechanical properties, compared to zigzag slip plane of MFA. In conclusion, MFA-NIC cocrystal had the better mechanical properties than pure MFA due to its flat slip plane and it becomes potential to be explored in further development of solid dosage form.

Keywords

Collaboration network of the authors

17 authors · 55 co-authorship links

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  • Universitas Ahmad Dahlan
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Akrom AkromUniversitas Ahmad Dahlan3
Titiek HidayatiAffiliation unknown3
Moh Aris MunandarAffiliation unknown1
Andika AndikaAffiliation unknown1
Nurkhasanah MahfudhAffiliation unknown1
Mustofa AhdaAffiliation unknown1
Siti NashihahAffiliation unknown1
Giriani Ayu SabillaAffiliation unknown1
Lukman HardiaAffiliation unknown1
Nurkhasanah NurkhasanahAffiliation unknown1
Prasasti BintarumAffiliation unknown1
Laela Hayu NuraniAffiliation unknown1
Ikhwan Dahlan RaisAffiliation unknown1
Muslih AnwarAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://cst.kipmi.or.id/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">The crystal packing and slip plane analysis in mechanical properties improvement of mefenamic acid by cocrystallization with nicotinamide coformer </dc:title>
	<dc:creator>Ari Wahyudi </dc:creator>
	<dc:creator>Utami, Dwi</dc:creator>
	<dc:creator>Setianto , Arif Budi</dc:creator>
	<dc:subject xml:lang="en-US">mefenamic acid</dc:subject>
	<dc:subject xml:lang="en-US">cocrystal</dc:subject>
	<dc:subject xml:lang="en-US">mechanical properties</dc:subject>
	<dc:subject xml:lang="en-US">slip plane</dc:subject>
	<dc:description xml:lang="en-US">Mefenamic acid is an analgesic non-steroidal anti-inflammatory drug (NSAID) that is categorized as Biopharmaceutical Classification System (BCS) class II drug. Cocrystallization of mefenamic acid (MFA) with nicotinamide (NIC) has been reported to enhance the solubility of MFA for about 2.56 times higher than pure MFA. As a part of MFA-NIC development in pharmaceutical dosage form, we reported the improvement of mechanical properties of MFA-NIC cocrystal based on the presence of slip planes in crystal structure. The research was initially by synthesizing and characterizing the cocrystal by using X-ray diffraction analysis, and was followed by the investigation of the mechanical properties of MFA and its cocrystal, i.e. tensile strength and deformation parameter. The correlation of crystal structure with mechanical properties was determined by crystal packing motif and slip plane analysis from single crystal data by using Mercury 3.6. The tensile strength of MFA was acceptance at 20.0 MPa, and dropped at more than 25.0 MPa. A better tableting performance was observed in MFA-NIC cocrystal which had the tensile strength 1.5 times higher than MFA at 12.5 MPa and gradually increased with an increasing pressure up to 2.5 times at 22.5 MPa. The flat slip plane of MFA-NIC cocrystal was predicted as the key factor in the improvement of its mechanical properties, compared to zigzag slip plane of MFA. In conclusion, MFA-NIC cocrystal had the better mechanical properties than pure MFA due to its flat slip plane and it becomes potential to be explored in further development of solid dosage form.</dc:description>
	<dc:publisher xml:lang="en-US">Komunitas Ilmuwan dan Profesional Muslim Indonesia</dc:publisher>
	<dc:date>2020-12-26</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://cst.kipmi.or.id/journal/article/view/213</dc:identifier>
	<dc:identifier>10.21924/cst.5.2.2020.213</dc:identifier>
	<dc:source xml:lang="en-US">Communications in Science and Technology; Vol. 5 No. 2 (2020); 93-97</dc:source>
	<dc:source xml:lang="id-ID">Communications in Science and Technology; Vol 5 No 2 (2020); 93-97</dc:source>
	<dc:source>2502-9266</dc:source>
	<dc:source>2502-9258</dc:source>
	<dc:source>10.21924/cst.5.2.2020</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://cst.kipmi.or.id/journal/article/view/213/76</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Communications in Science and Technology</dc:rights>
</oai_dc:dc>