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Molecular mechanisms of vascular calcification in diabetes mellitus: insights from human aortic smooth muscle cells, a systematic review

Heart Science Journal · Vol. 7 No. 1 (2026) · pp. 4–10

DOI
10.21776/ub.hsj.2026.007.01.2
ISSN
2721-9984, 2721-9976
Published
2026-01-31
Publisher
Universitas Brawijaya
Language
en
License
creativecommons.org/licenses/by/4.0

Abstract

Background: Vascular calcification is a significant contributor to cardiovascular complications in diabetes mellitus (DM), particularly affecting the prognosis of patients. Objectives: To conduct a comprehensive analysis of the molecular mechanisms underlying vascular calcification in DM, with a focus on insights from human aortic smooth muscle cells (HASMCs). Methods: The search was conducted following the PRISMA guidelines, utilizing databases such as MEDLINE/PubMed, Science Direct, and Google Scholar. The search focused on articles published within the last 5 years that discussed the molecular mechanisms of vascular calcification in DM, specifically in HASMCs. Results: Five selected reviews were found in a total of 637 articles. DM significantly accelerates vascular calcification in HASMCs through the upregulation of osteogenic markers and activation of the Wnt/β-catenin signaling pathway. Other identified mechanisms include inflammation, ferroptosis, and endothelial dysfunction, contributing to the complex interplay of factors that drive vascular calcification in diabetic patients. Conclusion: It is concluded that DM significantly accelerates vascular calcification in enhanced expression of osteogenic markers and activation of the Wnt/β-catenin signaling pathway in human aortic smooth muscle cells. Patients with diabetes are more likely to have cardiovascular issues as a result of this pathological process.

Keywords

Collaboration network of the authors

40 authors · 242 co-authorship links · showing the 40 most connected

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  • University of Brawijaya
  • Affiliation unknown
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  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Ardian RizalAffiliation unknown19
Anna Fuji RahimahAffiliation unknown19
Budi SatrijoAffiliation unknown17
Indra PrasetyaAffiliation unknown17
Cholid Tri TjahjonoAffiliation unknown17
Setyasih AnjarwaniAffiliation unknown15
Novi KurnianingsihAffiliation unknown12
Yoga WaranugrahaAffiliation unknown10
Djanggan SargowoAffiliation unknown9
Sasmojo WiditoAffiliation unknown9
Heny MartiniAffiliation unknown9
Adhika Prastya WikanandaAffiliation unknown4
Valerinna YogibuanaAffiliation unknown4
Tri AstiawatiAffiliation unknown4
Tri Yudani Mardining RarasAffiliation unknown4
Dadang HendrawanAffiliation unknown3
Muhammad Rizki FadlanAffiliation unknown3
Wella KarolinaAffiliation unknown3
Hayla Iqda MillisaniAffiliation unknown3
Retty RatnawatiAffiliation unknown3
Jonny Karunia FajarAffiliation unknown3
Veny KurniawatiAffiliation unknown2
Putri Annisa KamilaUniversity of Brawijaya2
Tonny AdriyantoAffiliation unknown2
Olivia HandayaniAffiliation unknown2
Fahmy RusnantaAffiliation unknown2
Anita Surya SantosoAffiliation unknown2
Fitranti Suciati LaitupaAffiliation unknown2
Oktafin Srywati PamunaAffiliation unknown2
Imelda KrisnasariAffiliation unknown2
Setyawati SoehartoUniversity of Brawijaya2
Hidayat SujutiAffiliation unknown2

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://heartscience.ub.ac.id/index.php/heartscience/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Molecular mechanisms of vascular calcification in diabetes mellitus: insights from human aortic smooth muscle cells, a systematic review</dc:title>
	<dc:creator xml:lang="en">Weningtyas, Anditri</dc:creator>
	<dc:creator xml:lang="en">Rohman, Mohammad Saifur</dc:creator>
	<dc:creator xml:lang="en">Chomsy, Indah Nur</dc:creator>
	<dc:creator xml:lang="en">Hose, Victor Alvianoes Guterez</dc:creator>
	<dc:creator xml:lang="en">Riza, Mochamad Faishal</dc:creator>
	<dc:creator xml:lang="en">Purbaningroom, Dian Laila</dc:creator>
	<dc:creator xml:lang="en">Rudijanto, Achmad</dc:creator>
	<dc:creator xml:lang="en">Nugrahenny, Dian</dc:creator>
	<dc:subject xml:lang="en">Aortic Smooth Muscle</dc:subject>
	<dc:subject xml:lang="en">Diabetes Mellitus</dc:subject>
	<dc:subject xml:lang="en">Molecular Mechanism</dc:subject>
	<dc:subject xml:lang="en">Vascular Calcification</dc:subject>
	<dc:description xml:lang="en">Background: Vascular calcification is a significant contributor to cardiovascular complications in diabetes mellitus (DM), particularly affecting the prognosis of patients.  
Objectives: To conduct a comprehensive analysis of the molecular mechanisms underlying vascular calcification in DM, with a focus on insights from human aortic smooth muscle cells (HASMCs).
Methods: The search was conducted following the PRISMA guidelines, utilizing databases such as MEDLINE/PubMed, Science Direct, and Google Scholar. The search focused on articles published within the last 5 years that discussed the molecular mechanisms of vascular calcification in DM, specifically in HASMCs.
Results: Five selected reviews were found in a total of 637 articles. DM significantly accelerates vascular calcification in HASMCs through the upregulation of osteogenic markers and activation of the Wnt/β-catenin signaling pathway. Other identified mechanisms include inflammation, ferroptosis, and endothelial dysfunction, contributing to the complex interplay of factors that drive vascular calcification in diabetic patients.
Conclusion: It is concluded that DM significantly accelerates vascular calcification in enhanced expression of osteogenic markers and activation of the Wnt/β-catenin signaling pathway in human aortic smooth muscle cells. Patients with diabetes are more likely to have cardiovascular issues as a result of this pathological process.</dc:description>
	<dc:publisher xml:lang="en">Universitas Brawijaya</dc:publisher>
	<dc:date>2026-01-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://heartscience.ub.ac.id/index.php/heartscience/article/view/20224</dc:identifier>
	<dc:identifier>10.21776/ub.hsj.2026.007.01.2</dc:identifier>
	<dc:source xml:lang="en">Heart Science Journal; Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Patient Care; 4-10</dc:source>
	<dc:source>2721-9984</dc:source>
	<dc:source>2721-9976</dc:source>
	<dc:source>10.21776/ub.hsj.2026.007.01</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://heartscience.ub.ac.id/index.php/heartscience/article/view/20224/551</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Anditri Weningtyas, Mohammad Saifur Rohman, Indah Nur Chomsy, Victor Alvianoes Guterez Hose, Mochamad Faishal Riza, Dian Laila Purbaningroom, Achmad Rudijanto, Dian Nugrahenny</dc:rights>
	<dc:rights xml:lang="en">http://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>