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Daya hambat xylitol dan nistation terhadap pertumbuhan Candida albicans (in vitro) (Inhibition effect of xylitol and nistatin combination on Candida albicans growth (in vitro))

Dental Journal (Majalah Kedokteran Gigi) · Vol. 47 No. 3 (2014) · pp. 164–167

DOI
10.20473/j.djmkg.v47.i3.p164-167
ISSN
2442-9740, 1978-3728
Published
2014-09-01
Publisher
Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en
Language
eng

Abstract

Background: The growth of Candida albicans can be controlled by using antifungal such as nystatin. These days we found that using antifungal is not enough to control Candida albicans, we also have to control the intake of sugar by using xylitol. Purpose: Purpose of the study was to determine the optimal inhibitory concentration of xylitol-nystatin in the Candida albicans growth. Methods: This was an in-vitro study using an antimicrobial test of serial dilution with xylitol-nystatin and sucrose–nystatin consentration of 1%, 3%, 5%, 7%, 9%, and 10%.Growth inhibition of C. albicans was determined by the inhibition zone of xylitol + nystatin on C. albicans culture media (in vitro) Results: The result of study was the inhibitory consentration of xylitol-nystatin to inhibit Candida albicans growth was 3%-10%. Conclusion: The study showed that combination of xylitol and nystation could inhibit the growth of Candida albicans.Latar belakang: Pertumbuhan Candida albicans dapat dikontrol dengan menggunakan antijamur seperti nistatin. Penggunakan antijamur saja tidak cukup untuk mengontrol Candida albicans, namun perlu pula mengontrol asupan gula dengan menggunakan xylitol. Tujuan: Tujuan dari penelitian ini adalah untuk menentukan konsentrasi hambat optimal xylitol-nistatin dalam pertumbuhan Candida albicans. Metode: Penelitian ini merupakan penelitian in vitro menggunakan uji antimikroba pengenceran serial dengan xylitol-nistatin dan nystatin-sukrosa konsentrasi 1%, 3 %, 5 %, 7%, 9%, dan 10%. Daya hambat pertumbuhan C. albicans diukur dari zona hambat xylitol + nistatin pada media kultur C. albicans (in vitro) Hasil: Konsentrasi penghambatan xylitol-nistatin untuk menghambat pertumbuhan Candida albicans adalah 3-10%. Simpulan: Hasil penelitian menunjukkan bahwa kombinasi xylitol dan nystation bisa menghambat pertumbuhan Candida albicans.

Keywords

Collaboration network of the authors

34 authors · 100 co-authorship links

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  • Cenderawasih University
  • Affiliation unknown
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Co-authorOrganisationJoint articles
Tania SaskiantiAffiliation unknown2
Susilowati SusilowatiCenderawasih University1
FX SuhariadjiAffiliation unknown1
Murtia MetalitaAffiliation unknown1
Prawati NurainiAffiliation unknown1
Citra AdindaAffiliation unknown1
Teguh Budi WibowoAffiliation unknown1
Dewi Anggreani BibiAffiliation unknown1
Irmawati IrmawatiAffiliation unknown1
Tri Wijayanti PuspitasariAffiliation unknown1
Irmawati IrmawatiAffiliation unknown1
Yayi Suryo PrabandariAffiliation unknown1
Taufan BramantoroAffiliation unknown1
Djauhar IsmailAffiliation unknown1
Seno PradopoAffiliation unknown1
Dwi Mulia RamadhaniatiAffiliation unknown1
Irma Josefina SavitriAffiliation unknown1
I Komang Evan WijaksanaAffiliation unknown1
Okkinardo AriefAffiliation unknown1
Muhammad Nur FalahAffiliation unknown1
Olivia Bambang SiswantoAffiliation unknown1
Kazuhisa OuharaAffiliation unknown1
Hidemi KuriharaAffiliation unknown1
Noriyoshi MizunoAffiliation unknown1
Siti RahmawatiAffiliation unknown1
Sindy Cornelia NelwanAffiliation unknown1
Mega Moeharyono PuteriAffiliation unknown1
Dimas Prasetianto WicaksonoAffiliation unknown1
Leviena Merlynike LeoAffiliation unknown1
Hana Ai ArdianaAffiliation unknown1
Nunthawan NowwaroteAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/MKG/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Daya hambat xylitol dan nistation terhadap pertumbuhan Candida albicans (in vitro) (Inhibition effect of xylitol and nistatin combination on Candida albicans growth (in vitro))</dc:title>
	<dc:creator>Djajusman, Sarah Kartimah</dc:creator>
	<dc:creator>Tedjosasongko, Udijanto</dc:creator>
	<dc:creator>Irmawati, Irmawati</dc:creator>
	<dc:subject xml:lang="en-US">Candida albicans</dc:subject>
	<dc:subject xml:lang="en-US">xylitol</dc:subject>
	<dc:subject xml:lang="en-US">sucrose</dc:subject>
	<dc:subject xml:lang="en-US">nystatin</dc:subject>
	<dc:subject xml:lang="en-US">inhibitory concentration</dc:subject>
	<dc:subject xml:lang="en-US">sukrosa</dc:subject>
	<dc:subject xml:lang="en-US">nistatin</dc:subject>
	<dc:subject xml:lang="en-US">konsentrai daya hambat</dc:subject>
	<dc:description xml:lang="en-US">Background: The growth of Candida albicans can be controlled by using antifungal such as nystatin. These days we found that using antifungal is not enough to control Candida albicans, we also have to control the intake of sugar by using xylitol. Purpose: Purpose of the study was to determine the optimal inhibitory concentration of xylitol-nystatin in the Candida albicans growth. Methods: This was an in-vitro study using an antimicrobial test of serial dilution with xylitol-nystatin and sucrose–nystatin consentration of 1%, 3%, 5%, 7%, 9%, and 10%.Growth inhibition of C. albicans was determined by the inhibition zone of xylitol + nystatin on C. albicans culture media (in vitro) Results: The result of study was the inhibitory consentration of xylitol-nystatin to inhibit Candida albicans growth was 3%-10%. Conclusion: The study showed that combination of xylitol and nystation could inhibit the growth of Candida albicans.Latar belakang: Pertumbuhan Candida albicans dapat dikontrol dengan menggunakan antijamur seperti nistatin. Penggunakan antijamur saja tidak cukup untuk mengontrol Candida albicans, namun perlu pula mengontrol asupan gula dengan menggunakan xylitol. Tujuan: Tujuan dari penelitian ini adalah untuk menentukan konsentrasi hambat optimal xylitol-nistatin dalam pertumbuhan Candida albicans. Metode: Penelitian ini merupakan penelitian in vitro menggunakan uji antimikroba pengenceran serial dengan xylitol-nistatin dan nystatin-sukrosa konsentrasi 1%, 3 %, 5 %, 7%, 9%, dan 10%. Daya hambat pertumbuhan C. albicans diukur dari zona hambat xylitol + nistatin pada media kultur C. albicans (in vitro) Hasil: Konsentrasi penghambatan xylitol-nistatin untuk menghambat pertumbuhan Candida albicans adalah 3-10%. Simpulan: Hasil penelitian menunjukkan bahwa kombinasi xylitol dan nystation bisa menghambat pertumbuhan Candida albicans.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en</dc:publisher>
	<dc:date>2014-09-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/MKG/article/view/728</dc:identifier>
	<dc:identifier>10.20473/j.djmkg.v47.i3.p164-167</dc:identifier>
	<dc:source xml:lang="en-US">Dental Journal (Majalah Kedokteran Gigi); Vol. 47 No. 3 (2014): September 2014; 164-167</dc:source>
	<dc:source>2442-9740</dc:source>
	<dc:source>1978-3728</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/728/510</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2015 Dental Journal (Majalah Kedokteran Gigi)</dc:rights>
</oai_dc:dc>