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Penta- and Tetra-cyclic Triterpenoids from Aglaia cucullata Stembark and Cytotoxicity against Cancer and Normal Cells

Journal of Mathematical and Fundamental Sciences · Vol. 57 No. 2 (2025) · pp. 86–95

DOI
10.5614/j.math.fund.sci.2025.57.2.1
ISSN
2338-5510, 2337-5760
Published
2025-11-29
Publisher
Directorate for Research and Innovation (DRI) ITB
Language
eng
License
creativecommons.org/licenses/by-nc-nd/4.0

Abstract

Three triterpenoid compounds, belonging to the penta- and tetracyclic groups, were successively isolated from the stembark of Aglaia cucullata and identified as b-amyron (1), dammaradienon (2), and cabralealactone (3). After extensive extraction, chromatographic separation and purification, compounds 1 to 3 were gained. Spectroscopic analysis in addition to HRMS, FTIR, 1D and 2D NMR analysis were utilized to determine the chemical structure. After that, compounds 1 to 3 were tested against breast cancer, melanoma as well as normal kidney cells (MCF-7, B16-F10, and CV-1, respectively). The resulted cytotoxicity test revealed that compound 1 had the best cytotoxicity against all cells compared with the other isolated compounds. This result suggests that the pentacyclic triterpenoid core in compound 1 increases cytotoxicity compared with a tetracyclic skeleton.

Keywords

Collaboration network of the authors

40 authors · 276 co-authorship links · showing the 40 most connected

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  • University of Malaya
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Nurlelasari NurlelasariAffiliation unknown44
Tri MayantiAffiliation unknown38
Rani MaharaniAffiliation unknown35
Al Arofatus NainiAffiliation unknown30
Yoshihito ShionoAffiliation unknown28
Ace Tatang HidayatAffiliation unknown23
Darwati DarwatiAffiliation unknown17
Mohamad Nurul AzmiAffiliation unknown12
Fajar Fauzi AbdullahAffiliation unknown10
Erina HilmayantiAffiliation unknown10
Euis JulaehaAffiliation unknown9
Dewa Gede KatjaAffiliation unknown9
Harizon HarizonAffiliation unknown9
Tati HerlinaAffiliation unknown8
Risyandi AnwarAffiliation unknown8
Khalijah AwangUniversity of Malaya7
Ricson Pemimpin HutagaolAffiliation unknown7
Ronny LesmanaAffiliation unknown6
Laode RijaiAffiliation unknown6
Tjandrawati MozefAffiliation unknown5
Gian PrimahanaAffiliation unknown5
Sandra Amalia RiyadiAffiliation unknown5
Dudi RunadiAffiliation unknown5
Purnama PurnamaAffiliation unknown5
Susianti SusiantiAffiliation unknown5
Raihan Fathurrahman HasbillaAffiliation unknown5
Muhammad HanafiAffiliation unknown5
Aprilia Permata SariAffiliation unknown5
Mohamad Azlan NafiahAffiliation unknown5
Agus SafariAffiliation unknown4
Akhmad DarmawanAffiliation unknown3
Sari PurbayaAffiliation unknown3
Marissa AngelinaAffiliation unknown2
Sofna Dewita Sari BanjarnahorAffiliation unknown2

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journals.itb.ac.id/index.php/jmfs/oai, first harvested 9 Nov 2026, last seen 9 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Penta- and Tetra-cyclic Triterpenoids from Aglaia cucullata Stembark and Cytotoxicity against Cancer and Normal Cells</dc:title>
	<dc:creator>Farabi, Kindi </dc:creator>
	<dc:creator>Safriansyah, Wahyu </dc:creator>
	<dc:creator>Harneti, Desi</dc:creator>
	<dc:creator>Kuncoro, Hadi</dc:creator>
	<dc:creator>Fajriah, Sofa</dc:creator>
	<dc:creator>Supratman, Unang</dc:creator>
	<dc:subject xml:lang="en-US">Aglaia</dc:subject>
	<dc:subject xml:lang="en-US">Aglaia cucullata</dc:subject>
	<dc:subject xml:lang="en-US">cytotoxic activity</dc:subject>
	<dc:subject xml:lang="en-US">Meliaceae</dc:subject>
	<dc:subject xml:lang="en-US">penta- and tetracyclic triterpenoids</dc:subject>
	<dc:subject xml:lang="en-US">Natural Products Chemistry</dc:subject>
	<dc:description xml:lang="en-US">Three triterpenoid compounds, belonging to the penta- and tetracyclic groups, were successively isolated from the stembark of Aglaia cucullata and identified as b-amyron (1), dammaradienon (2), and cabralealactone (3). After extensive extraction, chromatographic separation and purification, compounds 1 to 3 were gained. Spectroscopic analysis in addition to HRMS, FTIR, 1D and 2D NMR analysis were utilized to determine the chemical structure. After that, compounds 1 to 3 were tested against breast cancer, melanoma as well as normal kidney cells (MCF-7, B16-F10, and CV-1, respectively). The resulted cytotoxicity test revealed that compound 1 had the best cytotoxicity against all cells compared with the other isolated compounds. This result suggests that the pentacyclic triterpenoid core in compound 1 increases cytotoxicity compared with a tetracyclic skeleton.</dc:description>
	<dc:publisher xml:lang="en-US">Directorate for Research and Innovation (DRI) ITB</dc:publisher>
	<dc:date>2025-11-29</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journals.itb.ac.id/index.php/jmfs/article/view/25617</dc:identifier>
	<dc:identifier>10.5614/j.math.fund.sci.2025.57.2.1</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Mathematical and Fundamental Sciences; Vol. 57 No. 2 (2025); 86-95</dc:source>
	<dc:source>2338-5510</dc:source>
	<dc:source>2337-5760</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journals.itb.ac.id/index.php/jmfs/article/view/25617/7185</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 Journal of Mathematical and Fundamental Sciences</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-nc-nd/4.0</dc:rights>
</oai_dc:dc>