Melola Discovery

← Melola Discovery

Journal SINTA 1

Apolipoprotein E as Risk Factor for Coronary Heart Disease

Indonesian Journal of Biotechnology · Vol. 18 No. 1 (2013) · pp. 42–51

DOI
10.22146/ijbiotech.7867
ISSN
2089-2241, 0853-8654
Published
2013-06-09
Publisher
Universitas Gadjah Mada
Language
eng

Abstract

Allelic variation of apolipoprotein E (apo E) has been shown to infl uence the concentrations of total cholesterol and low density lipoprotein cholesterol (LDL-C) and considered to play a role as one of risk factors for coronary heart disease (CHD). The aim of this study was to examine the relationship between Apo E polymorphism and the risk of CHD. Blood samples were collected from 33 CHD patients in Dr. Sardjito Hospital Yogyakarta, and 38 apparently healthy control individuals in a cross sectional study. The common allelic variants of ApoE were screened employing polymerase chain reaction and restriction fragment length polymorphism. The results obtained were analyzed by t-test and signifi cantly different if p <0.05 and risk factor was calculated by odd ratio. Frequency of ApoE ε2, ε2 and ε4 alleles in CHD patients were 12.1%, 69.7% and 18.2% while in controls were 18.4%, 72.4% and 9.2% respectively. Dyslipidemia condition was a strongrisk factor for CHD. By controlling lipid profi le and applying multifactorial statistic analysis, it was shown that ε4 gene carrier was the risk factor for CHD, but not in triglyceride level, whereas ε2 carrier gene was not the risk factor for CHD. Dislipidemia was the risk factor for CHD and ApoE ε4 gene carrier was the risk factor for CHD. Key words: apolipoprotein E, ApoE ε4 gene carrier, coronary heart disease, dyslipidemia.

Keywords

Collaboration network of the authors

27 authors · 57 co-authorship links

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • Universitas Gadjah Mada
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Abdul Salam Mudzakir SofroAffiliation unknown3
S SunartiAffiliation unknown2
Agustina Welhelmina DjumaAffiliation unknown1
Chusnul HidayatAffiliation unknown1
Indro PrastowoAffiliation unknown1
Djaswadi DasukiAffiliation unknown1
Totok UtoroAffiliation unknown1
Pinda HutajuluAffiliation unknown1
Indwiani AstutiAffiliation unknown1
Waode Astria SahraniAffiliation unknown1
Wasilah RochmahAffiliation unknown1
Nyoman KertiaAffiliation unknown1
M. MarsetyawanAffiliation unknown1
Putri Widelia WelkrianaAffiliation unknown1
Ani KristiyaniAffiliation unknown1
Dwi Aris Agung NugrahaningsihUniversitas Gadjah Mada1
Sarah AtmajaAffiliation unknown1
Ellsya Angeline RawarAffiliation unknown1
Christine PatramurtiAffiliation unknown1
Saryono SaryonoAffiliation unknown1
Wayan T. ArtamaAffiliation unknown1
Rochadi RochadiAffiliation unknown1
Wiryatun LestarianaAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://jurnal.ugm.ac.id/ijbiotech/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Apolipoprotein E as Risk Factor for Coronary Heart Disease</dc:title>
	<dc:creator>Hastuti, Pramudji</dc:creator>
	<dc:creator>Sofro, Abdul Salam M.</dc:creator>
	<dc:creator>Asdie, Ahmad Husain</dc:creator>
	<dc:creator>Sadewa, Ahmad Hamim</dc:creator>
	<dc:subject xml:lang="en-US">apolipoprotein E; ApoE ε4 gene carrier; Coronary Heart Disease; Dyslipidemia</dc:subject>
	<dc:description xml:lang="en-US">Allelic variation of apolipoprotein E (apo E) has been shown to infl uence the concentrations of total cholesterol and low density lipoprotein cholesterol (LDL-C) and considered to play a role as one of risk factors for coronary heart disease (CHD). The aim of this study was to examine the relationship between Apo E polymorphism and the risk of CHD. Blood samples were collected from 33 CHD patients in Dr. Sardjito Hospital Yogyakarta, and 38 apparently healthy control individuals in a cross sectional study. The common allelic variants of ApoE were screened employing polymerase chain reaction and restriction fragment length polymorphism. The results obtained were analyzed by t-test and signifi cantly different if p &lt;0.05 and risk factor was calculated by odd ratio. Frequency of ApoE ε2, ε2 and ε4 alleles in CHD patients were 12.1%, 69.7% and 18.2% while in controls were 18.4%, 72.4% and 9.2% respectively. Dyslipidemia condition was a strongrisk factor for CHD. By controlling lipid profi le and applying multifactorial statistic analysis, it was shown that ε4 gene carrier was the risk factor for CHD, but not in triglyceride level, whereas ε2 carrier gene was not the risk factor for CHD. Dislipidemia was the risk factor for CHD and ApoE ε4 gene carrier was the risk factor for CHD. Key words: apolipoprotein E, ApoE ε4 gene carrier, coronary heart disease, dyslipidemia.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Gadjah Mada</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2013-06-09</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Original Research Articles</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ugm.ac.id/ijbiotech/article/view/7867</dc:identifier>
	<dc:identifier>10.22146/ijbiotech.7867</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Biotechnology; Vol 18, No 1 (2013); 42-51</dc:source>
	<dc:source>2089-2241</dc:source>
	<dc:source>0853-8654</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/view/7867/6108</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2015 Indonesian Journal of Biotechnology</dc:rights>
</oai_dc:dc>