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Efficacy of Sauropus androgynous Leaves Extract Gel on Burn Wound Healing in Albino Rats

Jurnal Medik Veteriner · Vol. 6 No. 3 (2023) · pp. 107–115

DOI
10.20473/jmv.vol6.iss3.2023.107-115
ISSN
2581-012X, 2615-7497
Published
2023-12-31
Publisher
Universitas Airlangga
Language
eng
License
creativecommons.org/licenses/by-nc-sa/4.0

Abstract

Burns not only damage skin locally but generally affect the body system and have been related as the secondary cause of death. Burns can be effectively treated with a topical drug to prevent chronic inflammation. Burn wound healing is really important for ensuring overall health and well-being. This study aimed to determine the effect of Sauropus androgynous leaves extract gel on the number of fibroblasts, fibrocytes, and collagen density on burn wound healing in albino rats. A total of 50 male albino rats were randomly divided into five groups i.e. (C-) was normal skin, (C+) was skin burn treated with placebo, (T1) was skin burn treated with 2.5% of S. androgynous leaves extract gel, (T2) was skin burn treated with 5% of S. androgynous leaves extract gel, and (T3) was skin burn treated with 10% of S. androgynous leaves extract the gel. The amount of 25 albino rats' skin samples were collected on the 8th day, and the remaining samples were collected on the 15th day. The results showed that 10% of S. androgynous leaves extract gel improved faster, as indicated by the increased number of fibroblasts, fibrocytes, and collagen density. This study can be concluded that 10% of S. androgynous leaves extract gel was the effective dosage to increase the number of fibroblasts, fibrocytes, and collagen density in burn wound healing.

Keywords

Collaboration network of the authors

40 authors · 225 co-authorship links · showing the 40 most connected

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  • Universitas Syiah Kuala
  • Affiliation unknown
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Co-authorOrganisationJoint articles
Nusdianto TriakosoAffiliation unknown6
Bambang Sektiari LukiswantoAffiliation unknown5
Amung Logam SaputroAffiliation unknown4
Mustofa Helmi EffendiAffiliation unknown4
Ikechukwu Benjamin MosesAffiliation unknown4
Lucia Tri SuwantiAffiliation unknown4
Wiwik Misaco YuniartiAffiliation unknown4
Mirza Atikah Madarina HisyamAffiliation unknown4
Maya Nurwartanti YunitaAffiliation unknown3
Prima Ayu WibawatiAffiliation unknown3
Boedi SetiawanAffiliation unknown3
Sheila Marty YanestriaAffiliation unknown3
Siti Rani AyutiUniversitas Syiah Kuala3
Riza Zainuddin AhmadAffiliation unknown3
Jola RahmahaniAffiliation unknown3
Poedji HastutiekAffiliation unknown3
Mirni LamidAffiliation unknown3
Iwan Sahrial HamidAffiliation unknown2
Hardany PrimarizkyAffiliation unknown2
Yulianna PuspitasariAffiliation unknown2
Mariana Febrilianti Resilinda PutriAffiliation unknown2
Freshinta Jellia WibisonoAffiliation unknown2
Abdullah HasibAffiliation unknown2
Ima FauziahAffiliation unknown2
Muhammad Khaliim Jati KusalaAffiliation unknown2
Lina SusantiAffiliation unknown2
Suhita AryalokaAffiliation unknown2
Suryo KuncorojaktiAffiliation unknown2
Diyantoro DiyantoroAffiliation unknown2
Widya Paramita LokapirnasariAffiliation unknown2
Nenny HarijaniAffiliation unknown2
Hani PlumeriastutiAffiliation unknown2
Fedik Abdul RantamAffiliation unknown2

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/JMV/oai, first harvested 9 Nov 2026, last seen 9 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Efficacy of Sauropus androgynous Leaves Extract Gel on Burn Wound Healing in Albino Rats</dc:title>
	<dc:creator> Panggabean, Rosenna Tiara</dc:creator>
	<dc:creator>Sudjarwo, Sri Agus </dc:creator>
	<dc:creator>Ma'ruf, Anwar</dc:creator>
	<dc:creator>Widiyatno, Thomas Valentinus</dc:creator>
	<dc:creator>Yudaniayanti, Ira Sari </dc:creator>
	<dc:creator>Kurnijasanti, Rochmah </dc:creator>
	<dc:creator>Khairullah, Aswin Rafif</dc:creator>
	<dc:subject xml:lang="en-US">collagen</dc:subject>
	<dc:subject xml:lang="en-US">fibroblast</dc:subject>
	<dc:subject xml:lang="en-US">fibrocyte</dc:subject>
	<dc:subject xml:lang="en-US">health</dc:subject>
	<dc:subject xml:lang="en-US">Sauropus androgynous</dc:subject>
	<dc:description xml:lang="en-US">Burns not only damage skin locally but generally affect the body system and have been related as the secondary cause of death. Burns can be effectively treated with a topical drug to prevent chronic inflammation. Burn wound healing is really important for ensuring overall health and well-being. This study aimed to determine the effect of Sauropus androgynous leaves extract gel on the number of fibroblasts, fibrocytes, and collagen density on burn wound healing in albino rats. A total of 50 male albino rats were randomly divided into five groups i.e. (C-) was normal skin, (C+) was skin burn treated with placebo, (T1) was skin burn treated with 2.5% of S. androgynous leaves extract gel, (T2) was skin burn treated with 5% of S. androgynous leaves extract gel, and (T3) was skin burn treated with 10% of S. androgynous leaves extract the gel. The amount of 25 albino rats' skin samples were collected on the 8th day, and the remaining samples were collected on the 15th day. The results showed that 10% of S. androgynous leaves extract gel improved faster, as indicated by the increased number of fibroblasts, fibrocytes, and collagen density. This study can be concluded that 10% of S. androgynous leaves extract gel was the effective dosage to increase the number of fibroblasts, fibrocytes, and collagen density in burn wound healing.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Airlangga</dc:publisher>
	<dc:date>2023-12-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/JMV/article/view/46258</dc:identifier>
	<dc:identifier>10.20473/jmv.vol6.iss3.2023.107-115</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Medik Veteriner; Vol. 6 No. 3 (2023): Special Issue: International Conference on Veterinary Medicine and Health Sciences (ICVMHS); 107-115</dc:source>
	<dc:source>2581-012X</dc:source>
	<dc:source>2615-7497</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/JMV/article/view/46258/27580</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Rosenna Tiara Panggabean, Sri Agus Sudjarwo, Anwar Ma'ruf, Thomas Valentinus Widiyatno, Ira Sari Yudaniayanti, Rochmah Kurnijasanti, Aswin Rafif Khairullah</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
</oai_dc:dc>