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Correlation between Neutrophil/Lymphocyte Ratio (NLR), lipid profile, lesion location and vascular cognitive impairment in acute ischemic stroke patients

Jurnal Keperawatan Padjadjaran · Vol. 12 No. 2 (2024) · pp. 144–152

DOI
10.24198/jkp.v12i2.2526
ISSN
2442-7276, 2338-5324
Published
2024-08-23
Publisher
Faculty of Nursing Universitas Padjadjaran
Language
eng
License
creativecommons.org/licenses/by-sa/4.0/

Abstract

Background: Stroke is the leading cause of long-term disability with significant clinical and socioeconomic impact worldwide. Hyperlipidemia and inflammation play major roles in ischemic stroke. This research focuses on the correlation of three factors, namely Neutrophil-Lymphocyte Ratio (NLR), lipid profile, and lesion location, with Vascular Cognitive Impairment (VCI). These factors may serve as potential predictors for VCI. Purpose: This research aims to study the correlation between NLR, lipid profile, and lesion location with vascular cognitive impairment. Besides, this research aims to explore those potential biomarkers as predictors of vascular cognitive impairment. Methods: This was a cross-sectional study which included 107 patients diagnosed with ischemic stroke from February 2022 to January 2023 with a history of admission to the hospital within 72 hours. After signed an informed consent form, every patient had history taking, physical exam, lipid profile, routine blood test, Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment Indonesian Version (MoCA-Ina) on the first hospital day. Statistical tests were done with Spearman correlation method. Results: The data distribution was not normal for INR and MoCA-INA values (p<0.05). Total cholesterol was insignificantly (p=0.092) correlated with MoCA-INA score with low correlation value (r=-0.293). HDL was significantly (p=0.035) correlated with MoCA-INA score with moderate correlation value (r=0.461). LDL was significantly (p=0.028) correlated with MoCA-INA score with low correlation value (r=-0.387). Triglycerides was insignificantly (p=0.440) correlated with MoCA-INA score with very weak correlation value (r=-0.137). NLR was significantly (p=0.015) correlated with MoCA-INA score with moderate correlation value (r=-0.412). Conclusions: Lipid profile is correlated with cognitive impairment in post stroke patients, with HDL being a protective factor, and LDL as risk factor. NLR was associated with worse cognitive function and LDL was directly proportional to NLR. Lesion location reporting was highly heterogeneous and more uniformed reporting is recommended for future research.

Keywords

Collaboration network of the authors

40 authors · 179 co-authorship links · showing the 40 most connected

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  • Universitas Gadjah Mada
  • Universitas 'Aisyiyah Yogyakarta
  • Affiliation unknown
  • Different organisations
  • Same organisation
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  • Thicker line = more joint articles · bigger circle = more articles
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Co-authorOrganisationJoint articles
Daru LestantyoAffiliation unknown2
Anit Pranita DeviAffiliation unknown1
Umi Budi RahayuAffiliation unknown1
Wanda Kurnia YudaAffiliation unknown1
Poppy Elisano ArfandaAffiliation unknown1
Arif BulqiniAffiliation unknown1
Puspodari PuspodariAffiliation unknown1
Toho Cholik MutohirAffiliation unknown1
Yusuf PerdanaAffiliation unknown1
Rinaldo Adi PratamaAffiliation unknown1
Sumargono SumargonoAffiliation unknown1
Ika YatmikasariAffiliation unknown1
Yunita SariUniversitas Gadjah Mada1
Tina AfiatinAffiliation unknown1
H.W. SetiawanAffiliation unknown1
Muchtaruddin MansyurAffiliation unknown1
Lugyanti SukrismanAffiliation unknown1
Al RasyidAffiliation unknown1
Jusuf MisbachAffiliation unknown1
Jan S PurbaAffiliation unknown1
Ina S TimanAffiliation unknown1
Efta YudiarsahAffiliation unknown1
Etika Ratna NoerAffiliation unknown1
Kurnia Mar’atus SolichahUniversitas 'Aisyiyah Yogyakarta1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://jkp.fkep.unpad.ac.id/index.php/jkp/oai, first harvested 9 Nov 2026, last seen 9 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Correlation between Neutrophil/Lymphocyte Ratio (NLR), lipid profile, lesion location and vascular cognitive impairment in acute ischemic stroke patients</dc:title>
	<dc:creator>Ristinawati, Ira</dc:creator>
	<dc:creator>Tan, Kenneth</dc:creator>
	<dc:creator>Benedictus, Benedictus</dc:creator>
	<dc:creator>Hafizhan, Muhammad</dc:creator>
	<dc:creator>Putra, Stefanus Erdana</dc:creator>
	<dc:creator>Suroto, Suroto</dc:creator>
	<dc:creator>Mirawati, Diah Kurnia</dc:creator>
	<dc:creator>Subandi, Subandi</dc:creator>
	<dc:creator>Danuaji, Rivan</dc:creator>
	<dc:creator>Budianto, Pepi</dc:creator>
	<dc:creator>Hambarsari, Yetty</dc:creator>
	<dc:creator>Hamidi, Baarid Luqman</dc:creator>
	<dc:creator>Prabaningtyas, Hanindia Riani</dc:creator>
	<dc:creator>Hutabarat, Ervina Arta Jayanti</dc:creator>
	<dc:creator>Tejomukti, Teddy</dc:creator>
	<dc:creator>Tedjo, Raden Andi Ario</dc:creator>
	<dc:subject xml:lang="en-US">cognitive</dc:subject>
	<dc:subject xml:lang="en-US">HDL</dc:subject>
	<dc:subject xml:lang="en-US">LDL</dc:subject>
	<dc:subject xml:lang="en-US">location</dc:subject>
	<dc:subject xml:lang="en-US">NLR</dc:subject>
	<dc:subject xml:lang="en-US">stroke</dc:subject>
	<dc:description xml:lang="en-US">Background: Stroke is the leading cause of long-term disability with significant clinical and socioeconomic impact worldwide. Hyperlipidemia and inflammation play major roles in ischemic stroke. This research focuses on the correlation of three factors, namely Neutrophil-Lymphocyte Ratio (NLR), lipid profile, and lesion location, with Vascular Cognitive Impairment (VCI). These factors may serve as potential predictors for VCI.
Purpose: This research aims to study the correlation between NLR, lipid profile, and lesion location with vascular cognitive impairment. Besides, this research aims to explore those potential biomarkers as predictors of vascular cognitive impairment.
Methods: This was a cross-sectional study which included 107 patients diagnosed with ischemic stroke from February 2022 to January 2023 with a history of admission to the hospital within 72 hours. After signed an informed consent form, every patient had history taking, physical exam, lipid profile, routine blood test, Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment Indonesian Version (MoCA-Ina) on the first hospital day. Statistical tests were done with Spearman correlation method.
Results: The data distribution was not normal for INR and MoCA-INA values (p&amp;lt;0.05).  Total cholesterol was insignificantly (p=0.092) correlated with MoCA-INA score with low correlation value (r=-0.293). HDL was significantly (p=0.035) correlated with MoCA-INA score with moderate correlation value (r=0.461). LDL was significantly (p=0.028) correlated with MoCA-INA score with low correlation value (r=-0.387). Triglycerides was insignificantly (p=0.440) correlated with MoCA-INA score with very weak correlation value (r=-0.137). NLR was significantly (p=0.015) correlated with MoCA-INA score with moderate correlation value (r=-0.412).
Conclusions: Lipid profile is correlated with cognitive impairment in post stroke patients, with HDL being a protective factor, and LDL as risk factor. NLR was associated with worse cognitive function and LDL was directly proportional to NLR. Lesion location reporting was highly heterogeneous and more uniformed reporting is recommended for future research.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Nursing Universitas Padjadjaran</dc:publisher>
	<dc:date>2024-08-23</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jkp.fkep.unpad.ac.id/index.php/jkp/article/view/2526</dc:identifier>
	<dc:identifier>10.24198/jkp.v12i2.2526</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Keperawatan Padjadjaran; Vol. 12 No. 2 (2024): Jurnal Keperawatan Padjadjaran; 144-152</dc:source>
	<dc:source>2442-7276</dc:source>
	<dc:source>2338-5324</dc:source>
	<dc:source>10.24198/jkp.v12i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jkp.fkep.unpad.ac.id/index.php/jkp/article/view/2526/396</dc:relation>
	<dc:relation>10.24198/jkp.v9i1.1446.s771</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 Ira Ristinawati, Kenneth Tan, Benedictus Benedictus, Muhammad Hafizhan, Stefanus Erdana Putra, Suroto Suroto, Diah Kurnia Mirawati, Subandi Subandi, Rivan Danuaji, Pepi Budianto, Yetty Hambarsari, Baarid Luqman Hamidi, Hanindia Riani Prabaningtyas, Ervina Arta Jayanti Hutabarat, Teddy Tejomukti, Raden Andi Ario Tedjo</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-sa/4.0/</dc:rights>
</oai_dc:dc>