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Intravenous Versus Intraarterial Transplantation of Human Umbilical Cord Blood Mononuclear Cells for Brain Ischemia in Rats

HAYATI Journal of Biosciences · Vol. 24 No. 4 (2018)

DOI
10.4308/hjb.24.4.187
ISSN
2086-4094, 1978-3019
Published
2018-03-27
Publisher
Bogor Agricultural University, Indonesia
Language
eng

Abstract

Cerebral ischemia is among the most common type of stroke seen in patient. Regeneration of death neurons remains questionable. Human umbilical cord blood mononuclear cell(cbMNC) is one of the treatment options for ischemia stroke through their various advantages; availability, pluripotency, and immaturity. One group of healthy rats and three groups (n = 6 per group) of male Wistar rats undergone permanent middle cerebral artery occlusion (MCAO). Rats were allowed to recover for 7 days before intraarterial and intravenous injection of 1 × 106 cells/kg of human cbMNC. Behavioral tests were performed before the MCAO, 1 week after MCAO, and at 3, 9, and 14 days after cbMNC injection. Brain infarct area and neurons in hippocampus were evaluated. Spontaneous activity was much significantly improved compared with the placebo group (p < 0.05). Comparing the neuron cells in hippocampus, intraarterial and intravenous have more changes in neurons morphology. No effect of cbMNC implantation in decreasing infarct area. Safety of xenogenic was confirmed by this study when the dosage of 1 × 106 cells/kg was used and showed their beneficial effects.

Keywords

Collaboration network of the authors

40 authors · 157 co-authorship links · 1 across different organisations · showing the 40 most connected

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  • Universitas Negeri Surabaya
  • Jenderal Soedirman University
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Arief BoedionoAffiliation unknown3
RIKA RAFFIUDINAffiliation unknown3
Windra PriawandiputraAffiliation unknown3
Fahri FahriUniversitas Negeri Surabaya2
Tri AtmowidiAffiliation unknown2
Nisfia Rakhmatun NisaAffiliation unknown2
Telly KameliaAffiliation unknown2
Reyhan Eddy YunusAffiliation unknown2
Mokhamad FahrudinAffiliation unknown1
Vista BudiariatiAffiliation unknown1
Dwi BudionoAffiliation unknown1
Ratih RinendyaputriAffiliation unknown1
Puji LestariJenderal Soedirman University1
Araz MeilinAffiliation unknown1
Yulia PujiastutiAffiliation unknown1
Jauharlina JauharlinaAffiliation unknown1
Mahardika Gama PradanaAffiliation unknown1
Jasmi JasmiAffiliation unknown1
Innayah ZaharaAffiliation unknown1
Jacobus S.A LamerkabelAffiliation unknown1
Qashiratuttarafi QashiratuttarafiAffiliation unknown1
Kukuh NirmalaAffiliation unknown1
Iffi RizkiyaAffiliation unknown1
Dewi PuspaningsihAffiliation unknown1
Imam TaufikAffiliation unknown1
Sigit Daru CahayadiAffiliation unknown1
Nur Aisyah NuzuliaAffiliation unknown1
Ifty AhmedAffiliation unknown1
Retno Wahyu NurhayatiAffiliation unknown1
Yessie Widya SariAffiliation unknown1
Johan IskandarAffiliation unknown1
Ayu Savitri NurinsiyahAffiliation unknown1
Meilisha Putri PertiwiAffiliation unknown1
Astuti LatifAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://journal.ipb.ac.id/index.php/hayati/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">Intravenous Versus Intraarterial Transplantation of Human Umbilical Cord Blood Mononuclear Cells for Brain Ischemia in Rats</dc:title>
	<dc:creator xml:lang="en">Ramli, Yetty</dc:creator>
	<dc:creator xml:lang="en">Alwahdy, Ahmad Sulaiman</dc:creator>
	<dc:creator xml:lang="en">Kurniawan, Mohammad</dc:creator>
	<dc:creator xml:lang="en">Juliandi, Berry</dc:creator>
	<dc:creator xml:lang="en">Wuyung, Puspita Eka</dc:creator>
	<dc:creator xml:lang="en">Susanto, Yayi Dwina Bilianti</dc:creator>
	<dc:subject xml:lang="en">human umbilical cord blood</dc:subject>
	<dc:subject xml:lang="en">middle cerebral artery occlusion</dc:subject>
	<dc:subject xml:lang="en">monofilament</dc:subject>
	<dc:subject xml:lang="en">mononuclear cells</dc:subject>
	<dc:subject xml:lang="en">rats</dc:subject>
	<dc:description xml:lang="en">Cerebral ischemia is among the most common type of stroke seen in patient. Regeneration of death neurons remains questionable. Human umbilical cord blood mononuclear cell(cbMNC) is one of the treatment options for ischemia stroke through their various advantages; availability, pluripotency, and immaturity. One group of healthy rats and three groups (n = 6 per group) of male Wistar rats undergone permanent middle cerebral artery occlusion (MCAO). Rats were allowed to recover for 7 days before intraarterial and intravenous injection of 1 × 106 cells/kg of human cbMNC. Behavioral tests were performed before the MCAO, 1 week after MCAO, and at 3, 9, and 14 days after cbMNC injection. Brain infarct area and neurons in hippocampus were evaluated. Spontaneous activity was much significantly improved compared with the placebo group (p &amp;lt; 0.05). Comparing the neuron cells in hippocampus, intraarterial and intravenous have more changes in neurons morphology. No effect of cbMNC implantation in decreasing infarct area. Safety of xenogenic was confirmed by this study when the dosage of 1 × 106 cells/kg was used and showed their beneficial effects.</dc:description>
	<dc:publisher xml:lang="en">Bogor Agricultural University, Indonesia</dc:publisher>
	<dc:date>2018-03-27</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://journal.ipb.ac.id/hayati/article/view/20827</dc:identifier>
	<dc:identifier>10.4308/hjb.24.4.187</dc:identifier>
	<dc:source xml:lang="en">HAYATI Journal of Biosciences; Vol. 24 No. 4 (2017): October 2017; 187</dc:source>
	<dc:source>2086-4094</dc:source>
	<dc:source>1978-3019</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://journal.ipb.ac.id/hayati/article/view/20827/14268</dc:relation>
</oai_dc:dc>