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Biochemical and Histopathological Effect of Combination Extract Ethanolic Turmeric (Curcuma longa) and Kalmegh (Andrographis paniculata) in Iron Overload Rat Model

Journal of Biomedicine and Translational Research · Vol. 12 No. 1 (2026) · pp. 7–13

DOI
10.14710/jbtr.v12i1.28945
ISSN
2503-2178
Published
2026-04-30
Publisher
Faculty of Medicine, Universitas Diponegoro
Language
eng
License
creativecommons.org/licenses/by-sa/4.0

Abstract

Background: Thalassemia-β patients have erythrocyte damage that requires blood transfusion treatment. Blood transfusion treatment that is undergone has an impact on the condition of iron overload in the body. The condition of iron overload will result in oxidative stress and organ damage that requires additional therapyObjective: aimed to compare the effectiveness of turmeric and kalmegh extract doses against biochemical parameters and histopathological features of iron-induced liver Rattus Norvegicus.Methods: This study used a True-experiment research design with a post-test-only control group. A total of 30 rats were used and divided into six treatment groups, normal, deferiprone drugs, turmeric, and kalmegh extracts 100mg/KgBW, 200mg/KgBW, and 400mg/KgBW. Malondialdehyde, catalase, superoxide dismutase, and ferritin are used as biochemical parameters and hepatic histopathology is documented.Results: The results showed that there were significant improvements and differences in iron-induced rats.Conclusion: The study also showed that turmeric and kalmegh extracts had similar effects to deferiprone.

Keywords

Collaboration network of the authors

40 authors · 122 co-authorship links · showing the 40 most connected

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  • Universitas Halu Oleo
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
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Co-authorOrganisationJoint articles
Sefrilita Risqi Adikaning Rani RaniAffiliation unknown4
Joko MulyantoAffiliation unknown2
La Ode Ali BasriAffiliation unknown1
Nasruddin SuyutiAffiliation unknown1
Any AryaniAffiliation unknown1
Rita ShintawatiAffiliation unknown1
Muh Said LAffiliation unknown1
Prasepvianto Estu BrotoAffiliation unknown1
Nidya Lena Fitriah LaksanaAffiliation unknown1
Sefrilita SefrilitaAffiliation unknown1
Nuraeni NuraeniAffiliation unknown1
Sefrilita Risqi Adikaning RaniAffiliation unknown1
M. Said LAffiliation unknown1
Ananda Anindia PutriAffiliation unknown1
Sahara SaharaUniversitas Halu Oleo1
Indrawati.A AAffiliation unknown1
Prasepvianto Estu BrotoAffiliation unknown1
Juliana JulianaAffiliation unknown1
Rahmaniah RahmaniahAffiliation unknown1
Putriani PutrianiAffiliation unknown1
Asriani AsrianiAffiliation unknown1
Lora SantikaAffiliation unknown1
Soraya GigentikaAffiliation unknown1
Muhammad Hafidz Ibnu KhaldunAffiliation unknown1
Putu Satya Pratama AtmajaAffiliation unknown1
Wiwid Andriyani LestariningsihAffiliation unknown1
Mahardika Rizqi HimawanAffiliation unknown1
Ibadur RahmanAffiliation unknown1
Mahbub MurtiyosoAffiliation unknown1
Cahya HimawanAffiliation unknown1
Rendy Vidya WibisonoAffiliation unknown1
Teguh Haryo SasongkoAffiliation unknown1
Dwi Utami AnjarwatiAffiliation unknown1
Gembong Satria MahardhikaAffiliation unknown1
Metta Ayu SusantiAffiliation unknown1
Indah PuspariniAffiliation unknown1
Dyah Woro Dwi LestariAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ejournal2.undip.ac.id/index.php/jbtr/oai, first harvested 9 Nov 2026, last seen 9 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Biochemical and Histopathological Effect of Combination Extract Ethanolic Turmeric (Curcuma longa) and Kalmegh (Andrographis paniculata) in Iron Overload Rat Model</dc:title>
	<dc:creator>Prastiyo, M. Dodik</dc:creator>
	<dc:creator>Rujito, Lantip</dc:creator>
	<dc:creator>Hernawati, Hernawati</dc:creator>
	<dc:subject xml:lang="en-US">Iron Overload;  Kalmegh; Oxidative stress; Thalassemia; Turmeric</dc:subject>
	<dc:description xml:lang="en-US">Background: Thalassemia-β patients have erythrocyte damage that requires blood transfusion treatment. Blood transfusion treatment that is undergone has an impact on the condition of iron overload in the body. The condition of iron overload will result in oxidative stress and organ damage that requires additional therapyObjective: aimed to compare the effectiveness of turmeric and kalmegh extract doses against biochemical parameters and histopathological features of iron-induced liver Rattus Norvegicus.Methods: This study used a True-experiment research design with a post-test-only control group. A total of 30 rats were used and divided into six treatment groups, normal, deferiprone drugs, turmeric, and kalmegh extracts 100mg/KgBW, 200mg/KgBW, and 400mg/KgBW. Malondialdehyde, catalase, superoxide dismutase, and ferritin are used as biochemical parameters and hepatic histopathology is documented.Results: The results showed that there were significant improvements and differences in iron-induced rats.Conclusion: The study also showed that turmeric and kalmegh extracts had similar effects to deferiprone.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Medicine, Universitas Diponegoro</dc:publisher>
	<dc:date>2026-04-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
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	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ejournal2.undip.ac.id/index.php/jbtr/article/view/28945</dc:identifier>
	<dc:identifier>10.14710/jbtr.v12i1.28945</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Biomedicine and Translational Research; Vol 12, No 1 (2026): April 2026; 7-13</dc:source>
	<dc:source>2503-2178</dc:source>
	<dc:source>10.14710/jbtr.v12i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ejournal2.undip.ac.id/index.php/jbtr/article/view/28945/14189</dc:relation>
	<dc:relation>https://ejournal2.undip.ac.id/index.php/jbtr/article/downloadSuppFile/28945/7110</dc:relation>
	<dc:relation>https://ejournal2.undip.ac.id/index.php/jbtr/article/downloadSuppFile/28945/7844</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2026 Journal of Biomedicine and Translational Research</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>