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Roles of secretory leukocyte protease inhibitor amniotic membrane in oral wound healing

Dental Journal (Majalah Kedokteran Gigi) · Vol. 39 No. 4 (2006) · pp. 172–176

DOI
10.20473/j.djmkg.v39.i4.p172-176
ISSN
2442-9740, 1978-3728
Published
2006-12-01
Publisher
Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en
Language
eng

Abstract

Secretory Leukocyte Protease Inhibitor (SLPI) is serine protease inhibitor. Secretory Leukocyte Protease Inhibitor is a protein found in secretions such as whole saliva, seminal fluid, cervical mucus, synovial fluid, breast milk, tears, and cerebral spinal fluid, as in secretions from the nose and bronchi, amniotic fluid and amniotic membrane etc. These findings demonstrate that SLPI function as a potent anti protease, anti inflammatory, bactericidal, antifungal, tissue repair, extra cellular synthesis. Impaired healing states are characterized by excessive proteolysis and often bacterial infection, leading to the hypothesis that SLPI may have a role in the process. The objectives of this article are to investigate the role of SLPI in oral inflammation and how it contributes to tissue repair in oral mucosa. The oral wound healing responses are impaired in the SLPI sufficient mice and matrix synthesis and collagen deposition are delayed. This study indicated that SLPI is a povital factor necessary for optimal wound healing.

Keywords

Collaboration network of the authors

23 authors · 83 co-authorship links

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Co-authorOrganisationJoint articles
Devi RiantiAffiliation unknown2
Anita YuliatiAffiliation unknown2
Titien Hary AgustantinaAffiliation unknown2
David DavidAffiliation unknown1
Agni Febrina PargaputriAffiliation unknown1
Retno IndrawatiAffiliation unknown1
Retno Pudji RahayuAffiliation unknown1
Fitria RahmitasariAffiliation unknown1
Indah Listiana KriswandiniAffiliation unknown1
Moh. Basroni RizalAffiliation unknown1
Intan Fajrin ArsyadaAffiliation unknown1
Muhammad Riza Hafidz BahtiarAffiliation unknown1
OctarinaAffiliation unknown1
Rizki Fauziah SalmaAffiliation unknown1
Ajeng Putri MeyrantiAffiliation unknown1
Fathilah Abdul RazakAffiliation unknown1
FaradillahAffiliation unknown1
Asti MeizariniAffiliation unknown1
Alqomariyah Eka PurnamasariAffiliation unknown1
Rifayinqa Ruyani PutriAffiliation unknown1
Noor Zain SalsabillaAffiliation unknown1
Ardiyansyah SyahromAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/MKG/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Roles of secretory leukocyte protease inhibitor amniotic membrane in oral wound healing</dc:title>
	<dc:creator>Munadziroh, Elly</dc:creator>
	<dc:subject xml:lang="en-US">Secretory leukocyte protease inhibitor</dc:subject>
	<dc:subject xml:lang="en-US">amniotic membrane</dc:subject>
	<dc:subject xml:lang="en-US">oral wound healing</dc:subject>
	<dc:description xml:lang="en-US">Secretory Leukocyte Protease Inhibitor (SLPI) is serine protease inhibitor. Secretory Leukocyte Protease Inhibitor is a protein found in secretions such as whole saliva, seminal fluid, cervical mucus, synovial fluid, breast milk, tears, and cerebral spinal fluid, as in secretions from the nose and bronchi, amniotic fluid and amniotic membrane etc. These findings demonstrate that SLPI function as a potent anti protease, anti inflammatory, bactericidal, antifungal, tissue repair, extra cellular synthesis. Impaired healing states are characterized by excessive proteolysis and often bacterial infection, leading to the hypothesis that SLPI may have a role in the process. The objectives of this article are to investigate the role of SLPI in oral inflammation and how it contributes to tissue repair in oral mucosa. The oral wound healing responses are impaired in the SLPI sufficient mice and matrix synthesis and collagen deposition are delayed. This study indicated that SLPI is a povital factor necessary for optimal wound healing.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en</dc:publisher>
	<dc:date>2006-12-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/MKG/article/view/1082</dc:identifier>
	<dc:identifier>10.20473/j.djmkg.v39.i4.p172-176</dc:identifier>
	<dc:source xml:lang="en-US">Dental Journal (Majalah Kedokteran Gigi); Vol. 39 No. 4 (2006): December 2006; 172-176</dc:source>
	<dc:source>2442-9740</dc:source>
	<dc:source>1978-3728</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/1082/865</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2015 Dental Journal (Majalah Kedokteran Gigi)</dc:rights>
</oai_dc:dc>