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Pentagamaboronon-0 Fructose Inhibited Migration and Overexpression of Matrix Metalloproteinases 9 on MCF-7/HER2 Breast Cancer Cells

Indonesian Journal of Cancer Chemoprevention · Vol. 9 No. 3 (2018) · pp. 134–142

DOI
10.14499/indonesianjcanchemoprev9iss3pp134-142
ISSN
2355-8989, 2088-0197
Published
2018-10-30
Publisher
Indonesian Society for Cancer Chemoprevention
Language
eng

Abstract

The incidence of Breast Cancer Metastasis (MBC) can be categorized in stage IV as well as being the leading cause of death in cases of breast cancer. MBC prognosis is known to be weak, frequent recurrent, and MBC patients have only a survival rate of about 5 years. One of the proteins that causes breast cancer metastasis is Human Epidermal Growth Factor 2 (HER2). Pentagamaboron-0 (PGB-0), a newly curcumin analogue performed cytotoxic effect on HER2-positive breast cancer cells but it is practically water-insoluble. The aims of this study are to determine anti-metastatic activity of a more soluble form of PGB-0 namely PGB-0 fructose complex (PGB-0-F) toward HER2 positive cancer (MCF-7/HER2) cells. PGB-0-F was obtained from Cancer Chemoprevention Research Centre Faculty of Pharmacy Universitas Gadjah Mada. Based on scratch wound healing assay result, PGB-0-F inhibited cell migration especially in combination with doxorubicin at the concentration 15 μM. Under gelatin zymography assay, PGB-0-F in combination with doxorubicin decreased Matrix Metalloproteinases 9 (MMP-9) expression compare to the doxorubicin. Hence, PGB-0-F has a potency to be developed as anti-metastatic agent on HER2 overexpression breast cancer.Keywords: HER2, MCF-7/HER2, PGB-0-F, Metastasis

Collaboration network of the authors

40 authors · 136 co-authorship links · showing the 40 most connected

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  • University of Brawijaya
  • IPB University
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Ratna Asmah SusidartiAffiliation unknown25
Adam HermawanAffiliation unknown25
Muthi’ IkawatiAffiliation unknown14
Sri HandayaniUniversity of Brawijaya9
Dyaningtyas Dewi Pamungkas PutriAffiliation unknown8
Dhania NovitasariAffiliation unknown6
Annisa NovarinaAffiliation unknown6
Sari HaryantiAffiliation unknown5
Retno MurwantiAffiliation unknown5
Lailatul QodriaAffiliation unknown5
Faaza Aulia RahmanAffiliation unknown4
Desty Restia RahmawatiAffiliation unknown4
Ummi Maryam ZulfinAffiliation unknown4
Zalinar UdinAffiliation unknown4
Hilyatul FadliyahAffiliation unknown4
Nindya Budiana PutriAffiliation unknown4
Anindyajati AnindyajatiAffiliation unknown3
Larasati LarasatiIPB University3
Erlina RivantiAffiliation unknown3
Gergorius Gena MaranAffiliation unknown3
Beni LestariAffiliation unknown3
Laeli MuntafiahAffiliation unknown3
Bani Adlina ShabrinaAffiliation unknown3
Rumiyati RumiyatiAffiliation unknown3
Masashi KawaichiAffiliation unknown2
Sendy JunediAffiliation unknown2
Nunuk Aries NurulitaAffiliation unknown2
Suwijiyo PramonoAffiliation unknown2
Aulia Nur SeptianiAffiliation unknown2
Laili Nailul MunaAffiliation unknown2
Sofa FaridaAffiliation unknown2
Asri Mega PutriAffiliation unknown2
Indri KusharyantiAffiliation unknown2
Yonika Arum LarasatiAffiliation unknown2
Argandita MeiftasariAffiliation unknown2

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ijcc.chemoprev.org/index.php/ijcc/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Pentagamaboronon-0 Fructose Inhibited Migration and Overexpression of Matrix Metalloproteinases 9 on MCF-7/HER2 Breast Cancer Cells</dc:title>
	<dc:creator>Hairunisa, Indah</dc:creator>
	<dc:creator>Utomo, Rohmad Yudi</dc:creator>
	<dc:creator>Ertanto, Yogi</dc:creator>
	<dc:creator>Jenie, Riris Istighfari</dc:creator>
	<dc:creator>Meiyanto, Edy</dc:creator>
	<dc:description xml:lang="en-US">The incidence of Breast Cancer Metastasis (MBC) can be categorized in stage IV as well as being the leading cause of death in cases of breast cancer. MBC prognosis is known to be weak, frequent recurrent, and MBC patients have only a survival rate of about 5 years. One of the proteins that causes breast cancer metastasis is Human Epidermal Growth Factor 2 (HER2). Pentagamaboron-0 (PGB-0), a newly curcumin analogue performed cytotoxic effect on HER2-positive breast cancer cells but it is practically water-insoluble. The aims of this study are to determine anti-metastatic activity of a more soluble form of PGB-0 namely PGB-0 fructose complex (PGB-0-F) toward HER2 positive cancer (MCF-7/HER2) cells. PGB-0-F was obtained from Cancer Chemoprevention Research Centre Faculty of Pharmacy Universitas Gadjah Mada. Based on scratch wound healing assay result, PGB-0-F inhibited cell migration especially in combination with doxorubicin at the concentration 15 μM. Under gelatin zymography assay, PGB-0-F in combination with doxorubicin decreased Matrix Metalloproteinases 9 (MMP-9) expression compare to the doxorubicin. Hence, PGB-0-F has a potency to be developed as anti-metastatic agent on HER2 overexpression breast cancer.Keywords : HER2, MCF-7/HER2, PGB-0-F, Metastasis</dc:description>
	<dc:publisher xml:lang="en-US">Indonesian Society for Cancer Chemoprevention</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2018-10-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/242</dc:identifier>
	<dc:identifier>10.14499/indonesianjcanchemoprev9iss3pp134-142</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 9, No 3 (2018); 134-142</dc:source>
	<dc:source>2355-8989</dc:source>
	<dc:source>2088-0197</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/242/170</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 Indah Hairunisa</dc:rights>
</oai_dc:dc>