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Combination of Curcuma (Curcuma xanthorriza Roxb) Rhizome Ethanolic Extract and Awar-Awar (Ficus septica Burm.F) Leaves Ethanolic Extract Increases Cisplatin Cytotoxicity on T47D Breast Cancer Cells through Cell Cycle Modulation

Indonesian Journal of Cancer Chemoprevention · Vol. 8 No. 3 (2017) · pp. 120–125

DOI
10.14499/indonesianjcanchemoprev8iss3pp120-125
ISSN
2355-8989, 2088-0197
Published
2017-10-31
Publisher
Indonesian Society for Cancer Chemoprevention
Language
eng

Abstract

Curcuma (Curcuma xanthorriza Roxb.) and Awar-awar ((Ficus septica Burm.f.) are well known to have anticancer potential especially for breast cancer with low toxicity. This study aims to examine the potential effect of the combination of Curcuma ethanolic extracts (CEE) and awar-awar leaves ethanolic extract (AEE) to increase the efficacy of cisplatin toward T47D breast cancer cells. The combination activity was done using 3 series of concentration, 1/3; 1/6 and 1/12 of IC50, to determine the combination index (CI) of cisplatin, CEE and AEE under MTT assay. The result showed that the combination of 2.5 µM, 5 µg/ml, 1 µg/ml concentrations of cisplatin, CEE and AEE respectively result in synergistic effect with CI values less than 1. The treatment exhibited the cell accumulation in S phase (27.7%) against T47D breast cancer cells confirmed through cell cycle examination by flow cytometry. These results provided the evidence that the CEE and the AEE can be developed as co-chemotherapeutic agents combined with cisplatin to improve the effectiveness of breast cancer treatment.Keywords: Curcuma xanthorriza Roxb., Ficus septica Burm.f., cisplatin, cell cycle

Collaboration network of the authors

40 authors · 130 co-authorship links · showing the 40 most connected

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  • University of Brawijaya
  • IPB University
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Ratna Asmah SusidartiAffiliation unknown23
Adam HermawanAffiliation unknown20
Muthi’ IkawatiAffiliation unknown13
Rohmad Yudi UtomoAffiliation unknown13
Sri HandayaniUniversity of Brawijaya9
Dyaningtyas Dewi Pamungkas PutriAffiliation unknown7
Dhania NovitasariAffiliation unknown6
Sari HaryantiAffiliation unknown5
Retno MurwantiAffiliation unknown4
Faaza Aulia RahmanAffiliation unknown4
Desty Restia RahmawatiAffiliation unknown4
Ummi Maryam ZulfinAffiliation unknown4
Annisa NovarinaAffiliation unknown4
Zalinar UdinAffiliation unknown4
Yogi ErtantoAffiliation unknown4
Hilyatul FadliyahAffiliation unknown4
Rumiyati RumiyatiAffiliation unknown4
Anindyajati AnindyajatiAffiliation unknown3
Larasati LarasatiIPB University3
Erlina RivantiAffiliation unknown3
Gergorius Gena MaranAffiliation unknown3
Laili Nailul MunaAffiliation unknown3
Beni LestariAffiliation unknown3
Laeli MuntafiahAffiliation unknown3
Masashi KawaichiAffiliation unknown2
Sendy JunediAffiliation unknown2
Nunuk Aries NurulitaAffiliation unknown2
Suwijiyo PramonoAffiliation unknown2
Lailatul QodriaAffiliation unknown2
Aulia Nur SeptianiAffiliation unknown2
Sofa FaridaAffiliation unknown2
Asri Mega PutriAffiliation unknown2
Bani Adlina ShabrinaAffiliation unknown2
Indri KusharyantiAffiliation unknown2
Yonika Arum LarasatiAffiliation unknown2
Argandita MeiftasariAffiliation unknown2
Raditya Prima IstiajiAffiliation unknown2

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ijcc.chemoprev.org/index.php/ijcc/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Combination of Curcuma (Curcuma xanthorriza Roxb) Rhizome Ethanolic Extract and Awar-Awar (Ficus septica Burm.F) Leaves Ethanolic Extract Increases Cisplatin Cytotoxicity on T47D Breast Cancer Cells through Cell Cycle Modulation</dc:title>
	<dc:creator>Hidayati, Devi Nisa</dc:creator>
	<dc:creator>Jenie, Riris Istighfari</dc:creator>
	<dc:creator>Meiyanto, Edy</dc:creator>
	<dc:description xml:lang="en-US">Curcuma (Curcuma xanthorriza Roxb.) and Awar-awar ((Ficus septica Burm.f.) are well known to have anticancer potential especially for breast cancer with low toxicity. This study aims to examine the potential effect of the combination of Curcuma ethanolic extracts (CEE) and awar-awar leaves ethanolic extract (AEE) to increase the efficacy of cisplatin toward T47D breast cancer cells. The combination activity was done using 3 series of concentration, 1/3; 1/6 and 1/12 of IC50, to determine the combination index (CI) of cisplatin, CEE and AEE under MTT assay. The result showed that the combination of 2.5 µM, 5 µg/ml, 1 µg/ml concentrations of  cisplatin, CEE and AEE respectively result in synergistic effect with CI values less than 1. The treatment exhibited the cell accumulation in S phase (27.7%) against T47D breast cancer cells confirmed through cell cycle examination by flow cytometry. These results provided the evidence that the CEE and the AEE can be developed as co-chemotherapeutic agents combined with cisplatin to improve the effectiveness of breast cancer treatment.Keywords : Curcuma xanthorriza Roxb., Ficus septica Burm.f., cisplatin, cell cycle</dc:description>
	<dc:publisher xml:lang="en-US">Indonesian Society for Cancer Chemoprevention</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2017-10-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/186</dc:identifier>
	<dc:identifier>10.14499/indonesianjcanchemoprev8iss3pp120-125</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 8, No 3 (2017); 120-125</dc:source>
	<dc:source>2355-8989</dc:source>
	<dc:source>2088-0197</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/186/149</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 Indonesian Journal of Cancer Chemoprevention</dc:rights>
</oai_dc:dc>