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Acute Toxicity Studies of Brucea javanica Merril Leaves Extract on Mice

Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences · Vol. 2 No. 2 (2012) · pp. 29–31

ISSN
2527-4376, 2087-5517
Published
2012-09-01
Publisher
Journal of Tropical Life Science
Language
eng
License
creativecommons.org/licenses/by-nc/4.0

Abstract

The objective of the study was to evaluate the oral acute toxicity of Brucea javanica Merril extract on both Male and Female DDY-Mice. Brucea javanica leaves have activity as a cytotoxic, anti-diarhhea, etc. Brucea javanica leaves extract was administered orally for first 24 hours at various dose levels (562.5mg/kg bw, 1125 mg/kg bw, 2250 mg/kg bw, and 4500 mg/kg bw) to determine the toxicity effects. The treatment groups were compared to the normal control. Vital organs (liver, heart, lymph, lungs, etc) and body weight were analyzed to study the toxicity. LD50 determined using Reed and Munich formula. Vital organs average weight showed no difference between control group and treatment groups from the lowest dose until the highest dose. In addition, the body weight data showed no difference between control group and treatment groups. LD50 for Brucea javanica extract using Reed and Munich formula was 1003.65 mg/kg bw. The result of the study showed that extract were categorized as lightly toxic.Keywords: Acute toxicity, Brucea javanica Merril, DDY-Mice, LD50

Collaboration network of the authors

40 authors · 224 co-authorship links · showing the 40 most connected

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  • National Research and Innovation Agency
  • Affiliation unknown
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  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Sofa FajriahAffiliation unknown3
Sofna Dewita Sari BanjarnahorAffiliation unknown3
Ferry IskandarAffiliation unknown2
Ernawati Arifin Giri-RachmanAffiliation unknown2
Hariyatun HariyatunAffiliation unknown2
Azzania FibrianiAffiliation unknown2
Yana RubiyanaAffiliation unknown2
Popi Hadi WisnuwardhaniAffiliation unknown2
Ratih Asmana NingrumAffiliation unknown2
Fitri Aulia PermatasariAffiliation unknown2
Dian Fitria AgustiyantiAffiliation unknown2
Andri WardianaAffiliation unknown2
Sri HartatiAffiliation unknown2
Lia MeilawatiAffiliation unknown2
Indah Dwiatmi DewijantiAffiliation unknown2
Vera PermatasariNational Research and Innovation Agency1
Dwi RetnowatiAffiliation unknown1
Muhammad AsrilAffiliation unknown1
Elisa Nurma RianaAffiliation unknown1
Tjandrawati MozefAffiliation unknown1
Indri YatiAffiliation unknown1
Irmanida BatubaraAffiliation unknown1
Muhammad Eka PrastyaAffiliation unknown1
Erma SuryantiAffiliation unknown1
Novita ArianiAffiliation unknown1
Apriza YuswanAffiliation unknown1
Desriani DesrianiAffiliation unknown1
Audrey Angelina Putri TaharuddinAffiliation unknown1
Nicholas YamahokiAffiliation unknown1
Rebecca StephanieAffiliation unknown1
Arum Sinda SantikaAffiliation unknown1
Nahdiya Laila MufidaAffiliation unknown1
Marya Salfia KhoerunisahAffiliation unknown1
Kasiyati KasiyatiAffiliation unknown1
Indah Dwiatmi DewiyantiAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://jtrolis.ub.ac.id/index.php/jtrolis/oai, first harvested 9 Nov 2026, last seen 9 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Acute Toxicity Studies of Brucea javanica Merril Leaves Extract on Mice</dc:title>
	<dc:creator xml:lang="en">Angelina, Marissa</dc:creator>
	<dc:creator xml:lang="en">Dewijanti, Indah D</dc:creator>
	<dc:creator xml:lang="en">S, Banjarnahor S D</dc:creator>
	<dc:creator xml:lang="en">megawati, Megawati</dc:creator>
	<dc:creator xml:lang="en">Yuliani, Tri</dc:creator>
	<dc:description xml:lang="en">The objective of the study was to evaluate the oral acute toxicity of Brucea javanica Merril extract on both Male and Female DDY-Mice. Brucea javanica leaves have activity as a cytotoxic, anti-diarhhea, etc. Brucea javanica leaves extract was administered orally for first 24 hours at various dose levels (562.5mg/kg bw, 1125 mg/kg bw, 2250 mg/kg bw, and 4500 mg/kg bw) to determine the toxicity effects. The treatment groups were compared to the normal control. Vital organs (liver, heart, lymph, lungs, etc) and body weight were analyzed to study the toxicity. LD50 determined using Reed and Munich formula. Vital organs average weight showed no difference between control group and treatment groups from the lowest dose until the highest dose. In addition, the body weight data showed no difference between control group and treatment groups. LD50 for Brucea javanica extract using Reed and Munich formula was 1003.65 mg/kg bw. The result of the study showed that extract were categorized as lightly toxic.Keywords: Acute toxicity, Brucea javanica Merril, DDY-Mice, LD50</dc:description>
	<dc:publisher xml:lang="en">Journal of Tropical Life Science</dc:publisher>
	<dc:date>2012-09-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/37</dc:identifier>
	<dc:source xml:lang="en">Journal of Tropical Life Science; Vol. 2 No. 2 (2012); 29 - 31</dc:source>
	<dc:source>2527-4376</dc:source>
	<dc:source>2087-5517</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/37/59</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2012 Journal of Tropical Life Science</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by-nc/4.0</dc:rights>
</oai_dc:dc>