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Havanensin-type Limonoids from the Stem Bark of Chisocheton pentandrus (Meliaceae)

Journal of Mathematical and Fundamental Sciences · Vol. 54 No. 3 (2023) · pp. 302–310

DOI
10.5614/j.math.fund.sci.2023.54.3.2
ISSN
2338-5510, 2337-5760
Published
2023-05-15
Publisher
Directorate for Research and Innovation (DRI) ITB
Language
eng

Abstract

A new limonoid, belonging to the havanensin-type, called pentandricine E (1), alongside four other known types, i.e., trichilenone acetate (2), toonaciliatones C (3), 11α-acetoxyazadirone (4) and ceramicine I (5), were found in Chisocheton pentandrus stem bark. The structures of the isolated 1-5 were identified by NMR spectroscopy and HRTOFMS. Pentandricine E (1) displayed the highest cytotoxicity toward the MCF-7 breast cancer line with an IC50 value of 63.27 ± 0.21 mM.

Keywords

Collaboration network of the authors

40 authors · 289 co-authorship links · showing the 40 most connected

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  • University of Malaya
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Nurlelasari NurlelasariAffiliation unknown52
Kindi FarabiAffiliation unknown50
Al Arofatus NainiAffiliation unknown32
Sofa FajriahAffiliation unknown31
Ace Tatang HidayatAffiliation unknown25
Darwati DarwatiAffiliation unknown22
Mohamad Nurul AzmiAffiliation unknown16
Erina HilmayantiAffiliation unknown12
Dewa Gede KatjaAffiliation unknown11
Wahyu SafriansyahAffiliation unknown9
Hadi KuncoroAffiliation unknown8
Risyandi AnwarAffiliation unknown8
Tati HerlinaAffiliation unknown7
Khalijah AwangUniversity of Malaya7
Harizon HarizonAffiliation unknown7
Muhammad HanafiAffiliation unknown7
Mohamad Azlan NafiahAffiliation unknown7
Fajar Fauzi AbdullahAffiliation unknown6
Agus SafariAffiliation unknown6
Ricson Pemimpin HutagaolAffiliation unknown6
Euis JulaehaAffiliation unknown5
Ronny LesmanaAffiliation unknown5
Sandra Amalia RiyadiAffiliation unknown5
Ferry Ferdiansyah SofianAffiliation unknown5
Laode RijaiAffiliation unknown4
Susianti SusiantiAffiliation unknown3
Raihan Fathurrahman HasbillaAffiliation unknown3
Sari PurbayaAffiliation unknown3
Aprilia Permata SariAffiliation unknown3
Rurini RetnowatiAffiliation unknown3
Mohd Azlan NafiahAffiliation unknown2

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journals.itb.ac.id/index.php/jmfs/oai, first harvested 9 Nov 2026, last seen 9 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Havanensin-type Limonoids from the Stem Bark of Chisocheton pentandrus (Meliaceae)</dc:title>
	<dc:creator>Runadi, Dudi</dc:creator>
	<dc:creator>Purnama, Purnama</dc:creator>
	<dc:creator>Salam, Supriatno </dc:creator>
	<dc:creator>Nurlelasari, Nulelasari</dc:creator>
	<dc:creator>Harneti, Desi</dc:creator>
	<dc:creator>Mayanti, Tri </dc:creator>
	<dc:creator>Maharani, Rani </dc:creator>
	<dc:creator>Supratman, Unang</dc:creator>
	<dc:creator>Shiono, Yoshihito</dc:creator>
	<dc:subject xml:lang="en-US">Chisocheton pentandrus</dc:subject>
	<dc:subject xml:lang="en-US">havanensin-type</dc:subject>
	<dc:subject xml:lang="en-US">MCF-7</dc:subject>
	<dc:subject xml:lang="en-US">pentandricine E</dc:subject>
	<dc:subject xml:lang="en-US">Chemistry</dc:subject>
	<dc:description xml:lang="en-US">A new limonoid, belonging to the havanensin-type, called pentandricine E (1), alongside four other known types, i.e., trichilenone acetate (2), toonaciliatones C (3), 11α-acetoxyazadirone (4) and ceramicine I (5), were found in Chisocheton pentandrus stem bark. The structures of the isolated 1-5 were identified by NMR spectroscopy and HRTOFMS. Pentandricine E (1) displayed the highest cytotoxicity toward the MCF-7 breast cancer line with an IC50 value of 63.27 ± 0.21 mM.</dc:description>
	<dc:publisher xml:lang="en-US">Directorate for Research and Innovation (DRI) ITB</dc:publisher>
	<dc:date>2023-05-15</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journals.itb.ac.id/index.php/jmfs/article/view/19268</dc:identifier>
	<dc:identifier>10.5614/j.math.fund.sci.2023.54.3.2</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Mathematical and Fundamental Sciences; Vol. 54 No. 3 (2023); 302-310</dc:source>
	<dc:source>2338-5510</dc:source>
	<dc:source>2337-5760</dc:source>
	<dc:source>10.5614/j.math.fund.sci.2023.54.3</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journals.itb.ac.id/index.php/jmfs/article/view/19268/6204</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Journal of Mathematical and Fundamental Sciences</dc:rights>
</oai_dc:dc>