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Role of LAVi/A’ and E/’ as A Predictor of Major Adverse Cardiac Event on Patient with Acute Myocardial Infraction with ST Segment Elevation Undergo Through Percutaneous Coronary Intervention

Heart Science Journal · Vol. 2 No. 1 (2021) · pp. 30–35

DOI
10.21776/ub.hsj.2021.002.01.05
ISSN
2721-9984, 2721-9976
Published
2021-02-28
Publisher
Universitas Brawijaya
Language
en

Abstract

Introduction:STEMI is still a major health problem in industrialized and developing countries. The risk of adverse cardiovascular events remains substansial and may vary significantly across of STEMI patients. Echocardiography is recommended tool for diagnosis and predict outcomes. Increased LA volume index (LAVI) has been shown to be a powerfull predictor of mortality after AMI. The ratio of the  left atrial volume index (LAVI) and late diastolic mitral annular velocity (A’) is additional benefits in the assessment od advance diastolic dysfunction in ACS for predicting outcome.Methods:This study retrospective cohort was conducted in patient admitted to Saiful Anawar General Hospital with STEMI who undergo PCI from 2019-2020. All patient underwent echocardiography measurement within 24-48 hours and we follow-up patient for 6 months until 12 months. Echocardiography measurement that we conducted were LVEF, E/A, E/e’, LAVI/A’ and LV diastolic function were measured according to ASE guidelines. All of the patients were given standard medical therapy. Patients who did not adhere to medication were excluded. The study endpoints were hospitalisation and mortality because of cardiac problem. Result:We collected the data from 169 STEMI patients. However, about 39 STEMI patients were excluded because of incomplete data, lost follow-up, become atrial fibrillation, refused participation and death. Finally, a total of 130 patients were involved in the analysis process. The patients mean age was 61.48 ± 7 years, and 78% of them were male. The receiver operating characteristics curve indicated that LAVI/A’ ≥ 4.0 predicted these events (AUC 0.892, 95% CI 0.819-0.965) and E/e’  ≥ was 13.4 (AUC 0.874, 95% CI; 0.806-0.942). The MACE incident in 6 months with LAVI/A’ ≥ 4.0 was 40%, E/e’ ≥ 13.4 was 20% and LAVI/A’ ≥ 4.0 + E/e’ ≥ 13.4 was higher 60%. The incidence MACE incident was LAVI/A’ > 4.0 sensitivity 92% and specifity 88% (CI 95%), E/e’ > 13.4 sensitivity 80% and specifity 74% (CI 95%), LAVI/A’ > 4.0 + E/e’ > 13.4 sensitivity 92% and specifity 88% (CI 95%). Conlussion:The LAVI/A’ ratio is available as echo index which reflects LV chronic diastolic function in patient with STEMI. It can predict MACE, particularly in those with STEMI undergo PCI. Combined LAVI/A’ > 4.0 and E/e’ >13,4 ratio suggests MACE better than LAVI/A’ > 4.0 and E/e’ >13,4 alone.Keywords: ST-elevation Myocardial Infarction, Echocardiography, LAVI/A’, E/e’, Percutaneous Coronary Intervention

Keywords

Collaboration network of the authors

40 authors · 285 co-authorship links · showing the 40 most connected

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  • University of Brawijaya
  • Affiliation unknown
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Co-authorOrganisationJoint articles
Mohammad Saifur RohmanAffiliation unknown62
Novi KurnianingsihAffiliation unknown36
Setyasih AnjarwaniAffiliation unknown30
Ardian RizalAffiliation unknown26
Indra PrasetyaAffiliation unknown26
Heny MartiniAffiliation unknown24
Sasmojo WiditoAffiliation unknown24
Yoga WaranugrahaAffiliation unknown10
Wella KarolinaAffiliation unknown9
Valerinna YogibuanaAffiliation unknown8
Muhammad Rizki FadlanAffiliation unknown7
Teguh AryanugrahaAffiliation unknown7
Saskia Dyah HandariAffiliation unknown6
Ayu Asri Devi AdityawatiAffiliation unknown6
Nikhen NoverikeAffiliation unknown5
Imelda KrisnasariAffiliation unknown5
Lukitasari Ayu GaluhAffiliation unknown5
Putri Annisa KamilaUniversity of Brawijaya5
Dadang HendrawanAffiliation unknown5
Lutfi Hafiz ZunardiAffiliation unknown4
Olivia HandayaniAffiliation unknown4
Liemena Harold AdrianAffiliation unknown4
Dea Arie KurniawanAffiliation unknown3
Arif WicaksonoAffiliation unknown3
Tri AstiawatiAffiliation unknown3
Valerinna Yogibuana Swastika PutriAffiliation unknown3
Zainal FathurohimAffiliation unknown3
Dedy IrawanAffiliation unknown3
Imam Mi'raj SuprayogaAffiliation unknown3
Veny KurniawatiAffiliation unknown2
Tonny AdriyantoAffiliation unknown2
Anita Surya SantosoAffiliation unknown2
Oktafin Srywati PamunaAffiliation unknown2
Ratna PancasariAffiliation unknown2

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://heartscience.ub.ac.id/index.php/heartscience/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Role of LAVi/A’ and E/’ as A Predictor of Major Adverse Cardiac Event on Patient with Acute Myocardial Infraction with ST Segment Elevation Undergo Through Percutaneous  Coronary Intervention</dc:title>
	<dc:creator xml:lang="en">Pratama, Aditya Reza</dc:creator>
	<dc:creator xml:lang="en">Satrijo, Budi</dc:creator>
	<dc:creator xml:lang="en">Rahimah, Anna Fuji</dc:creator>
	<dc:creator xml:lang="en">Sargowo, Djanggan</dc:creator>
	<dc:creator xml:lang="en">Tjahjono, Cholid Tri</dc:creator>
	<dc:creator xml:lang="en">Fadlan, Muhammad Rizki Rizki</dc:creator>
	<dc:subject xml:lang="en">ST-elevation Myocardial Infarction</dc:subject>
	<dc:subject xml:lang="en">Echocardiography</dc:subject>
	<dc:subject xml:lang="en">LAVI/A’</dc:subject>
	<dc:subject xml:lang="en">E/e’</dc:subject>
	<dc:subject xml:lang="en">Percutaneous Coronary Intervention</dc:subject>
	<dc:description xml:lang="en">Introduction:STEMI is still a major health problem in industrialized and developing countries. The risk of adverse cardiovascular events remains substansial and may vary significantly across of STEMI patients. Echocardiography is recommended tool for diagnosis and predict outcomes. Increased LA volume index (LAVI) has been shown to be a powerfull predictor of mortality after AMI. The ratio of the  left atrial volume index (LAVI) and late diastolic mitral annular velocity (A’) is additional benefits in the assessment od advance diastolic dysfunction in ACS for predicting outcome.Methods:This study retrospective cohort was conducted in patient admitted to Saiful Anawar General Hospital with STEMI who undergo PCI from 2019-2020. All patient underwent echocardiography measurement within 24-48 hours and we follow-up patient for 6 months until 12 months. Echocardiography measurement that we conducted were LVEF, E/A, E/e’, LAVI/A’ and LV diastolic function were measured according to ASE guidelines. All of the patients were given standard medical therapy. Patients who did not adhere to medication were excluded. The study endpoints were hospitalisation and mortality because of cardiac problem. Result:We collected the data from 169 STEMI patients. However, about 39 STEMI patients were excluded because of incomplete data, lost follow-up, become atrial fibrillation, refused participation and death. Finally, a total of 130 patients were involved in the analysis process. The patients mean age was 61.48 ± 7 years, and 78% of them were male. The receiver operating characteristics curve indicated that LAVI/A’ ≥ 4.0 predicted these events (AUC 0.892, 95% CI 0.819-0.965) and E/e’  ≥ was 13.4 (AUC 0.874, 95% CI; 0.806-0.942). The MACE incident in 6 months with LAVI/A’ ≥ 4.0 was 40%, E/e’ ≥ 13.4 was 20% and LAVI/A’ ≥ 4.0 + E/e’ ≥ 13.4 was higher 60%. The incidence MACE incident was LAVI/A’ &amp;gt; 4.0 sensitivity 92% and specifity 88% (CI 95%), E/e’ &amp;gt; 13.4 sensitivity 80% and specifity 74% (CI 95%), LAVI/A’ &amp;gt; 4.0 + E/e’ &amp;gt; 13.4 sensitivity 92% and specifity 88% (CI 95%). Conlussion:The LAVI/A’ ratio is available as echo index which reflects LV chronic diastolic function in patient with STEMI. It can predict MACE, particularly in those with STEMI undergo PCI. Combined LAVI/A’ &amp;gt; 4.0 and E/e’ &amp;gt;13,4 ratio suggests MACE better than LAVI/A’ &amp;gt; 4.0 and E/e’ &amp;gt;13,4 alone.Keywords: ST-elevation Myocardial Infarction, Echocardiography, LAVI/A’, E/e’, Percutaneous Coronary Intervention</dc:description>
	<dc:publisher xml:lang="en">Universitas Brawijaya</dc:publisher>
	<dc:date>2021-02-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://heartscience.ub.ac.id/index.php/heartscience/article/view/151</dc:identifier>
	<dc:identifier>10.21776/ub.hsj.2021.002.01.05</dc:identifier>
	<dc:source xml:lang="en">Heart Science Journal; Vol. 2 No. 1 (2021): How to Diagnose Heart Failure and Deal with The Treatment Complexity; 30-35</dc:source>
	<dc:source>2721-9984</dc:source>
	<dc:source>2721-9976</dc:source>
	<dc:source>10.21776/ub.hsj.2021.002.01</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://heartscience.ub.ac.id/index.php/heartscience/article/view/151/301</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2021 Aditya Reza Pratama, Budi Satrijo, Anna Fuji Rahimah, Djanggan Sargowo, Cholid Tri Tjahjono, Muhammad Rizki Rizki Fadlan</dc:rights>
</oai_dc:dc>