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Effect of oxygen hyperbaric therapy on malondialdehyde levels in saliva of periodontitis patients with type 2 diabetes mellitus

Dental Journal (Majalah Kedokteran Gigi) · Vol. 41 No. 4 (2008) · pp. 151–154

DOI
10.20473/j.djmkg.v41.i4.p151-154
ISSN
2442-9740, 1978-3728
Published
2008-12-01
Publisher
Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en
Language
eng

Abstract

Background: Lipid peroxidation (LPO) has implication in pathogenesis of several pathological disorders including periodontitis. Malondialdehyde (MDA) is end products of upid peroxidation. Hyperbaric Oxygen Therapy (HBOT) involves the administration of 100% oxygen under atmosphere pressure and has been used as an adjuvant therapy, while saliva is a diagnostic tool for many oral and systemic diseases. Purpose: The aim of this study was to examine the effect of HBOT on malondialdehyde in saliva to measure lipid peroxidation in periodontitis patients with type 2 Diabetes Mellitus (DM). Methods: Eight regulated type 2 DM subjects were compared to ten unregulated periodontitis patients type 2 DM (n = 18). Pre HBOT and after 10 days HBOT with 2.4 ATA dose, unstimulated whole saliva samples from study subjects were collected, centrifuged at 3000 g for 15 minutes and were then stored at −80° C until analyzed. The MDA level was determined with 2-thiobarbituric acid by a colorimetric method at 532 nm. Results: Data showed that regulated type 2 DM had lower level of MDA (3.08 ± 0.62 ug/mol) compared with unregulated periodontally- type 2 DM subjects (5.88 ± 1.04 ug/mol) (p>0.05). MDA levels were significantly lower after HBOT in regulated DM (2.30 ± 0.46 ug/mol) compared with unregulated periodontally type 2 DM (4.09 ± 0.77ug/mol) (p < 0.05). The regulated DM subjects and post HBOT showed MDA levels lower than the periodontally-unregulated group significantly. Conclusion: The saliva of periodontitis patients with unregulated type 2 DM showed more lipid peroxidation than regulated DM type 2. HBOT decreased MDA levels in regulated and unregulated type 2 DM with periodontitis.

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Dian Widya DamaiyantiAffiliation unknown3
Dwi Yan NugrahaAffiliation unknown1
Dian NugrahaAffiliation unknown1
Muh DaudAffiliation unknown1
Ahmad RidfahAffiliation unknown1
Harry PramonoAffiliation unknown1
Rumini RuminiAffiliation unknown1
Nur Afni IndahariAffiliation unknown1
Mutmainnah Nur Rahma MajidAffiliation unknown1
Anna RozaliyaniAffiliation unknown1
Ary Indriana SavitriAffiliation unknown1
Findra SetianingrumAffiliation unknown1
Titania Nur ShellyAffiliation unknown1
Vini RatnasariAffiliation unknown1
Romala KuswindartiAffiliation unknown1
Ngabila SalamaAffiliation unknown1
Dwi OktaviaAffiliation unknown1
Diah HandayaniAffiliation unknown1
Rima Parwati SariAffiliation unknown1
Kristanti ParisihniAffiliation unknown1
Dwi AndrianiAffiliation unknown1
Farizia Putri KhoirunnisaAffiliation unknown1
Alifati Nita JuliatinAffiliation unknown1
W WidyastutiAffiliation unknown1
Cindy Aprilia SariAffiliation unknown1
Diah Ayu SiwiAffiliation unknown1
Slamet SuprayogiAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/MKG/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Effect of oxygen hyperbaric therapy on malondialdehyde levels in saliva of periodontitis patients with type 2 diabetes mellitus</dc:title>
	<dc:creator>Mulawarmanti, Dian</dc:creator>
	<dc:creator>Widyastuti, Widyastuti</dc:creator>
	<dc:subject xml:lang="en-US">hyperbaric oxygen</dc:subject>
	<dc:subject xml:lang="en-US">malondialdehyde</dc:subject>
	<dc:subject xml:lang="en-US">saliva</dc:subject>
	<dc:description xml:lang="en-US">Background: Lipid peroxidation (LPO) has implication in pathogenesis of several pathological disorders including periodontitis. Malondialdehyde (MDA) is end products of upid peroxidation. Hyperbaric Oxygen Therapy (HBOT) involves the administration of 100% oxygen under atmosphere pressure and has been used as an adjuvant therapy, while saliva is a diagnostic tool for many oral and systemic diseases. Purpose: The aim of this study was to examine the effect of HBOT on malondialdehyde in saliva to measure lipid peroxidation in periodontitis patients with type 2 Diabetes Mellitus (DM). Methods: Eight regulated type 2 DM subjects were compared to ten unregulated periodontitis patients type 2 DM (n = 18). Pre HBOT and after 10 days HBOT with 2.4 ATA dose, unstimulated whole saliva samples from study subjects were collected, centrifuged at 3000 g for 15 minutes and were then stored at −80° C until analyzed. The MDA level was determined with 2-thiobarbituric acid by a colorimetric method at 532 nm. Results: Data showed that regulated type 2 DM had lower level of MDA (3.08 ± 0.62 ug/mol) compared with unregulated periodontally- type 2 DM subjects (5.88 ± 1.04 ug/mol) (p&amp;gt;0.05). MDA levels were significantly lower after HBOT in regulated DM (2.30 ± 0.46 ug/mol) compared with unregulated periodontally type 2 DM (4.09 ± 0.77ug/mol) (p &amp;lt; 0.05). The regulated DM subjects and post HBOT showed MDA levels lower than the periodontally-unregulated group significantly. Conclusion: The saliva of periodontitis patients with unregulated type 2 DM showed more lipid peroxidation than regulated DM type 2. HBOT decreased MDA levels in regulated and unregulated type 2 DM with periodontitis.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en</dc:publisher>
	<dc:date>2008-12-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/MKG/article/view/981</dc:identifier>
	<dc:identifier>10.20473/j.djmkg.v41.i4.p151-154</dc:identifier>
	<dc:source xml:lang="en-US">Dental Journal (Majalah Kedokteran Gigi); Vol. 41 No. 4 (2008): December 2008; 151-154</dc:source>
	<dc:source>2442-9740</dc:source>
	<dc:source>1978-3728</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/981/764</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2015 Dental Journal (Majalah Kedokteran Gigi)</dc:rights>
</oai_dc:dc>