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Apigenin, an Anticancer Isolated from Macaranga gigantifolia Leaves

Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences · Vol. 6 No. 1 (2016) · pp. 7–9

DOI
10.11594/jtls.06.01.02
ISSN
2527-4376, 2087-5517
Published
2016-03-04
Publisher
Journal of Tropical Life Science
Language
eng

Abstract

Apigenin, a flavonoid compound has been isolated from the ethyl acetate fraction of methanol extract of Macaranga gigantifolia leaves. Isolation and purification of apigenin conducted using chromatographic method, and chemical structure characterized based on spectroscopic data. In vitro anticancer activity test against murine leukemia P-388 cell line showed potential activity with IC50 14.13 μg/mL.Key words: apigenin, flavones, Macaranga gigantifolia, anticancer, murine leukemia P-388 cell line.

Collaboration network of the authors

40 authors · 199 co-authorship links · showing the 40 most connected

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  • University of Brawijaya
  • National Research and Innovation Agency
  • Jenderal Soedirman University
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Unang SupratmanAffiliation unknown12
Tri MayantiAffiliation unknown7
Al Arofatus NainiAffiliation unknown7
Kindi FarabiAffiliation unknown6
Yoshihito ShionoAffiliation unknown6
Nurlelasari NurlelasariAffiliation unknown6
Desi HarnetiAffiliation unknown5
Ace Tatang HidayatAffiliation unknown5
Erina HilmayantiAffiliation unknown4
Dewa Gede KatjaAffiliation unknown4
Mohamad Nurul AzmiAffiliation unknown4
Gian PrimahanaAffiliation unknown4
Tjandrawati MozefAffiliation unknown3
Ricson Pemimpin HutagaolAffiliation unknown3
Rani MaharaniAffiliation unknown3
Marissa AngelinaAffiliation unknown2
Sofna Dewita Sari BanjarnahorAffiliation unknown2
Darwati DarwatiAffiliation unknown2
Harizon HarizonAffiliation unknown2
Ferry Ferdiansyah SofianAffiliation unknown2
Sri HandayaniUniversity of Brawijaya2
Suyoto SuyotoNational Research and Innovation Agency1
Asha AlfandiAffiliation unknown1
Totok HaryantoAffiliation unknown1
Syahara Nur IslamiAffiliation unknown1
Edy MeiyantoAffiliation unknown1
Ratna Asmah SusidartiAffiliation unknown1
Puspa Dewi Narrij LotulungAffiliation unknown1
Riris Istighfari JenieAffiliation unknown1
Puji LestariJenderal Soedirman University1
Eka Prasasti Nur RachmaniAffiliation unknown1
RehanaAffiliation unknown1
Wahyu SafriansyahAffiliation unknown1
Hadi KuncoroAffiliation unknown1
Indah D. DewijantiAffiliation unknown1
Megawati MegawatiAffiliation unknown1
Indah Dwiatmi DewijantiAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://jtrolis.ub.ac.id/index.php/jtrolis/oai, first harvested 9 Nov 2026, last seen 9 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">Apigenin, an Anticancer Isolated from Macaranga gigantifolia Leaves</dc:title>
	<dc:creator xml:lang="en">Fajriah, Sofa</dc:creator>
	<dc:creator xml:lang="en">Megawati, Megawati</dc:creator>
	<dc:creator xml:lang="en">Darmawan, Akhmad</dc:creator>
	<dc:description xml:lang="en">Apigenin, a flavonoid compound has been isolated from the ethyl acetate fraction of methanol extract of Macaranga gigantifolia leaves. Isolation and purification of apigenin conducted using chromatographic method, and chemical structure characterized based on spectroscopic data. In vitro anticancer activity test against murine leukemia P-388 cell line showed potential activity with IC50 14.13 μg/mL.Key words: apigenin, flavones, Macaranga gigantifolia, anticancer, murine leukemia P-388 cell line.</dc:description>
	<dc:publisher xml:lang="en">Journal of Tropical Life Science</dc:publisher>
	<dc:date>2016-03-04</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/300</dc:identifier>
	<dc:identifier>10.11594/jtls.06.01.02</dc:identifier>
	<dc:source xml:lang="en">Journal of Tropical Life Science; Vol. 6 No. 1 (2016); 7-9</dc:source>
	<dc:source>2527-4376</dc:source>
	<dc:source>2087-5517</dc:source>
	<dc:source>10.11594/jtls.6.1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/300/pdf</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2016 Journal of Tropical Life Science</dc:rights>
</oai_dc:dc>