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Expression of APP, CDK5, and AKT1 Gene Related to Alzheimer Disease in Brain of Long-tailed Macaques

HAYATI Journal of Biosciences · Vol. 31 No. 1 (2023) · pp. 145–152

DOI
10.4308/hjb.31.1.145-152
ISSN
2086-4094, 1978-3019
Published
2023-10-22
Publisher
Bogor Agricultural University, Indonesia
Language
eng

Abstract

Amyloid plaques and Neurofibrillary Tangles (NFTs) are known to be key pathological features of Alzheimer disease. To gain a better understanding of this disease, studies were carried out on the Indonesian primates, the long-tailed macaques, using a spontaneous Alzheimer's disease model. Examining and identifying genetic markers involved in plaque formation and NFTs in long-tailed macaques is necessary to reveal their physiological processes. In this study, the expression of genes involved in the development of amyloid plaque (Amyloid Precursor Protein (APP)) and those that control the phosphorylation of tau protein (CDK5 and AKT1) was examined in the long-tailed macaque brain. This study showed that APP, CDK5, and AKT1 may potentially be developed as genetic markers of Alzheimer's disease. Long-tailed macaques exhibited the development of amyloid plaque in the aging brain based on the analysis of the gene expression profile of its biomarker. Furthermore, long-tailed macaques can be optimized for neurodegenerative models.

Collaboration network of the authors

40 authors · 145 co-authorship links · showing the 40 most connected

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Co-authorOrganisationJoint articles
Silmi MariyaAffiliation unknown5
DONDIN SAJUTHIAffiliation unknown4
Arief BoedionoAffiliation unknown4
. YulianaAffiliation unknown4
Bagus Priyo PurwantoAffiliation unknown2
Fitra Aji PamungkasAffiliation unknown2
Riasari Gail SianturiAffiliation unknown2
Mohamad RafiAffiliation unknown2
I Wayan Teguh WibawanAffiliation unknown2
NASTITI KUSUMORINIAffiliation unknown2
I NENGAH BUDIARSAAffiliation unknown2
Ridwan AffandiAffiliation unknown2
Andriyanto AndriyantoAffiliation unknown2
Aulia Andi MustikaAffiliation unknown2
DIAH ISKANDRIATIAffiliation unknown2
Joko PamungkasAffiliation unknown2
Dyah Perwitasari-FarajallahAffiliation unknown2
Ahmad YaniAffiliation unknown1
Sultania A SulemanAffiliation unknown1
Aryani Sismin SatyaningtijasAffiliation unknown1
Resti Rahma DiantiAffiliation unknown1
Alif Iman FitriantoAffiliation unknown1
Adkhilni UtamiAffiliation unknown1
Wining AstiniAffiliation unknown1
Adisti DwijayantiAffiliation unknown1
Frans Dhyanagiri SuyatnaAffiliation unknown1
Kelvin YapriantoAffiliation unknown1
Indra BachtiarAffiliation unknown1
Wildayati WildayatiAffiliation unknown1
Hera MaheshwariAffiliation unknown1
Etih SudarnikaAffiliation unknown1
Maria Fatima PalupiAffiliation unknown1
REVOLSON ALEXIUS MEGEAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://journal.ipb.ac.id/index.php/hayati/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">Expression of APP, CDK5, and AKT1 Gene Related to Alzheimer Disease in Brain of Long-tailed Macaques</dc:title>
	<dc:creator xml:lang="en">Rosmanah, Lis</dc:creator>
	<dc:creator xml:lang="en">Saepuloh, Uus</dc:creator>
	<dc:creator xml:lang="en">Mariya, Sela Septima</dc:creator>
	<dc:creator xml:lang="en">Suparto, Irma Herawati</dc:creator>
	<dc:creator xml:lang="en">Manalu, Wasmen</dc:creator>
	<dc:creator xml:lang="en">Winarto, Adi</dc:creator>
	<dc:creator xml:lang="en">Darusman, Huda Shalahudin</dc:creator>
	<dc:description xml:lang="en">Amyloid plaques and Neurofibrillary Tangles (NFTs) are known to be key pathological features of Alzheimer disease. To gain a better understanding of this disease, studies were carried out on the Indonesian primates, the long-tailed macaques, using a spontaneous Alzheimer's disease model. Examining and identifying genetic markers involved in plaque formation and NFTs in long-tailed macaques is necessary to reveal their physiological processes. In this study, the expression of genes involved in the development of amyloid plaque (Amyloid Precursor Protein (APP)) and those that control the phosphorylation of tau protein (CDK5 and AKT1) was examined in the long-tailed macaque brain. This study showed that APP, CDK5, and AKT1 may potentially be developed as genetic markers of Alzheimer's disease. Long-tailed macaques exhibited the development of amyloid plaque in the aging brain based on the analysis of the gene expression profile of its biomarker. Furthermore, long-tailed macaques can be optimized for neurodegenerative models.</dc:description>
	<dc:publisher xml:lang="en">Bogor Agricultural University, Indonesia</dc:publisher>
	<dc:date>2023-10-22</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://journal.ipb.ac.id/hayati/article/view/43980</dc:identifier>
	<dc:identifier>10.4308/hjb.31.1.145-152</dc:identifier>
	<dc:source xml:lang="en">HAYATI Journal of Biosciences; Vol. 31 No. 1 (2024): January 2024; 145-152</dc:source>
	<dc:source>2086-4094</dc:source>
	<dc:source>1978-3019</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://journal.ipb.ac.id/hayati/article/view/43980/26497</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2023 Lis Rosmanah, Uus Saepuloh, Sela Septima Mariya, Irma Herawati Suparto, Wasmen Manalu, Adi Winarto, Huda Shalahudin Darusman</dc:rights>
</oai_dc:dc>