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Antiproliferative Activity of Ethanolic Extract of Ciplukan Herbs (Physalis angulata L.) on 7,12-Dimethylbenz[A]Nthracene-Induced Rat Mammary Carcinogenesis

Indonesian Journal of Cancer Chemoprevention · Vol. 2 No. 2 (2011) · pp. 228–233

DOI
10.14499/indonesianjcanchemoprev2iss2pp228-233
ISSN
2355-8989, 2088-0197
Published
2011-06-28
Publisher
Indonesian Society for Cancer Chemoprevention
Language
eng

Abstract

Physalis angulata L. is an annual herb widely used as popular medicine for the treatment of cancer. Physalis angulata L. ethanolic extract (PEE) has been demonstrated to have strong cytotoxic activity against breast cancer, inhibited cancer cell’s proliferation and induced cell cycle arrest. The aim of our study is to investigate the effect of PEE as a cancer chemopreventive agent on 7,12-dimethylbenz[a]nthracene (DMBA)-induced rats mammary. The antiproliferative activity was characterized by monitoring the histopatology representation and expression of cell proliferation on DMBA-induced mammary rats that were treated with PEE against control groups. The histopatology representation were analyzed by Haematoksilin Eosin (HE) staining method, while proliferative activity was detected by AgNOR method. The HE staining results showed significant differences in cells morphology of treatment groups compared to the control groups. Thus results suggest that PEE was able to repair morphology of cells undergoing carcinogenesis. AgNOR method showed decreasing occurrence of black dots between treatment and control groups. Thus, we conclude that PEE has an antiproliferative activity on DMBA-induced rat mammary. Therefore, the ethanolic extract of Physalis angulata herbs is a potential chemopreventive agent on cancer. Further study on its molecular mechanism needs to be explored.Keywords: Physalis angulata, breast cancer, 7,12-dimethylbenz[a]nthracene, carcinogenesis, antiproliferative

Collaboration network of the authors

40 authors · 138 co-authorship links · showing the 40 most connected

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  • University of Brawijaya
  • IPB University
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
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Co-authorOrganisationJoint articles
Ratna Asmah SusidartiAffiliation unknown18
Adam HermawanAffiliation unknown18
Riris Istighfari JenieAffiliation unknown14
Muthi’ IkawatiAffiliation unknown11
Rohmad Yudi UtomoAffiliation unknown8
Dyaningtyas Dewi Pamungkas PutriAffiliation unknown7
Sari HaryantiAffiliation unknown5
Dhania NovitasariAffiliation unknown4
Retno MurwantiAffiliation unknown4
Faaza Aulia RahmanAffiliation unknown4
Desty Restia RahmawatiAffiliation unknown4
Sri HandayaniUniversity of Brawijaya3
Ummi Maryam ZulfinAffiliation unknown3
Anindyajati AnindyajatiAffiliation unknown3
Larasati LarasatiIPB University3
Erlina RivantiAffiliation unknown3
Masashi KawaichiAffiliation unknown2
Sendy JunediAffiliation unknown2
Nunuk Aries NurulitaAffiliation unknown2
Suwijiyo PramonoAffiliation unknown2
Zalinar UdinAffiliation unknown2
Yogi ErtantoAffiliation unknown2
Lailatul QodriaAffiliation unknown2
Gergorius Gena MaranAffiliation unknown2
Aulia Nur SeptianiAffiliation unknown2
Beni LestariAffiliation unknown2
Asri Mega PutriAffiliation unknown2
Hilyatul FadliyahAffiliation unknown2
Indri KusharyantiAffiliation unknown2
Yonika Arum LarasatiAffiliation unknown2
Raditya Prima IstiajiAffiliation unknown2
Ni Putu Linda LaksmianiAffiliation unknown2
Nanda Resa PratamaAffiliation unknown2
Nindya Budiana PutriAffiliation unknown2
Herwandhani PutriAffiliation unknown2

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ijcc.chemoprev.org/index.php/ijcc/oai, first harvested 8 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Antiproliferative Activity of Ethanolic Extract of Ciplukan Herbs (Physalis angulata L.) on 7,12-Dimethylbenz[A]Nthracene-Induced Rat Mammary Carcinogenesis</dc:title>
	<dc:creator>Monikawati, Ameilinda</dc:creator>
	<dc:creator>Farida, Sofa</dc:creator>
	<dc:creator>Putri, Laras Widawaty</dc:creator>
	<dc:creator>Ikhtiarsyah, Yurista Gilang</dc:creator>
	<dc:creator>Meiyanto, Edy</dc:creator>
	<dc:description xml:lang="en-US">Physalis angulata L. is an annual herb widely used as popular medicine for the treatment of cancer. Physalis angulata L. ethanolic extract (PEE) has been demonstrated to have strong cytotoxic activity against breast cancer, inhibited cancer cell’s proliferation and induced cell cycle arrest. The aim of our study is to investigate the effect of PEE as a cancer chemopreventive agent on 7,12-dimethylbenz[a]nthracene (DMBA)-induced rats mammary. The antiproliferative activity was characterized by monitoring the histopatology representation and expression of cell proliferation on DMBA-induced mammary rats that were treated with PEE against control groups. The histopatology representation were analyzed by Haematoksilin Eosin (HE) staining method, while proliferative activity was detected by AgNOR method. The HE staining results showed significant differences in cells morphology of treatment groups compared to the control groups. Thus results suggest that PEE was able to repair morphology of cells undergoing carcinogenesis. AgNOR method showed decreasing occurrence of black dots between treatment and control groups. Thus, we conclude that PEE has an antiproliferative activity on DMBA-induced rat mammary. Therefore, the ethanolic extract of Physalis angulata herbs is a potential chemopreventive agent on cancer. Further study on its molecular mechanism needs to be explored.Keywords: Physalis angulata, breast cancer, 7,12-dimethylbenz[a]nthracene, carcinogenesis, antiproliferative </dc:description>
	<dc:publisher xml:lang="en-US">Indonesian Society for Cancer Chemoprevention</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2011-06-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ijcc.chemoprev.org/index.php/ijcc/article/view/36</dc:identifier>
	<dc:identifier>10.14499/indonesianjcanchemoprev2iss2pp228-233</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Cancer Chemoprevention; Vol 2, No 2 (2011); 228-233</dc:source>
	<dc:source>2355-8989</dc:source>
	<dc:source>2088-0197</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ijcc.chemoprev.org/index.php/ijcc/article/view/36/37</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2017 Indonesian Journal of Cancer Chemoprevention</dc:rights>
</oai_dc:dc>