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Immune Response to Capsular Polysaccharide of Streptococcus pneumoniae in Rabbits Immunized with Pneumococcal Conjugate Vaccine

HAYATI Journal of Biosciences · Vol. 32 No. 3 (2025) · pp. 642–648

DOI
10.4308/hjb.32.3.642-648
ISSN
2086-4094, 1978-3019
Published
2025-01-24
Publisher
Bogor Agricultural University, Indonesia
Language
eng

Abstract

To evaluate the immune response of a rabbit model to polysaccharide capsules of Streptococcus pneumoniae after primary and booster immunization with pneumococcal conjugate vaccine. Rabbits were immunized with 0.25 ml of the 13-valent pneumococcal conjugate vaccine (PCV13) on Day 0, 7, and 14. Blood of rabbits was collected to measure the specific antibodies against the native polysaccharide capsules of S. pneumoniae serotypes 6B (Anti-Pn6BPS antibodies) and 19F (Anti-19FPS antibodies) using enzyme-linked immunosorbent assay (ELISA). The specific anti-Pn6BPS and anti-Pn19FPS antibodies in the immunized group increased significantly compared to the control rabbit after immunization (P<0.05). The highest titer of anti-Pn6BPS and anti-Pn19FPS antibodies were obtained on Day 21 and Day 28, respectively. The third immunization on Day 21 is a fairly high increase in specific antibodies against polysaccharide type 6B and type 19F. The highest antibody titers against polysaccharide capsules of S. pneumoniae were obtained after booster immunization.

Collaboration network of the authors

40 authors · 148 co-authorship links · showing the 40 most connected

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  • Hasanuddin University
  • Universitas Halu Oleo
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Yulia Rosa SaharmanAffiliation unknown2
Beti Ernawati DewiAffiliation unknown2
Anwar DaudAffiliation unknown2
Agus Bintara BirawidaAffiliation unknown2
Zaraswati DwyanaAffiliation unknown2
Eymal Bahsar DemmalinoHasanuddin University2
Wresti IndriatmiAffiliation unknown2
Yeva RosanaAffiliation unknown2
Ida EffendiAffiliation unknown2
Mardiastuti H WahidAffiliation unknown1
Ari Fahrial SyamAffiliation unknown1
Rike SyahniarAffiliation unknown1
Fithriyah FithriyahAffiliation unknown1
Pratiwi SudarmonoAffiliation unknown1
Anis KaruniawatiAffiliation unknown1
Fera IbrahimAffiliation unknown1
Augustine natashaAffiliation unknown1
Selvia GaniesaAffiliation unknown1
Dita AditianingsihAffiliation unknown1
Nina SaniaAffiliation unknown1
Delly Chipta LestariAffiliation unknown1
Samsuridjal DjauziAffiliation unknown1
Ikhwan RinaldiAffiliation unknown1
Rudi PutrantoAffiliation unknown1
Murdani AbdullahAffiliation unknown1
Alvina WidhaniAffiliation unknown1
Meutia GebrinaAffiliation unknown1
Franciscus Dhyanagiri SuyatnaAffiliation unknown1
Susan RahayuAffiliation unknown1
Amalia ShabrinaAffiliation unknown1
Dewi AnggrainiUniversitas Halu Oleo1
Indra YoviAffiliation unknown1
Nur Afrainin SyahAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://journal.ipb.ac.id/index.php/hayati/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">Immune Response to Capsular Polysaccharide of Streptococcus pneumoniae in Rabbits Immunized with Pneumococcal Conjugate Vaccine</dc:title>
	<dc:creator xml:lang="en">Zaenab</dc:creator>
	<dc:creator xml:lang="en">Tafroji, Wisnu </dc:creator>
	<dc:creator xml:lang="en">Salsabila, Korrie </dc:creator>
	<dc:creator xml:lang="en"> Winarti, Yayah</dc:creator>
	<dc:creator xml:lang="en">Wulandari, I Gusti Ayu Inten </dc:creator>
	<dc:creator xml:lang="en"> Yasmon, Andi</dc:creator>
	<dc:creator xml:lang="en">Safari, Dodi</dc:creator>
	<dc:description xml:lang="en">To evaluate the immune response of a rabbit model to polysaccharide capsules of Streptococcus pneumoniae after primary and booster immunization with pneumococcal conjugate vaccine. Rabbits were immunized with 0.25 ml of the 13-valent pneumococcal conjugate vaccine (PCV13) on Day 0, 7, and 14. Blood of rabbits was collected to measure the specific antibodies against the native polysaccharide capsules of S. pneumoniae serotypes 6B (Anti-Pn6BPS antibodies) and 19F (Anti-19FPS antibodies) using enzyme-linked immunosorbent assay (ELISA). The specific anti-Pn6BPS and anti-Pn19FPS antibodies in the immunized group increased significantly compared to the control rabbit after immunization (P&amp;lt;0.05). The highest titer of anti-Pn6BPS and anti-Pn19FPS antibodies were obtained on Day 21 and Day 28, respectively. The third immunization on Day 21 is a fairly high increase in specific antibodies against polysaccharide type 6B and type 19F. The highest antibody titers against polysaccharide capsules of S. pneumoniae were obtained after booster immunization.</dc:description>
	<dc:publisher xml:lang="en">Bogor Agricultural University, Indonesia</dc:publisher>
	<dc:date>2025-01-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://journal.ipb.ac.id/hayati/article/view/51033</dc:identifier>
	<dc:identifier>10.4308/hjb.32.3.642-648</dc:identifier>
	<dc:source xml:lang="en">HAYATI Journal of Biosciences; Vol. 32 No. 3 (2025): May 2025; 642-648</dc:source>
	<dc:source>2086-4094</dc:source>
	<dc:source>1978-3019</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://journal.ipb.ac.id/hayati/article/view/51033/30057</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Zaenab , Wisnu  Tafroji, Korrie  Salsabila, Yayah  Winarti, I Gusti Ayu Inten  Wulandari, Andi  Yasmon, Dodi Safari</dc:rights>
</oai_dc:dc>