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Impact of Strict and Lenient Heart Rate Control on Six-Minute Walk Test and Quality of Life in Atrial-Fibrillation Patients with Rheumatic Mitral Stenosis: Randomized Control Trial

Heart Science Journal · Vol. 5 No. 2 (2024) · pp. 44–50

DOI
10.21776/ub/hsj.2024.005.02.8
ISSN
2721-9984, 2721-9976
Published
2024-04-28
Publisher
Universitas Brawijaya
Language
en

Abstract

Background: Recent studies showed no outcome difference between strict and lenient rate control in the general Atrial Fibrillation (AF) population. However, for AF and Rheumatic Mitral Stenosis (RMS) patients, evidences were lacking.Objective: To assess the impact of strict and lenient heart rate control on the Six-Minute Walk Test (SMWT) and Health Related Quality of Life (HRQoL) in patients with AF and RMS.Material and Methods: A prospective multicenter trial across tertiary hospitals in East Java assessed strict and lenient heart rate control's impact on the SMWT and HRQoL in AF and RMS patients. Sixty-one participants were randomized into strict and lenient groups over six months from March to August 2023. Medications were adjusted to achieve target heart rates, and HRQoL was assessed using SF-36 and SMWT at baseline and three months post-target heart rate attainment.Result: In our study, 29 patients were under strict heart rate control, and 32 were under lenient control. We found a decrease in HRQoL across all subscales, with significant differences observed in general health perception and physical function among those under strict control (p=0.002 and 0.03, respectively). However, no significant disparity was found in the SMWT distance difference between lenient and strict groups (p=0.529), nor in METs (p=0.326).Conclusion: In the study, lenient heart rate control demonstrates significant effects on the general health perception and physical function subscales compared to strict heart rate control.Â

Keywords

Collaboration network of the authors

40 authors · 277 co-authorship links · showing the 40 most connected

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  • University of Brawijaya
  • Affiliation unknown
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Co-authorOrganisationJoint articles
Indra PrasetyaAffiliation unknown39
Setyasih AnjarwaniAffiliation unknown37
Cholid Tri TjahjonoAffiliation unknown36
Novi KurnianingsihAffiliation unknown35
Budi SatrijoAffiliation unknown31
Heny MartiniAffiliation unknown31
Djanggan SargowoAffiliation unknown28
Sasmojo WiditoAffiliation unknown26
Wella KarolinaAffiliation unknown16
Valerinna YogibuanaAffiliation unknown10
Nikhen NoverikeAffiliation unknown8
Dadang HendrawanAffiliation unknown6
Muhammad Rizki FadlanAffiliation unknown6
Imelda KrisnasariAffiliation unknown5
Icmi Dian RochmawatiAffiliation unknown5
Olivia HandayaniAffiliation unknown5
Fahmy RusnantaAffiliation unknown5
Hayla Iqda MillisaniAffiliation unknown4
Lukitasari Ayu GaluhAffiliation unknown4
Puspa LestariAffiliation unknown4
Putri Annisa KamilaUniversity of Brawijaya4
Anita Surya SantosoAffiliation unknown4
Ayu Asri Devi AdityawatiAffiliation unknown4
Oktafin Srywati PamunaAffiliation unknown4
Seprian WidasmaraAffiliation unknown4
Cik KahadiAffiliation unknown4
Lutfi Hafiz ZunardiAffiliation unknown3
Mokhamad Aswin BaharAffiliation unknown3
Zhafran VeliawanAffiliation unknown3
Dion SetiawanAffiliation unknown3
Indra Jabbar AzizAffiliation unknown3

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://heartscience.ub.ac.id/index.php/heartscience/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Impact of Strict and Lenient Heart Rate Control on Six-Minute Walk Test and Quality of Life in Atrial-Fibrillation Patients with Rheumatic Mitral Stenosis : Randomized Control Trial</dc:title>
	<dc:creator xml:lang="en">Dwigustiningrum, Nur Kaputrin</dc:creator>
	<dc:creator xml:lang="en">Rizal, Ardian</dc:creator>
	<dc:creator xml:lang="en">Putri, Valerinna Yogibuana Swastika</dc:creator>
	<dc:creator xml:lang="en">Rahimah, Anna Fuji</dc:creator>
	<dc:creator xml:lang="en">Rohman, Mohammad Saifur</dc:creator>
	<dc:creator xml:lang="en">Wikananda, Adhika Prastya</dc:creator>
	<dc:creator xml:lang="en">Waranugraha, Yoga</dc:creator>
	<dc:creator xml:lang="en">Astiawati, Tri</dc:creator>
	<dc:creator xml:lang="en">Laitupa, Fitranti Suciati</dc:creator>
	<dc:subject xml:lang="en">Strict and Lenient heart rate</dc:subject>
	<dc:subject xml:lang="en">HRQoL</dc:subject>
	<dc:subject xml:lang="en">Six-Minute Walk Test</dc:subject>
	<dc:subject xml:lang="en">Atrial Fibrillation</dc:subject>
	<dc:subject xml:lang="en">Rheumatic Mitral Stenosis</dc:subject>
	<dc:description xml:lang="en">Background: Recent studies showed no outcome difference between strict and lenient rate control in the general Atrial Fibrillation (AF) population. However, for AF and Rheumatic Mitral Stenosis (RMS) patients, evidences were lacking.Objective: To assess the impact of strict and lenient heart rate control on the Six-Minute Walk Test (SMWT) and Health Related Quality of Life (HRQoL) in patients with AF and RMS.Material and Methods: A prospective multicenter trial across tertiary hospitals in East Java assessed strict and lenient heart rate control's impact on the SMWT and HRQoL in AF and RMS patients. Sixty-one participants were randomized into strict and lenient groups over six months from March to August 2023. Medications were adjusted to achieve target heart rates, and HRQoL was assessed using SF-36 and SMWT at baseline and three months post-target heart rate attainment.Result: In our study, 29 patients were under strict heart rate control, and 32 were under lenient control. We found a decrease in HRQoL across all subscales, with significant differences observed in general health perception and physical function among those under strict control (p=0.002 and 0.03, respectively). However, no significant disparity was found in the SMWT distance difference between lenient and strict groups (p=0.529), nor in METs (p=0.326).Conclusion: In the study, lenient heart rate control demonstrates significant effects on the general health perception and physical function subscales compared to strict heart rate control. </dc:description>
	<dc:publisher xml:lang="en">Universitas Brawijaya</dc:publisher>
	<dc:date>2024-04-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://heartscience.ub.ac.id/index.php/heartscience/article/view/15766</dc:identifier>
	<dc:identifier>10.21776/ub/hsj.2024.005.02.8</dc:identifier>
	<dc:source xml:lang="en">Heart Science Journal; Vol. 5 No. 2 (2024): Challenges in the Management of Congenital Heart and Structural Heart Diseases; 44-50</dc:source>
	<dc:source>2721-9984</dc:source>
	<dc:source>2721-9976</dc:source>
	<dc:source>10.21776/ub.hsj.2024.005.02</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://heartscience.ub.ac.id/index.php/heartscience/article/view/15766/404</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Nur Kaputrin</dc:rights>
</oai_dc:dc>