Degradation of chitosan–gelatin and chitosan–gelatin–β-tricalcium phosphate scaffolds

Putri, Tansza Setiana; Pratiwi, Deviyanti; Margaretta, Dewi Liliany; Tjandrawinata, Rosalina; Shariff, Khairul Anuar

doi:10.20473/j.djmkg.v57.i2.p87-90

Open access Journal SINTA 1

Degradation of chitosan–gelatin and chitosan–gelatin–β-tricalcium phosphate scaffolds

Dental Journal (Majalah Kedokteran Gigi) · Vol. 57 No. 2 (2024) · pp. 87–90

DOI: 10.20473/j.djmkg.v57.i2.p87-90
ISSN: 2442-9740, 1978-3728
Published: 2024-04-02
Publisher: Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en
Language: eng
License: creativecommons.org/licenses/by-sa/4.0

Abstract

Background: Fabrication of the composite scaffold was carried out by combining chitosan, gelatin, and β-tricalcium phosphate (βTCP) derived from limestone. The extraction of βTCP was based on the abundance of limestone containing calcium carbonate, which can be a source of βTCP synthesis. Purpose: This study evaluates the degradation of the combination of chitosan–gelatin (ChG) and chitosan–gelatin–βTCP (ChG-βTCP) composite scaffolds. Methods: The freeze-drying method was used to obtain the composite scaffold, which was a mixture of chitosan, gelatin, and βTCP. Degradation was measured by immersing the samples in a simulated body fluid solution at 37°C for 3, 7, 14, and 21 days. For statistical analysis, one-way analysis of variance (ANOVA) and post hoc Fisher's least significant difference were performed. Results: The ChG scaffold shows better degradability than the ChG-βTCP scaffold. The ChG scaffold shows higher weight degradation than the ChG-βTCP scaffold up to 21 days. Conclusion: In conclusion, the scaffold containing βTCP has lower degradation than the ChG scaffold.

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Co-author	Organisation	Joint articles
Eddy	Affiliation unknown	6
Thet Thet Swe	Affiliation unknown	4
Abida Zhafira Inayasary	Affiliation unknown	3
Juan Cassius Halim	Affiliation unknown	2
Florencia Livia	Affiliation unknown	2
Rafhaela Johanna Halim	Affiliation unknown	2
Akhmad Endang Zainal Hasan	Affiliation unknown	1
Richentya Feiby Salim	Affiliation unknown	1
Tansza Permata Setiana Putri	Affiliation unknown	1
Jackson Dipankara	Affiliation unknown	1
Gary Hadrian	Affiliation unknown	1
Astri Rinanti	Affiliation unknown	1
Wiwiek Poedjiastoeti	Affiliation unknown	1
Poppy Andriani	Affiliation unknown	1
Ade Prijanti Dwisaptarini	Affiliation unknown	1
Eko Fibryanto	Affiliation unknown	1
Siriwan Suebnukarn	Affiliation unknown	1
Elline	Affiliation unknown	1
Anastasia Elsa Prahasti	Affiliation unknown	1
Winny Moniaga	Affiliation unknown	1
Syuwari Azhar Azman	Affiliation unknown	1
Dianayu Noviani Soesianto Putri	Affiliation unknown	1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/MKG/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.

Original metadata (oai_dc)

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	<dc:title xml:lang="en-US">Degradation of chitosan–gelatin and chitosan–gelatin–β-tricalcium phosphate scaffolds</dc:title>
	<dc:creator>Putri, Tansza Setiana</dc:creator>
	<dc:creator>Pratiwi, Deviyanti</dc:creator>
	<dc:creator>Margaretta, Dewi Liliany</dc:creator>
	<dc:creator>Tjandrawinata, Rosalina</dc:creator>
	<dc:creator>Shariff, Khairul Anuar</dc:creator>
	<dc:subject xml:lang="en-US">β-tricalcium phosphate</dc:subject>
	<dc:subject xml:lang="en-US">chitosan</dc:subject>
	<dc:subject xml:lang="en-US">gelatin</dc:subject>
	<dc:subject xml:lang="en-US">degradation</dc:subject>
	<dc:subject xml:lang="en-US">bone tissue engineering</dc:subject>
	<dc:description xml:lang="en-US">Background: Fabrication of the composite scaffold was carried out by combining chitosan, gelatin, and β-tricalcium phosphate (βTCP) derived from limestone. The extraction of βTCP was based on the abundance of limestone containing calcium carbonate, which can be a source of βTCP synthesis. Purpose: This study evaluates the degradation of the combination of chitosan–gelatin (ChG) and chitosan–gelatin–βTCP (ChG-βTCP) composite scaffolds. Methods: The freeze-drying method was used to obtain the composite scaffold, which was a mixture of chitosan, gelatin, and βTCP. Degradation was measured by immersing the samples in a simulated body fluid solution at 37°C for 3, 7, 14, and 21 days. For statistical analysis, one-way analysis of variance (ANOVA) and post hoc Fisher's least significant difference were performed. Results: The ChG scaffold shows better degradability than the ChG-βTCP scaffold. The ChG scaffold shows higher weight degradation than the ChG-βTCP scaffold up to 21 days. Conclusion: In conclusion, the scaffold containing βTCP has lower degradation than the ChG scaffold.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en</dc:publisher>
	<dc:date>2024-04-02</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>text/xml</dc:format>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/MKG/article/view/44064</dc:identifier>
	<dc:identifier>10.20473/j.djmkg.v57.i2.p87-90</dc:identifier>
	<dc:source xml:lang="en-US">Dental Journal (Majalah Kedokteran Gigi); Vol. 57 No. 2 (2024): June; 87-90</dc:source>
	<dc:source>2442-9740</dc:source>
	<dc:source>1978-3728</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/44064/39548</dc:relation>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/44064/28365</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 Dental Journal</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>