Melola Discovery

← Melola Discovery

Open access Journal SINTA 1

Anti-metastatic effect of curcumin analog pentagamaboronon-0-fructose (PGB-0-F) against 4T1 breast cancer cells

Indonesian Journal of Biotechnology · Vol. 23 No. 2 (2018) · pp. 109–113

DOI
10.22146/ijbiotech.36431
ISSN
2089-2241, 0853-8654
Published
2018-12-24
Publisher
Universitas Gadjah Mada
Language
eng
License
creativecommons.org/licenses/by-sa/4.0

Abstract

Development of a chemotherapeutic agent and boron carrying pharmaceutical based on triple-negative breast cancer is important due to its metastatic progression. Metastases are often more dangerous than the primary tumor and they are responsible for 90% of all cancer deaths. The purpose of this study was to explore the anti-metastatic activities of the PGB-0 complex with fructose (PGB-0-F) against 4T1 breast cancer cells. A scratch wound healing assay was carried out to determine the migration inhibition ability of PGB-0-F, while MMP-9 expression was analysed using gelatin zymography. The testing of anti-migration activity showed that PGB-0-F inhibited in 4T1 cells, whereas the gelatin zymography assay revealed a suppression of MMP-9 expression. PGB-0-F inhibited closure on 4T1 metastatic breast cancer cells line compared with the control. PGB-0-F decreased the MMP-9 expression level compared with the control. Based on these results, PGB-0-F has the potential to be developed as a chemotherapeutic agent, and especially as an anti-metastatic agent.

Keywords

Collaboration network of the authors

40 authors · 139 co-authorship links · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • University of Brawijaya
  • IPB University
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Adam HermawanAffiliation unknown27
Muthi’ IkawatiAffiliation unknown16
Sri HandayaniUniversity of Brawijaya13
Dyaningtyas Dewi Pamungkas PutriAffiliation unknown8
Dhania NovitasariAffiliation unknown6
Faaza Aulia RahmanAffiliation unknown6
Desty Restia RahmawatiAffiliation unknown6
Annisa NovarinaAffiliation unknown6
Zalinar UdinAffiliation unknown6
Sari HaryantiAffiliation unknown5
Retno MurwantiAffiliation unknown5
Larasati LarasatiIPB University5
Ummi Maryam ZulfinAffiliation unknown4
Lailatul QodriaAffiliation unknown4
Hilyatul FadliyahAffiliation unknown4
Indri KusharyantiAffiliation unknown4
Nindya Budiana PutriAffiliation unknown4
Raisatun Nisa SugiyantoAffiliation unknown4
Anindyajati AnindyajatiAffiliation unknown3
Erlina RivantiAffiliation unknown3
Sendy JunediAffiliation unknown3
Gergorius Gena MaranAffiliation unknown3
Aulia Nur SeptianiAffiliation unknown3
Sofa FaridaAffiliation unknown3
Beni LestariAffiliation unknown3
Laeli MuntafiahAffiliation unknown3
Bani Adlina ShabrinaAffiliation unknown3
Rumiyati RumiyatiAffiliation unknown3
Masashi KawaichiAffiliation unknown2
Nunuk Aries NurulitaAffiliation unknown2
Suwijiyo PramonoAffiliation unknown2
Laili Nailul MunaAffiliation unknown2
Asri Mega PutriAffiliation unknown2
Nur Fitra SariAffiliation unknown2
Fatiha Citra EffendiAffiliation unknown2

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://jurnal.ugm.ac.id/ijbiotech/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Anti-metastatic effect of curcumin analog pentagamaboronon-0-fructose (PGB-0-F) against 4T1 breast cancer cells</dc:title>
	<dc:creator>Ertanto, Yogi</dc:creator>
	<dc:creator>Utomo, Rohmad Yudi</dc:creator>
	<dc:creator>Jenie, Riris Istighfari</dc:creator>
	<dc:creator>Susidarti, Ratna Asmah</dc:creator>
	<dc:creator>Meiyanto, Edy</dc:creator>
	<dc:subject xml:lang="en-US">curcumin analogue, PGB-0-F, 4T1 Cells, migration, MMP-9</dc:subject>
	<dc:description xml:lang="en-US">Development of a chemotherapeutic agent and boron carrying pharmaceutical based on triple-negative breast cancer is important due to its metastatic progression. Metastases are often more dangerous than the primary tumor and they are responsible for 90% of all cancer deaths. The purpose of this study was to explore the anti-metastatic activities of the PGB-0 complex with fructose (PGB-0-F) against 4T1 breast cancer cells. A scratch wound healing assay was carried out to determine the migration inhibition ability of PGB-0-F, while MMP-9 expression was analysed using gelatin zymography. The testing of anti-migration activity showed that PGB-0-F inhibited in 4T1 cells, whereas the gelatin zymography assay revealed a suppression of MMP-9 expression. PGB-0-F inhibited closure on 4T1 metastatic breast cancer cells line compared with the control. PGB-0-F decreased the MMP-9 expression level compared with the control. Based on these results, PGB-0-F has the potential to be developed as a chemotherapeutic agent, and especially as an anti-metastatic agent.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Gadjah Mada</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2018-12-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Original Research Articles</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ugm.ac.id/ijbiotech/article/view/36431</dc:identifier>
	<dc:identifier>10.22146/ijbiotech.36431</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Biotechnology; Vol 23, No 2 (2018); 109-113</dc:source>
	<dc:source>2089-2241</dc:source>
	<dc:source>0853-8654</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/view/36431/23820</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/36431/6561</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/36431/6562</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/36431/6563</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/ijbiotech/article/downloadSuppFile/36431/6605</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 The Author(s)</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>