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Modelling Multiple Dosing with Drug Holiday in Antiretroviral Treatment on HIV-1 Infection

Journal of Mathematical and Fundamental Sciences · Vol. 49 No. 1 (2017) · pp. 1–17

DOI
10.5614/j.math.fund.sci.2017.49.1.1
ISSN
2338-5510, 2337-5760
Published
2017-04-06
Publisher
Directorate for Research and Innovation (DRI) ITB
Language
eng

Abstract

A within-host mathematical model to describe the dynamics of target cells and viral load in early HIV-1 infection was developed, which incorporates a combination of RTI and PI treatments by using a pharmacokinetics model. The local stability of uninfected steady state for the model was determined using an alternative threshold. The pharmacokinetics model was employed to estimate drug efficacy in multiple drug dosing. The effect of periodic drug efficacy of pharmacokinetic type on outcome of HIV-1 infection was explored under various treatment interruptions. The effectiveness of treatment interruption was determined according to the time period of the drug holidays. The results showed that long drug holidays lead to therapy failure. Under interruption of treatments combining RTI and PI therapy, effectiveness of the treatment requires a short duration of the drug holiday.

Keywords

Collaboration network of the authors

40 authors · 123 co-authorship links · 2 across different organisations · showing the 40 most connected

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  • Bandung Institute of Technology
  • Tadulako University
  • National Research and Innovation Agency
  • Institut Teknologi Kalimantan
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Muhammad FakhruddinAffiliation unknown5
Edy SoewonoAffiliation unknown3
Mochamad ApriBandung Institute of Technology3
Hadi SusantoNational Research and Innovation Agency2
Juni Wijayanti PuspitaTadulako University2
Hilda FahlenaAffiliation unknown2
Mia Siti KhumaerohAffiliation unknown1
Sunarsih SunarsihAffiliation unknown1
R. Heru TjahjanaAffiliation unknown1
Karunia Putra WijayaAffiliation unknown1
Ilham Saiful FauziAffiliation unknown1
Fatkhur RohimAffiliation unknown1
Yenie SyukriyahAffiliation unknown1
Rudy KusdiantaraAffiliation unknown1
Kamal KhairudinAffiliation unknown1
Vania Mene RisrianiAffiliation unknown1
Tjandra AnggraeniAffiliation unknown1
Anita TriskaAffiliation unknown1
Mona ZevikaAffiliation unknown1
Glenn Lahodny Jr.Affiliation unknown1
. FaridaAffiliation unknown1
Widya OktavianaAffiliation unknown1
. SudirmanAffiliation unknown1
DILA PUSPITAAffiliation unknown1
Agus HasanAffiliation unknown1
Yuki NasutionAffiliation unknown1
Endah PutriAffiliation unknown1
Venansius TjahjonoAffiliation unknown1
Kamal SukandarAffiliation unknown1
WidyastutiAffiliation unknown1
NadiaAffiliation unknown1
Chai Jian TayAffiliation unknown1
Afdol ZikriAffiliation unknown1
Sila RizqinaAffiliation unknown1
Kamal Khairudin SukandarAffiliation unknown1
Retno Wahyu DewantiInstitut Teknologi Kalimantan1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journals.itb.ac.id/index.php/jmfs/oai, first harvested 9 Nov 2026, last seen 9 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Modelling Multiple Dosing with Drug Holiday in Antiretroviral Treatment on HIV-1 Infection</dc:title>
	<dc:creator>Sutimin, Sutimin</dc:creator>
	<dc:creator>Nuraini, Nuning</dc:creator>
	<dc:creator>Chirove, Faraimunashe</dc:creator>
	<dc:creator>Suromo, Lisyani Budipradigda</dc:creator>
	<dc:subject xml:lang="en-US">CD4 T cells</dc:subject>
	<dc:subject xml:lang="en-US">drug holiday</dc:subject>
	<dc:subject xml:lang="en-US">HIV-1</dc:subject>
	<dc:subject xml:lang="en-US">Langerhans</dc:subject>
	<dc:subject xml:lang="en-US">pharmacokinetics</dc:subject>
	<dc:description xml:lang="en-US">A within-host mathematical model to describe the dynamics of target cells and viral load in early HIV-1 infection was developed, which incorporates a combination of RTI and PI treatments by using a pharmacokinetics model. The local stability of uninfected steady state for the model was determined using an alternative threshold. The pharmacokinetics model was employed to estimate drug efficacy in multiple drug dosing. The effect of periodic drug efficacy of pharmacokinetic type on outcome of HIV-1 infection was explored under various treatment interruptions. The effectiveness of treatment interruption was determined according to the time period of the drug holidays. The results showed that long drug holidays lead to therapy failure. Under interruption of treatments combining RTI and PI therapy, effectiveness of the treatment requires a short duration of the drug holiday. </dc:description>
	<dc:publisher xml:lang="en-US">Directorate for Research and Innovation (DRI) ITB</dc:publisher>
	<dc:date>2017-04-06</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journals.itb.ac.id/index.php/jmfs/article/view/2132</dc:identifier>
	<dc:identifier>10.5614/j.math.fund.sci.2017.49.1.1</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Mathematical and Fundamental Sciences; Vol. 49 No. 1 (2017); 1-17</dc:source>
	<dc:source>2338-5510</dc:source>
	<dc:source>2337-5760</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journals.itb.ac.id/index.php/jmfs/article/view/2132/1846</dc:relation>
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