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Maternal endotoxin-induced fetal growth restriction in rats: Fetal responses in toll-like receptor

Dental Journal (Majalah Kedokteran Gigi) · Vol. 45 No. 3 (2012) · pp. 144–149

DOI
10.20473/j.djmkg.v45.i3.p144-149
ISSN
2442-9740, 1978-3728
Published
2012-09-01
Publisher
Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en
Language
eng

Abstract

Background: Porphyromonas gingivalis as a major etiology of periodontal disease can produce virulence factor, lipopolysaccharide/LPS, which is expected to play a role in the intrauterine fetal growth. Trophoblast at the maternal-fetal interface actively participates in response to infection through the expression of a family of natural immune receptors, toll-like receptor (TLR). Purpose: the aims of study were to identify endotoxin concentration in maternal blood serum of Porphyromonas gingivalis-infected pregnant rats, to characterize the TLR-4 expression in trophoblast cells, and to determine its effect on fetal growth. Methods: Female rats were infected with live-Porphyromonas gingivalis at concentration of 2 x 109 cells/ml into subgingival sulcus area of the maxillary first molar before and/or during pregnancy. They were sacrified on 14th and 20th gestational day. Fetuses were evaluated for weight and length. Endotoxin was detected by limulus amebocyte lysate assay in the maternal blood serum. The TLR-4 expression in trophoblast cells was detected by immunohistochemistry. <span style="font-family: Tribune-Bold; font-size:

Collaboration network of the authors

40 authors · 91 co-authorship links · 4 across different organisations · showing the 40 most connected

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  • Universitas Gadjah Mada
  • Sriwijaya University
  • Universitas Negeri Surabaya
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Michael Haryadi WibowoAffiliation unknown4
Wayan T. ArtamaAffiliation unknown3
Al. Supartinah SantosoAffiliation unknown3
Arum SetiawanSriwijaya University2
Mammed SagiUniversitas Gadjah Mada2
Istriyati IstriyatiUniversitas Gadjah Mada2
Dwi Merry Christmarini RobinAffiliation unknown2
Endah PuspitasariAffiliation unknown2
Jaka WidadaUniversitas Gadjah Mada2
M. MustofaAffiliation unknown2
A. AlimuddinAffiliation unknown2
SEBASTIAN MARGINOAffiliation unknown2
W. WidodoUniversitas Negeri Surabaya2
Sri DarmawatiAffiliation unknown2
LANGKAH SEMBIRINGAffiliation unknown2
Tri UntariAffiliation unknown2
Dewi AgustinaAffiliation unknown2
Siti SunarintyasAffiliation unknown2
Totok UtoroAffiliation unknown2
Regina TC. TandelilinAffiliation unknown2
Edy MeiyantoAffiliation unknown2
Sitti Rahmah UmniyatiAffiliation unknown1
Soroy LardoAffiliation unknown1
Juffrie JuffrieAffiliation unknown1
Archadian NuryantiAffiliation unknown1
Pinandi Sri PudyaniAffiliation unknown1
Ika Dewi AnaAffiliation unknown1
Tita Ratya UtariAffiliation unknown1
Juni HandajaniAffiliation unknown1
Yulita KristantiAffiliation unknown1
Risya CilmiatyAffiliation unknown1
Mandojo RukmoAffiliation unknown1
Afiono Agung PrasetyoAffiliation unknown1
Khilyat Ulin Nur ZainiAffiliation unknown1
Suhartono Taat PutraAffiliation unknown1
Didin Erma IndahyaniAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/MKG/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Maternal endotoxin-induced fetal growth restriction in rats: Fetal responses in toll-like receptor</dc:title>
	<dc:creator>Kusumawardani, Banun</dc:creator>
	<dc:creator>Soesatyo, Marsetyawan HNE.</dc:creator>
	<dc:creator>Dasuki, Djaswadi</dc:creator>
	<dc:creator>Asmara, Widya</dc:creator>
	<dc:description xml:lang="en-US">Background: Porphyromonas gingivalis as a major etiology of periodontal disease can produce virulence factor, lipopolysaccharide/LPS, which is expected to play a role in the intrauterine fetal growth. Trophoblast at the maternal-fetal interface actively participates in response to infection through the expression of a family of natural immune receptors, toll-like receptor (TLR). Purpose: the aims of study were to identify endotoxin concentration in maternal blood serum of Porphyromonas gingivalis-infected pregnant rats, to characterize the TLR-4 expression in trophoblast cells, and to determine its effect on fetal growth. Methods: Female rats were infected with live-Porphyromonas gingivalis at concentration of 2 x 109 cells/ml into subgingival sulcus area of the maxillary first molar before and/or during pregnancy. They were sacrified on 14th and 20th gestational day. Fetuses were evaluated for weight and length. Endotoxin was detected by limulus amebocyte lysate assay in the maternal blood serum. The TLR-4 expression in trophoblast cells was detected by immunohistochemistry. &amp;lt;span style="font-family: Tribune-Bold; font-size:</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en</dc:publisher>
	<dc:date>2012-09-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
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	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/MKG/article/view/817</dc:identifier>
	<dc:identifier>10.20473/j.djmkg.v45.i3.p144-149</dc:identifier>
	<dc:source xml:lang="en-US">Dental Journal (Majalah Kedokteran Gigi); Vol. 45 No. 3 (2012): September 2012; 144-149</dc:source>
	<dc:source>2442-9740</dc:source>
	<dc:source>1978-3728</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/817/600</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2015 Dental Journal (Majalah Kedokteran Gigi)</dc:rights>
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