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Immunomodulatory Activity of Methanol Leaf Extract of Neem (Azadirachta indica Juss) Against Suppressor and Proinflammatory Molecules

Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences · Vol. 11 No. 3 (2021) · pp. 309–315

DOI
10.11594/jtls.11.03.07
ISSN
2527-4376, 2087-5517
Published
2021-09-30
Publisher
Journal of Tropical Life Science
Language
eng
License
creativecommons.org/licenses/by-nc/4.0

Abstract

Neem plant is rich in bioactive constituents, which make it massively discussed the treatment of various diseases. A study on the immunomodulatory activities of neem is given here. This current work aimed to investigate the effects of neem leaf extract on immunocompetent cells. In vivo experiment was carried out using mice (Mus musculus) Â induced with DMBA, comprising positive control, negative control, and treatments of neem leaf extracts (250, 500, and 1000 ppm). Data obtained from flow cytometric analysis were evaluated using BD Cellquest ProTM software, then statistically analyzed in SPSS version 21. Parametric analysis in one-way ANOVA was performed at a significance level of 5%. The significant difference was compared in the Duncan test. The results showed that administration of neem leaf extracts significantly affected the expression of CD4+, CD8+, CD25+, CD62L, IL-10, and IL-17 cells.Neem leaf extract has immunomodulatory activities by increasing pressure molecules and decreasing pro-inflammatory molecules

Keywords

Collaboration network of the authors

40 authors · 121 co-authorship links · 2 across different organisations · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • University of Brawijaya
  • Hasanuddin University
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Sri RahayuHasanuddin University5
Nashi WidodoUniversity of Brawijaya4
Aris SoewondoAffiliation unknown4
Lisdiana LisdianaAffiliation unknown3
Sri WidyartiAffiliation unknown3
Fikriya Novita SariAffiliation unknown3
Yoga Dwi JatmikoAffiliation unknown3
Moh DliyauddinAffiliation unknown2
Hideo TsuboiAffiliation unknown2
Ana FatonahAffiliation unknown2
Muhammad Halim NatsirUniversity of Brawijaya2
Mansur IbrahimAffiliation unknown2
Farida RachmawatiAffiliation unknown2
Sefihara Paramitha SaktiAffiliation unknown2
Dwi purno WidekdoAffiliation unknown2
Wayan Firdaus MahmudyUniversity of Brawijaya1
Achmad RidokUniversity of Brawijaya1
Supanto SupantoAffiliation unknown1
Hartiwiningsih HartiwiningsihAffiliation unknown1
Nurkolis NurkolisAffiliation unknown1
Artadhewi Adhi WijayaAffiliation unknown1
Mohammad Setya AsihAffiliation unknown1
Yovitha YuliejantiningsihAffiliation unknown1
Titik HaryatiAffiliation unknown1
Sofia Nur CahyaniAffiliation unknown1
Belinda Nabiila Al FaizahAffiliation unknown1
Rif'atul Hawani. BAffiliation unknown1
Nabila Shafa Yumna SalsabilaAffiliation unknown1
Noviana Dwi LestariAffiliation unknown1
Agung Pramana Warih MahendraAffiliation unknown1
Adhitya Rol AsmiAffiliation unknown1
Bintang Hidir AliAffiliation unknown1
Rama Agas HidayatAffiliation unknown1
Iqbal FajriAffiliation unknown1
Syarifuddin SyarifuddinAffiliation unknown1
Titiek Indhira AgustinAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://jtrolis.ub.ac.id/index.php/jtrolis/oai, first harvested 9 Nov 2026, last seen 9 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">Immunomodulatory Activity of Methanol Leaf Extract of Neem (Azadirachta indica Juss) Against Suppressor and Proinflammatory Molecules</dc:title>
	<dc:creator xml:lang="en">Supriyanto, Supriyanto</dc:creator>
	<dc:creator xml:lang="en">Widjanarko, Simon Bambang</dc:creator>
	<dc:creator xml:lang="en">Rifa'i, Muhaimin</dc:creator>
	<dc:creator xml:lang="en">Yunianta, Yunianta</dc:creator>
	<dc:subject xml:lang="en">Neem</dc:subject>
	<dc:subject xml:lang="en">immunocompetent cells</dc:subject>
	<dc:subject xml:lang="en">cytokine</dc:subject>
	<dc:subject xml:lang="en">immunomodulator</dc:subject>
	<dc:description xml:lang="en">Neem plant is rich in bioactive constituents, which make it massively discussed the treatment of various diseases. A study on the immunomodulatory activities of neem is given here. This current work aimed to investigate the effects of neem leaf extract on immunocompetent cells. In vivo experiment was carried out using mice (Mus musculus)  induced with DMBA, comprising positive control, negative control, and treatments of neem leaf extracts (250, 500, and 1000 ppm). Data obtained from flow cytometric analysis were evaluated using BD Cellquest ProTM software, then statistically analyzed in SPSS version 21. Parametric analysis in one-way ANOVA was performed at a significance level of 5%. The significant difference was compared in the Duncan test. The results showed that administration of neem leaf extracts significantly affected the expression of CD4+, CD8+, CD25+, CD62L, IL-10, and IL-17 cells .Neem leaf extract has immunomodulatory activities by increasing pressure molecules and decreasing pro-inflammatory molecules</dc:description>
	<dc:publisher xml:lang="en">Journal of Tropical Life Science</dc:publisher>
	<dc:date>2021-09-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/1780</dc:identifier>
	<dc:identifier>10.11594/jtls.11.03.07</dc:identifier>
	<dc:source xml:lang="en">Journal of Tropical Life Science; Vol. 11 No. 3 (2021); 309 - 315</dc:source>
	<dc:source>2527-4376</dc:source>
	<dc:source>2087-5517</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/1780/pdf</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2021 Journal of Tropical Life Science</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by-nc/4.0</dc:rights>
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