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Antiproliferative Effect and Apoptosis Induced in Human Cell Lines by Bruguiera gymnorhiza Barks Methanol Extract

Indonesian Journal of Cancer Chemoprevention · Vol. 2 No. 3 (2011) · pp. 299–303

DOI
10.14499/indonesianjcanchemoprev2iss3pp299-303
ISSN
2355-8989, 2088-0197
Published
2011-10-31
Publisher
Indonesian Society for Cancer Chemoprevention
Language
eng

Abstract

The Antiproliferative effects of methanol extract from Bruguiera gymnorhiza (B. gymnorhiza) barks were tested in vitro against three human cell lines: Hela, Raji and Myeloma cells. The extract was found to have antiproliferative effects against Hela, Raji and Myeloma cells with an IC50 value of 133, 504 and 384 µg/mL, respectively. The antiproliferative test was then performed on Hela, Raji, and Myeloma cells. Cytotoxicity assay of the extract was then determined using MTT method. There were some indications of apoptosis, such DNA fragmentation, as assessed by acrydine orange- ethidium bromide staining. These results indicate that extract from B. gymnorhiza barks can induce apoptosis in human cell lines.Keywords: Antiproliferative, Apoptosis, B. gymnorhiza

Collaboration network of the authors

40 authors · 123 co-authorship links · showing the 40 most connected

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  • University of Brawijaya
  • IPB University
  • Cenderawasih University
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Edy MeiyantoAffiliation unknown13
Riris Istighfari JenieAffiliation unknown4
Adam HermawanAffiliation unknown3
Sri HandayaniUniversity of Brawijaya2
Desty Restia RahmawatiAffiliation unknown2
Larasati LarasatiIPB University2
Indri KusharyantiAffiliation unknown2
Ni Putu Linda LaksmianiAffiliation unknown2
Aditya Krishar KarimCenderawasih University1
Triyadi Hendra WijayaAffiliation unknown1
Nuraeni EkowatiAffiliation unknown1
Akhmad DarmawanAffiliation unknown1
Puspa Dewi Narrij LotulungAffiliation unknown1
Zalinar UdinAffiliation unknown1
Yogi ErtantoAffiliation unknown1
Rohmad Yudi UtomoAffiliation unknown1
Rumiyati RumiyatiAffiliation unknown1
Endang SemiartiAffiliation unknown1
Sitarina WidyaraniAffiliation unknown1
Dewi Tika SariAffiliation unknown1
Brilliant Kharisma ApritadilaAffiliation unknown1
Anami RiastriAffiliation unknown1
Faaza Aulia RahmanAffiliation unknown1
Aulia Nur SeptianiAffiliation unknown1
Novia Permata HapsariAffiliation unknown1
Yuli WidiyastutiAffiliation unknown1
Endah RetnaningrumAffiliation unknown1
Rozana ZuhriAffiliation unknown1
Raisatun Nisa SugiyantoAffiliation unknown1
Rahmi KhamsitaAffiliation unknown1
Inna ArmandariAffiliation unknown1
Kartika Dyah PalupiAffiliation unknown1
Sofa FaridaAffiliation unknown1
Nur Fitra SariAffiliation unknown1
Layung Sekar Sih WikanthiAffiliation unknown1
Nindi WulandariAffiliation unknown1
Yuni Fajar EstiAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ijcc.chemoprev.org/index.php/ijcc/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Antiproliferative Effect and Apoptosis Induced in Human Cell Lines by Bruguiera gymnorhiza Barks Methanol Extract</dc:title>
	<dc:creator>Warsinah, Warsinah</dc:creator>
	<dc:creator>Sismindari, Sismindari</dc:creator>
	<dc:creator>Susidarti, Ratna Asmah</dc:creator>
	<dc:description xml:lang="en-US">The Antiproliferative effects of methanol extract from Bruguiera gymnorhiza (B. gymnorhiza) barks were tested in vitro against three human cell lines: Hela, Raji and Myeloma cells. The extract was found to have antiproliferative effects against Hela, Raji and Myeloma cells with an IC50 value of 133, 504 and 384 µg/mL, respectively. The antiproliferative test was then performed on Hela, Raji, and Myeloma cells. Cytotoxicity assay of the extract was then determined using MTT method. There were some indications of apoptosis, such DNA fragmentation, as assessed by acrydine orange- ethidium bromide staining. These results indicate that extract from B. gymnorhiza barks can induce apoptosis in human cell lines.Keywords: Antiproliferative, Apoptosis, B. gymnorhiza</dc:description>
	<dc:publisher xml:lang="en-US">Indonesian Society for Cancer Chemoprevention</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2011-10-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/47</dc:identifier>
	<dc:identifier>10.14499/indonesianjcanchemoprev2iss3pp299-303</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 2, No 3 (2011); 299-303</dc:source>
	<dc:source>2355-8989</dc:source>
	<dc:source>2088-0197</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/47/48</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2017 Indonesian Journal of Cancer Chemoprevention</dc:rights>
</oai_dc:dc>