Melola Discovery

← Melola Discovery

Open access Journal SINTA 1

Stress-driven metabolic adaptation of Passiflora foetida L. root across coal mine reclamation ages: Linking soil chemistry, metabolomics and bioactivity

Journal of Degraded and Mining Lands Management · Vol. 13 No. 4 (2026) · pp. 11185–11199

DOI
10.15243/jdmlm.2026.134.11185
ISSN
2502-2458, 2339-076X
Published
2026-10-01
Publisher
Brawijaya University
Language
eng
License
creativecommons.org/licenses/by-nc/4.0

Abstract

Coal reclamation sites, characterized by low pH and high heavy metal concentrations, serve as invaluable stress laboratories. Plants growing in these environments are forced to upregulate secondary metabolic pathways as a defense mechanism against oxidative stress. This stress condition makes the flora of coal reclamation sites a more concentrated source of bioactive compounds than plants in normal soil. This study profiled the bioactive compounds and analyzed the biological activity of Passiflora foetida L. root extracts based on the age of the reclamation site. The ethanol extracts from P. foetida plants were fractionated to identify the bioactive compounds. The bioactive compound profile was determined using LC-QTOF-MS-based untargeted detection methods, while the biological activity analysis included the evaluation of antioxidant and antimicrobial properties in each obtained fraction. Chemical profiling revealed highly significant differences in compound composition among the various sample types. Across all bioassays, the ethyl acetate fraction from the reclamation sample was consistently the most active, confirming that semi-polar alkaloids, flavonoids, and terpenoids are the dominant pharmacophore classes in the root extracts of P. foetida. Analysis of the abundance of compounds produced in response to stress at the reclamation site indicates pharmacological potential, supporting the value of plant material from both locations as a source of bioactive natural products. This demonstrates the significant potential of the downstream processing of former mining sites into promising sources of natural medicines.

Keywords

Collaboration network of the authors

40 authors · 104 co-authorship links · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • Sekolah Tinggi Agama Buddha Negeri Raden Wijaya Wonogiri
  • University of Brawijaya
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Yoga Dwi JatmikoAffiliation unknown2
Sutrisno SutrisnoSekolah Tinggi Agama Buddha Negeri Raden Wijaya Wonogiri2
Izaz Aqeiluz ZaharaAffiliation unknown2
Amin Setyo LeksonoAffiliation unknown1
Wildania Putri AgustinaAffiliation unknown1
Marsa SalsabilaAffiliation unknown1
Nabila Fitri RosyidaAffiliation unknown1
Riska Putri QurotaayuninaAffiliation unknown1
Nia KurniawanAffiliation unknown1
Anisa ZairinaAffiliation unknown1
Hakan BozdoğanAffiliation unknown1
Suharjono SuharjonoAffiliation unknown1
Evi OctavianyAffiliation unknown1
Elsa Mega SuryaniAffiliation unknown1
Hikmah MaulidiyahAffiliation unknown1
Salam A. IbrahimAffiliation unknown1
Eka NovitasariAffiliation unknown1
Momodou Salieu SoweAffiliation unknown1
Arda Rista LestariAffiliation unknown1
Masruri MasruriAffiliation unknown1
Yuniar Ponco PranantoAffiliation unknown1
Ahmad Sholeh RomdlonAffiliation unknown1
NurjanahAffiliation unknown1
Binawati GintingAffiliation unknown1
Ilham MaulanaAffiliation unknown1
Tasya UlfikaAffiliation unknown1
Dian SiswantoUniversity of Brawijaya1
Idham Halil ZakariaAffiliation unknown1
Arie SrihardyastutieAffiliation unknown1
Aulanni’am Aulanni’amAffiliation unknown1
Anna RoosdianaAffiliation unknown1
Eva Nur Laili OctavianaAffiliation unknown1
Syukria I ZamAffiliation unknown1
Syamsuardi SyamsuardiAffiliation unknown1
Anthoni AgustienAffiliation unknown1
Syukria Ikhsan ZamAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://jdmlm.ub.ac.id/index.php/jdmlm/oai, first harvested 9 Nov 2026, last seen 9 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Stress-driven metabolic adaptation of Passiflora foetida L. root across coal mine reclamation ages: Linking soil chemistry, metabolomics and bioactivity  </dc:title>
	<dc:creator>Meray, Nishia Waya</dc:creator>
	<dc:creator>Safitri, Anna</dc:creator>
	<dc:creator>Ulfa, Siti Mariyah</dc:creator>
	<dc:creator>Mustafa, Irfan</dc:creator>
	<dc:subject xml:lang="en-US">biological activities</dc:subject>
	<dc:subject xml:lang="en-US">Passifora foetida L</dc:subject>
	<dc:subject xml:lang="en-US">post-mining</dc:subject>
	<dc:subject xml:lang="en-US">reclamation</dc:subject>
	<dc:subject xml:lang="en-US">stress metabolic</dc:subject>
	<dc:description xml:lang="en-US">Coal reclamation sites, characterized by low pH and high heavy metal concentrations, serve as invaluable stress laboratories. Plants growing in these environments are forced to upregulate secondary metabolic pathways as a defense mechanism against oxidative stress. This stress condition makes the flora of coal reclamation sites a more concentrated source of bioactive compounds than plants in normal soil. This study profiled the bioactive compounds and analyzed the biological activity of Passiflora foetida L. root extracts based on the age of the reclamation site. The ethanol extracts from P. foetida plants were fractionated to identify the bioactive compounds. The bioactive compound profile was determined using LC-QTOF-MS-based untargeted detection methods, while the biological activity analysis included the evaluation of antioxidant and antimicrobial properties in each obtained fraction. Chemical profiling revealed highly significant differences in compound composition among the various sample types. Across all bioassays, the ethyl acetate fraction from the reclamation sample was consistently the most active, confirming that semi-polar alkaloids, flavonoids, and terpenoids are the dominant pharmacophore classes in the root extracts of P. foetida. Analysis of the abundance of compounds produced in response to stress at the reclamation site indicates pharmacological potential, supporting the value of plant material from both locations as a source of bioactive natural products. This demonstrates the significant potential of the downstream processing of former mining sites into promising sources of natural medicines.</dc:description>
	<dc:publisher xml:lang="en-US">Brawijaya University</dc:publisher>
	<dc:date>2026-10-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jdmlm.ub.ac.id/index.php/jdmlm/article/view/17943</dc:identifier>
	<dc:identifier>10.15243/jdmlm.2026.134.11185</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Degraded and Mining Lands Management; Vol. 13 No. 4 (2026); 11185–11199</dc:source>
	<dc:source>2502-2458</dc:source>
	<dc:source>2339-076X</dc:source>
	<dc:source>10.15243/jdmlm.2026.134</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jdmlm.ub.ac.id/index.php/jdmlm/article/view/17943/2157</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2026 Journal of Degraded and Mining Lands Management</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-nc/4.0</dc:rights>
</oai_dc:dc>